POU2AF1 (POU domain, class 2, associating factor 1)
1998-03-01 Sylvie Galiègue-Zouitina AffiliationU.124 INSERM, I.R.C.L., Place de Verdun, 59045 LILLE Cedex, France
Identity
HGNC
LOCATION
11q23.1
IMAGE
LEGEND
POU2AF1 (11q23) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
ALIAS
BOB1,OBF-1,OBF1,OCAB
FUSION GENES
DNA/RNA
DNA Diagram
Description
spans on a 30 kb genomic fragment; five exons; large fifth
exon, with many 3 -UTR repetitive elements, two pyrimidine rich regions (a
duplicated CT- rich region and a [CCTT]n tetranucleotide tandem repeat) and
a 282 nucleotides long Alu element
Transcription
3.4 kb mRNA; coding sequence: 770 bp, spanning from the end
of exon 1 to the beginning of exon 5
Proteins
Description
256 amino acids; 27.4 kDa; proline rich protein with no
recognizable domain or motifs
Expression
constitutively expressed in B-cells and inducible in T-cells
Localisation
nuclear
Function
B-cell specific transcriptional coactivator: involved in the transcription of immunoglobulin genes through recruitment to the highly conserved octamer site of immunoglobulin promoters, mediated by either Oct-1 or Oct-2 transcription factor; forms a ternary complex on DNA together with either Oct-1 or Oct-2 transcription factor; is essential for the response of B-cells to antigens and is required for the formation of germinal centres no homology to known proteins.
Implicated in
Disease
NHL
Cytogenetics
found in complex caryotypes
Hybrid gene
5 BOB1- 3 BCL6 and 5 BCL6 - 3BOB1, leading to two fusion
transcripts
Fusion protein
no fusion protein, but promoter exchange between both partner genes
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7779176 | 1995 | A B-cell coactivator of octamer-binding transcription factors. | Gstaiger M et al |
| 7623806 | 1995 | Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. | Luo Y et al |
| 8849727 | 1996 | B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. | Schubart DB et al |
| 7859290 | 1995 | OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. | Strubin M et al |
| 8751468 | 1996 | Heterogeneity of breakpoints at the transcriptional co-activator gene, BOB-1, in lymphoproliferative disease. | Yuille MA et al |
| 9211847 | 1997 | Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. | Zwilling S et al |
Other Information
Locus ID:
NCBI: 5450
MIM: 601206
HGNC: 9211
Ensembl: ENSG00000110777
Variants:
dbSNP: 5450
ClinVar: 5450
TCGA: ENSG00000110777
COSMIC: POU2AF1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000110777 | ENST00000393067 | Q16633 |
| ENSG00000110777 | ENST00000531398 | E9PKH4 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38254723 | 2024 | Transcriptional Coactivator BOB1 (OBF1, OCA-B) Modulates the Specificity of DNA Recognition by the POU-Domain Factors OCT1 and OCT2 in a Monomeric Configuration. | 0 |
| 38254723 | 2024 | Transcriptional Coactivator BOB1 (OBF1, OCA-B) Modulates the Specificity of DNA Recognition by the POU-Domain Factors OCT1 and OCT2 in a Monomeric Configuration. | 0 |
| 36480042 | 2023 | Four Genes Predictive for the Severity of Hematological Damage Reveal a Similar Response after X Irradiation and Chemotherapy. | 0 |
| 36480042 | 2023 | Four Genes Predictive for the Severity of Hematological Damage Reveal a Similar Response after X Irradiation and Chemotherapy. | 0 |
| 33512466 | 2021 | OBF1 and Oct factors control the germinal center transcriptional program. | 11 |
| 33949290 | 2021 | POU2AF1 promotes MSCs adipogenesis by inhibiting HDAC1 expression. | 3 |
| 34623901 | 2021 | Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci. | 10 |
| 33512466 | 2021 | OBF1 and Oct factors control the germinal center transcriptional program. | 11 |
| 33949290 | 2021 | POU2AF1 promotes MSCs adipogenesis by inhibiting HDAC1 expression. | 3 |
| 34623901 | 2021 | Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci. | 10 |
| 30681271 | 2019 | Evaluation of SUMO1 and POU2AF1 in whole blood from rheumatoid arthritis patients and at risk relatives. | 5 |
| 31053401 | 2019 | BOB.1 controls memory B-cell fate in the germinal center reaction. | 5 |
| 30681271 | 2019 | Evaluation of SUMO1 and POU2AF1 in whole blood from rheumatoid arthritis patients and at risk relatives. | 5 |
| 31053401 | 2019 | BOB.1 controls memory B-cell fate in the germinal center reaction. | 5 |
| 29496744 | 2018 | Loss of OcaB Prevents Age-Induced Fat Accretion and Insulin Resistance by Altering B-Lymphocyte Transition and Promoting Energy Expenditure. | 18 |
Citation
Sylvie Galiègue-Zouitina
POU2AF1 (POU domain, class 2, associating factor 1)
Atlas Genet Cytogenet Oncol Haematol. 1998-03-01
Online version: http://atlasgeneticsoncology.org/gene/94/pou2af1-(pou-domain-class-2-associating-factor-1)
