t(12;17)(p13;q11-21) in ALL

2006-04-01   David Betts 

1.Department of Oncology, University Childrens Hospital, Steinwiesstr. 75, CH-8032 Zò_rich, Switzerland

Clinics and Pathology

Disease

Acute lymphoblastic leukaemia (ALL)

Note

Identical or similar translocations have been reported rarely in acute myeloid leukemia (AML) and acute mixed lineage leukaemia ( t(12;17)(p13;q11-21) in AML ).

Phenotype stem cell origin

Most reports indicate an early pre-B immunophenotype, frequently characterised by low CD10 and positivity of the myeloid marker CD33.

Epidemiology

Rare; non-random translocation that predominantly occurs in children and young adults. No definable sex bias.

Prognosis

Early reports suggested that prognosis may be poor, but there are currently too few reported cases to define a robust association.

Cytogenetics

Cytogenetics morphological

The chromosome 17q breakpoint has been defined in different reports to be between q11-q21. The chromosome 12 breakpoint has been confirmed to be located in 12p13 telomeric to the ETV6/TEL locus. The translocation occurs as the sole or primary event in approximately 50% of cases

Additional anomalies

No consistent picture and only +21 has been reported in more than one case.

Genes Involved and Proteins

Note
Breakpoint on 12p13 telomeric to TEL. Currently the genes involved on both chromosome 12 and 17 are unidentified.

Bibliography

Pubmed IDLast YearTitleAuthors
15341301992t(12;17)(p13;q21) in early pre-B acute lymphoid leukemia.Krance RA et al
14584461992Translocation (12;17)(p11-12;q11-12): a recurrent primary rearrangement in acute leukemia.Liu HW et al
164905982006A t(12;17)(p13;q12) identifies a distinct TEL rearrangement-negative subtype of precursor-B acute lymphoblastic leukemia.Reid AG et al
118013112002Fluorescence in situ hybridization analysis of the cryptic t(12;21) (p13;q22) in childhood B-lineage acute lymphoblastic leukemia.Yehuda-Gafni O et al

Citation

David Betts

t(12;17)(p13;q11-21) in ALL

Atlas Genet Cytogenet Oncol Haematol. 2006-04-01

Online version: http://atlasgeneticsoncology.org/haematological/1072/t(12;17)(p13;q11-21)-in-all

External Links