t(10;11)(p12;q21) PICALM/MLLT10
1998-01-01 Jean-Loup Huret , Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
a mainly T-cell ALL; at times AML and/or AML with T-cellcommon progenitor may be involved; FAB: L1/L2
Phenotype stem cell origin
a myelomonocytic/T- cell
Epidemiology
< 1% of ALL; about 5 % of T-ALL; sex ratio: 9M/5F (from 14 cases herein reviewed)
Clinics
organomegaly; no CNS involvement; blood data: high WBC (range 20-170 X 109/l)
Prognosis
median survival: 22 mths in this review; range: 0-33+ mths, n=11(but we are to be cautious: cases ascertained by molecular studies areneeded before true prognostic ascertainment)
Cytogenetics
Cytogenetics molecular
investigations are required
Additional anomalies
most often (11/15 cases) present; del(5q), +8, and +19already recurrent
Genes Involved and Proteins
Gene name
MLLT10 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10)
Location
10p12.31
Dna rna description
5 telomeric --> 3 centromeric orientation
Protein description
contains 3 Zn fingezrs and a leucine zipper; nuclearlocalisation; transcription factor
Gene name
PICALM (clathrin assembly lymphoid myeloid leukemia gene)
Location
11q14.2
Protein description
role in the integration of different signals;
Result of the Chromosomal Anomaly
Transcript
both 5 CALM - 3 AF10 and 5 AF10 - 3 CALM are expressed
Description
1- a 1595 amino acids protein with N-term and most of CALM(except the last 4 amino acids!) fused to most of AF10 from amino acid 81(excluding the N-term zinc finger of AF10) C-term; 2- and a small 84 aminoacids protein with N-term zinc finger from AF10 fused to the very C-termend of CALM
Oncogenesis
it is not known which of the 2 fusion protein has the critical role
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35082269 | 2022 | Clinico-biological features of T-cell acute lymphoblastic leukemia with fusion proteins. | 60 |
| 38151288 | 2024 | Genetic Characterization of Pediatric Mixed Phenotype Acute Leukemia (MPAL). | 60 |
| 36916780 | 2023 | RNA sequencing of myeloid sarcoma, shed light on myeloid sarcoma stratification. | 54 |
| 30914738 | 2019 | Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma. | 51 |
| 33317567 | 2020 | Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability. | 42 |
| 38306602 | 2024 | Structural variants involving MLLT10 fusion are associated with adverse outcomes in pediatric acute myeloid leukemia. | 40 |
| 23831922 | 2013 | The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest. | 39 |
| 38493200 | 2024 | Application of droplet digital PCR in minimal residual disease monitoring of rare fusion transcripts and mutations in haematological malignancies. | 34 |
| 38895061 | 2024 | PICALM::MLLT10 may indicate a new subgroup of acute leukemias with miscellaneous immunophenotype and poor initial treatment response but showing sensitivity to venetoclax. | 18 |
| 33489453 | 2020 | Fatal hyperleukocytic T lymphoblastic lymphoma/leukemia complicated with multi-gene fusion and mutation: clinical revelation and perception. | 16 |
| 36544346 | 2023 | The First Case of Acute Myeloid Leukemia With t(10;11)(p13;q21);PICALM-MLLT10 Rearrangement Presenting With Extensive Skin Involvement. | 11 |
| 38429501 | 2024 | Genomic and global gene expression profiling in pediatric and young adult acute leukemia with PICALM::MLLT10 Fusion. | 0 |
| 37743097 | 2024 | Treatment outcomes of childhood PICALM::MLLT10 acute leukaemias. | 0 |
| 38971327 | 2024 | Clinicopathologic features and outcomes of acute leukemia harboring PICALM::MLLT10 fusion. | 0 |
| 22871473 | 2012 | PICALM-MLLT10 acute myeloid leukemia: a French cohort of 18 patients. | 0 |
| 39499083 | 2024 | PICALM-MLLT10 fusion gene in hematological neoplasms: clinical features, current practices, and prognoses. | 0 |
| 23670296 | 2013 | Detection of PICALM-MLLT10 (CALM-AF10) and outcome in children with T-lineage acute lymphoblastic leukemia. | 0 |
| 20875875 | 2010 | Acute leukemia with PICALM-MLLT10 fusion gene: diagnostic and treatment struggle. | 0 |
| 23673860 | 2013 | New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia. | 0 |
| 39604201 | 2024 | PICALM::MLLT10 fusion gene positive acute myeloid leukemia with PHF6 mutation and presented with CD7 positive immunophenotype. | 0 |
| 37171905 | 2023 | An unusual presentation of a pediatric patient with mixed phenotypic acute leukemia with PICALM::MLLT10 gene rearrangement. | 0 |
| 22235851 | 2012 | EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia. | 0 |
| 37439579 | 2023 | Diagnostic challenge in a case of ambiguous lineage acute leukemia with PICALM::MLLT10 rearrangement. | 0 |
| 31739126 | 2020 | Molecular and phenotypic characterization of an early T-cell precursor acute lymphoblastic lymphoma harboring PICALM-MLLT10 fusion with aberrant expression of B-cell antigens. | 0 |
| 40013393 | 2025 | Ex vivo drug response profiling guides therapy in a case of high-risk acute undifferentiated leukemia with PICALM::MLLT10. | 0 |
| 16518848 | 2006 | Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9. | 0 |
| 30227397 | 2018 | Mediastinal Myeloid Sarcoma with TP53 Mutation Preceding Acute Myeloid Leukemia with a PICALM-MLLT10 Fusion Gene. | 0 |
| 29189509 | 2018 | Successful Treatment of a Very Late Isolated Relapse in an Adolescent With a PICALM-MLLT10 Positive T-lineage Acute Lymphoblastic Leukemia. | 0 |
| 38951073 | 2024 | [PICALM-MLLT10 fusion gene positive with multiple gene mutations in a child with T-lymphoblastic lymphoma/leukemia: a case report]. | 0 |
| 15843827 | 2005 | Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations. | 0 |
Bibliography
No bibliography items were found for this article.
Summary
Fusion gene
PICALM/MLLT10 PICALM (11q14.2) MLLT10 (10p12.31) M t(10;11)(p12;q14) t(10;11)(p12;q23) t(10;19;11)(p12;p13;q14) t(9;11)(p12;q14)|PICALM/MLLT10 PICALM (11q14.2) MLLT10 (10p12.31) TF LAML|PICALM/MLLT10 PICALM (11q14.2) MLLT10 (10p12.31) TIC
Note
the description opf this rare entity is arduous, since cases without molecular studies can be confused with cases of t(10;11)(p12;q23)
t(10;11)(p13;q21) G-banding (top 2) - Courtesy Diane H. Norback, Eric B. Johnson, Sara Morrison-Delap UW Cytogenetic Services; middle row: - Courtesy Catherine Roche-Lestienne. R-banding (bottom 2) and Fish studies with MLL probe showing a signal on the normal 11 and one on the der(10) (right) and with chromosome 11 paint - Courtesy Pascale Cornillet-Lefebvre and Stéphanie Struski.
Citation
Jean-Loup Huret ; Jean-Loup Huret
t(10;11)(p12;q21) PICALM/MLLT10
Atlas Genet Cytogenet Oncol Haematol. 1998-01-01
Online version: http://atlasgeneticsoncology.org/haematological/1067
