RHOH (Ras homolog gene family, member H)
1998-02-01 Sylvie Galiègue-Zouitina AffiliationU.124 INSERM, I.R.C.L., Place de Verdun, 59045 LILLE Cedex, France
Identity
HGNC
LOCATION
4p14
IMAGE
LEGEND
RHPH (4p13) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
ALIAS
ARHH,TTF
FUSION GENES
DNA/RNA
Description
spans on a 35 kb genomic fragment; two exons separated by a
large intron; small GTPase encoding gene
Transcription
2.2 kb mRNA; coding sequence: 575 bp, located in the second exon
Proteins
Description
191 amino acids; 21 kDa; contains a GTP binding motif, a GTPase
activity site, and a membrane localisation signal (CAAX box) in the very
C-term
Expression
restricted to the hemopoietic tissues
Localisation
plasmic membrane
Function
small GTPase of the Rho subfamily; involved in signal transduction
and cytoskeletal reorganization
Homology
with all GTPases of the Ras superfamily
Implicated in
Disease
follicular NHL
Cytogenetics
observed as a secondary anomaly
Hybrid gene
5 RHOH - 3 BCL6 and 5 BCL6 - 3 RHOH, leading to two fusion
transcripts
Fusion protein
no fusion protein, but promoter exchange between both partner genes
Entity name
t(4;14)(p13;q32)/multiple myeloma --> RHOH - ??
Disease
multiple myeloma
Prognosis
still unknown: only 1 available case
Cytogenetics
observed as a unique anomaly
Hybrid gene
not yet known (under study)
Breakpoints
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7784061 | 1995 | TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation. | Dallery E et al |
| 9226377 | 1997 | Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization. | Dallery-Prudhomme E et al |
Other Information
Locus ID:
NCBI: 399
MIM: 602037
HGNC: 686
Ensembl: ENSG00000168421
Variants:
dbSNP: 399
ClinVar: 399
TCGA: ENSG00000168421
COSMIC: RHOH
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32959187 | 2021 | Weighted gene co-expression network analysis identifies RHOH and TRAF1 as key candidate genes for psoriatic arthritis. | 2 |
| 32959187 | 2021 | Weighted gene co-expression network analysis identifies RHOH and TRAF1 as key candidate genes for psoriatic arthritis. | 2 |
| 31204928 | 2019 | [Expression Difference of RhoH Gene in Leukemia and Its Clinical Significance]. | 1 |
| 31204928 | 2019 | [Expression Difference of RhoH Gene in Leukemia and Its Clinical Significance]. | 1 |
| 27574848 | 2018 | RhoH participates in a multi-protein complex with the zinc finger protein kaiso that regulates both cytoskeletal structures and chemokine-induced T cells. | 8 |
| 29510700 | 2018 | An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration. | 0 |
| 27574848 | 2018 | RhoH participates in a multi-protein complex with the zinc finger protein kaiso that regulates both cytoskeletal structures and chemokine-induced T cells. | 8 |
| 29510700 | 2018 | An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration. | 0 |
| 27740624 | 2016 | RhoH is a negative regulator of eosinophilopoiesis. | 11 |
| 27740624 | 2016 | RhoH is a negative regulator of eosinophilopoiesis. | 11 |
| 23499578 | 2013 | Differential requirement for RhoH in development of TCRαβ CD8αα IELs and other types of T cells. | 9 |
| 23850828 | 2013 | Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders. | 37 |
| 23499578 | 2013 | Differential requirement for RhoH in development of TCRαβ CD8αα IELs and other types of T cells. | 9 |
| 23850828 | 2013 | Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders. | 37 |
| 22474251 | 2012 | RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans. | 22 |
Citation
Sylvie Galiègue-Zouitina
RHOH (Ras homolog gene family, member H)
Atlas Genet Cytogenet Oncol Haematol. 1998-02-01
Online version: http://atlasgeneticsoncology.org/gene/93
