t(1;3)(p32;p21) TCTA/TAL1

1998-03-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

T-cell ALL

Genes Involved and Proteins

Gene name
TAL1 (T-cell acute leukemia 1)
Location
1p33
Dna rna description
complex alternate splicing
Protein description
contains a basic Helix-Loop-Helix (DNA binding) domain;cforms heterodimers; transcription factor; role in haematopoietic celldifferentiation , associated protein
Gene name
TCTA (T-cell leukemia translocation-associated gene)
Location
3p21.31
Protein description
contains a hydrophobic domain; may be a membrane

Result of the Chromosomal Anomaly

Description

TCTA and TAL1 are in opposite directionit may be that the promoting regions from TCTA disregulate TAL1expression

Bibliography

Pubmed IDLast YearTitleAuthors
77287591995Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation.Aplan PD et al
14026761992Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia.Aplan PD et al

Summary

Fusion gene

TCTA/TAL1 TCTA (3p21.31) TAL1 (1p33) M t(1;3)(p33;p21)

Citation

Jean-Loup Huret

t(1;3)(p32;p21) TCTA/TAL1

Atlas Genet Cytogenet Oncol Haematol. 1998-03-01

Online version: http://atlasgeneticsoncology.org/haematological/1108/t(1;3)(p32;p21)

External Links