t(1;5)(p32;q31) ?/TAL1
1998-09-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
T cell acute lymphocytic leukaemia (T-ALL)
Clinics
yet poorly known: only 1 case: a young adult male patient with high WBC (common features in T-ALL); bone marrow transplantation; complete remission: 43 mths +
Genes Involved and Proteins
Gene name
TAL1 (T-cell acute leukemia 1)
Location
1p33
Dna rna description
complex alternate splicing
Protein description
contains a basic Helix-Loop-Helix (DNA binding) domain; forms heterodimers; transcription factor; role in haematopoietic cell differentiation
Gene name
yet unknown gene
Location
5q31
Result of the Chromosomal Anomaly
Description
breakpoint on TAL1 was found 10kb upstream the gene, as was found in the cases of t(1;3)(p32;p21), while it is more 3, within the gene, in the t(1;14)(p32;q11) and in TAL1 deletions.
Expression localisation
high nuclear expression
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 20566737 | 2010 | Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells. | 167 |
| 21282467 | 2011 | Role of helix-loop-helix proteins during differentiation of erythroid cells. | 155 |
| 35514954 | 2022 | E Protein Transcription Factors as Suppressors of T Lymphocyte Acute Lymphoblastic Leukemia. | 133 |
| 29034206 | 2017 | Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia. | 123 |
| 34348000 | 2021 | Role of GATA2 in Human NK Cell Development. | 115 |
| 38422019 | 2024 | Pathogenic GATA2 genetic variants utilize an obligate enhancer mechanism to distort a multilineage differentiation program. | 99 |
| 26356674 | 2015 | The search for cis-regulatory driver mutations in cancer genomes. | 97 |
| 28410882 | 2017 | Epo reprograms the epigenome of erythroid cells. | 89 |
| 37213235 | 2023 | RUNX1 colludes with NOTCH1 to reprogram chromatin in T cell acute lymphoblastic leukemia. | 87 |
| 36044573 | 2022 | Endothelial versus pronephron fate decision is modulated by the transcription factors Cloche/Npas4l, Tal1, and Lmo2. | 82 |
| 37595278 | 2023 | Genome-wide transcription factor-binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs. | 81 |
| 35649376 | 2022 | Differential Etv2 threshold requirement for endothelial and erythropoietic development. | 78 |
| 24290192 | 2014 | Ldb1 complexes: the new master regulators of erythroid gene transcription. | 75 |
| 26882564 | 2016 | microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia. | 74 |
| 33293632 | 2020 | The transcription factor TAL1 and miR-17-92 create a regulatory loop in hematopoiesis. | 74 |
| 20028976 | 2010 | Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1. | 71 |
| 31980609 | 2020 | Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing. | 70 |
| 29713515 | 2018 | The Role of TAL1 in Hematopoiesis and Leukemogenesis. | 70 |
| 32086528 | 2020 | Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis. | 69 |
| 24874575 | 2014 | PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation. | 69 |
| 34933939 | 2022 | Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers. | 68 |
| 21179004 | 2011 | Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages. | 68 |
| 24075907 | 2013 | tal1 Regulates the formation of intercellular junctions and the maintenance of identity in the endocardium. | 65 |
| 20855495 | 2010 | NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. | 62 |
| 39716491 | 2025 | ID3 promotes erythroid differentiation and is repressed by a TAL1-PRMT6 complex. | 62 |
| 32049046 | 2020 | Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis. | 61 |
| 37379322 | 2023 | Isoforms of the TAL1 transcription factor have different roles in hematopoiesis and cell growth. | 61 |
| 23698277 | 2014 | Aberrant TAL1 activation is mediated by an interchromosomal interaction in human T-cell acute lymphoblastic leukemia. | 60 |
| 22310283 | 2012 | Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis. | 59 |
| 30787436 | 2019 | A single-cell molecular map of mouse gastrulation and early organogenesis. | 57 |
| 36217016 | 2022 | Identifying a novel role for the master regulator Tal1 in the Endothelial to Hematopoietic Transition. | 56 |
| 34360789 | 2021 | A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis. | 56 |
| 35508511 | 2022 | The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis. | 54 |
| 26944678 | 2016 | UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia. | 54 |
| 17722983 | 2007 | Early endocardial morphogenesis requires Scl/Tal1. | 54 |
| 26503782 | 2016 | Genome-Wide Organization of GATA1 and TAL1 Determined at High Resolution. | 52 |
| 23857984 | 2013 | The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. | 52 |
