MLLT1 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1)
1997-12-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
DNA/RNA
Transcription
4.7 kb mRNA; coding sequence: 1.7 kb
Proteins
Description
559 amino acids; 62 kDa; serine/proline rich protein; contains
a nuclear targeting sequence and a consensus sequence for ATP/GTP binding
Expression
wide
Localisation
nuclear
Function
transcription activator
Homology
with AF9
Implicated in
Entity name
Disease
ALL (CD19+), biphenotypic AL, AML (M4/M5); mainly congenital;
treatment related leukaemia
Prognosis
very poor, except in rare T-cell cases
Cytogenetics
detected with G banding
Hybrid gene
5 MLL - 3 ENL
Fusion protein
AT hook and DNA methyltransferase from MLL fused to, most often,
the nearly entire ENL
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7542910 | 1995 | Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. | Bernard OA et al |
| 8934541 | 1996 | Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation. | Joh T et al |
| 8558942 | 1996 | 11q23 rearrangements in acute leukemia. | Rubnitz JE et al |
| 1423624 | 1992 | Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. | Tkachuk DC et al |
| 8977038 | 1996 | Chromosome abnormalities in leukaemia: the 11q23 paradigm. | Young BD et al |
Other Information
Locus ID:
NCBI: 4298
MIM: 159556
HGNC: 7134
Ensembl: ENSG00000130382
Variants:
dbSNP: 4298
ClinVar: 4298
TCGA: ENSG00000130382
COSMIC: MLLT1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000130382 | ENST00000252674 | Q03111 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36435883 | 2023 | The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia. | 4 |
| 36735043 | 2023 | Circvrk1 downregulation attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through modulating the miR-150-5p/MLLT1 axis. | 0 |
| 36435883 | 2023 | The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia. | 4 |
| 36735043 | 2023 | Circvrk1 downregulation attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through modulating the miR-150-5p/MLLT1 axis. | 0 |
| 34174329 | 2022 | The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) - Multimodal Transcriptional Switches With Roles in Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer. | 11 |
| 34853079 | 2022 | KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs. | 25 |
| 34174329 | 2022 | The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) - Multimodal Transcriptional Switches With Roles in Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer. | 11 |
| 34853079 | 2022 | KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs. | 25 |
| 33749253 | 2021 | Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants. | 3 |
| 33749253 | 2021 | Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants. | 3 |
| 31405949 | 2019 | The efficiency of murine MLL-ENL-driven leukemia initiation changes with age and peaks during neonatal development. | 15 |
| 31405949 | 2019 | The efficiency of murine MLL-ENL-driven leukemia initiation changes with age and peaks during neonatal development. | 15 |
| 30066088 | 2018 | ENL: structure, function, and roles in hematopoiesis and acute myeloid leukemia. | 9 |
| 30066088 | 2018 | ENL: structure, function, and roles in hematopoiesis and acute myeloid leukemia. | 9 |
| 28241141 | 2017 | ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia. | 123 |
Citation
Jean-Loup Huret
MLLT1 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1)
Atlas Genet Cytogenet Oncol Haematol. 1997-12-01
Online version: http://atlasgeneticsoncology.org/gene/9/haematological-explorer/teaching-explorer/tumors-explorer/new-content/