| 36073513 | 2023 | Targeting dual oncogenic machineries driven by TAL1 and PI3K-AKT pathways in T-cell acute lymphoblastic leukemia. | 51 |
| 38058200 | 2024 | CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia. | 50 |
| 29654272 | 2018 | Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia. | 50 |
| 38499435 | 2024 | Decoding human in vitro terminal erythropoiesis originating from umbilical cord blood mononuclear cells and pluripotent stem cells. | 49 |
| 29632840 | 2016 | The proto-oncogenic protein TAL1 controls TGF-β1 signaling through interaction with SMAD3. | 48 |
| 36854750 | 2023 | TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN. | 48 |
| 38553571 | 2024 | The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance. | 47 |
| 38249888 | 2023 | Transcription factor-target gene regulatory network analysis in human lung adenocarcinoma. | 47 |
| 25615415 | 2015 | Site- and allele-specific polycomb dysregulation in T-cell leukaemia. | 44 |
| 35354248 | 2022 | TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia. | 43 |
| 16621969 | 2006 | Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. | 42 |
| 36632736 | 2023 | TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3' neo-enhancer. | 41 |
| 29556024 | 2018 | The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia. | 35 |
| 37855064 | 2024 | Regulatory mechanisms and context-dependent roles of TAL1 in T-cell acute lymphoblastic leukemia. | 33 |
| 36800576 | 2023 | Elevated STIL predicts poor prognosis in patients with hepatocellular carcinoma. | 32 |
| 24040098 | 2013 | SIL-TAL1 rearrangement is related with poor outcome: a study from a Chinese institution. | 31 |
| 31949792 | 2018 | A novel TAL1/miR-149* axis accelerates tumor growth of human T cell acute lymphoblastic leukemia. | 26 |
| 35563322 | 2022 | Generation of Inducible BCL11B Knockout in TAL1/LMO1 Transgenic Mouse T Cell Leukemia/Lymphoma Model. | 20 |
| 36650499 | 2023 | Harnessing the MYB-dependent TAL1 5'super-enhancer for targeted therapy in T-ALL. | 15 |
| 36948867 | 2023 | [Clinical features of 19 patients with SIL-TAL1-positive T-cell acute lymphoblastic leukemia]. | 14 |
| 36045064 | 2023 | A Case of STIL-TAL1-positive T-lymphoblastic Leukemia With a Minor Philadelphia-positive Clone. | 11 |
| 38105739 | 2024 | ToTAL1y degraded - rapid dTAG proteolysis of TAL1 in T-cell acute lymphoblastic leukemia. | 11 |
| 39017847 | 2024 | Transcription Factor TAL1 in Erythropoiesis. | 0 |
| 38102337 | 2024 | Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia. | 0 |
| 30145780 | 2019 | Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia. | 0 |
| 28179281 | 2017 | SCL/TAL1: a multifaceted regulator from blood development to disease. | 0 |
| 37591943 | 2023 | TAL1 hijacks MYCN enhancer that induces MYCN expression and dependence on mevalonate pathway in T-cell acute lymphoblastic leukemia. | 0 |
| 28679996 | 2017 | [Transcriptional regulation of erythropoiesis]. | 0 |
| 33483615 | 2021 | T-ALL can evolve to oncogene independence. | 0 |
| 27443261 | 2016 | Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage. | 0 |
| 37591940 | 2023 | S1P-S1PR3-RAS promotes the progression of S1PR3(hi) TAL1(+) T-cell acute lymphoblastic leukemia that can be effectively inhibited by an S1PR3 antagonist. | 0 |
| 8142619 | 1993 | TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia. | 0 |
| 9695959 | 1998 | TAL1 expression does not occur in the majority of T-ALL blasts. | 0 |
| 9230693 | 1997 | The SCL/TAL1 gene: roles in normal and malignant haematopoiesis. | 0 |
| 31493871 | 2019 | TAL1 mediates imatinib-induced CML cell apoptosis via the PTEN/PI3K/AKT pathway. | 0 |
| 36929052 | 2023 | Hematopoietic/erythroid enhancers activate nearby target genes by extending histone H3K27ac and transcribing intergenic RNA. | 0 |
| 24200685 | 2013 | Chromatin looping defines expression of TAL1, its flanking genes, and regulation in T-ALL. | 0 |
| 27342490 | 2016 | [Clinical Characteristics and Treatment Efficacy of Children with SIL/TAL1 Positive T-Cell Acute Lymphoblastic Leukemia]. | 0 |
| 16407836 | 2006 | p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice. | 0 |
| 17962192 | 2008 | Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP. | 0 |
| 25858676 | 2015 | The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells. | 0 |
| 24792110 | 2014 | Targeting epigenetics to speed up repair. | 0 |
| 14582078 | 2003 | Gene expression profiling in T-cell acute lymphoblastic leukemia. | 0 |
| 28685891 | 2017 | Specification of neurotransmitter identity by Tal1 in thalamic nuclei. | 0 |
| 39488662 | 2024 | Transcriptional regulatory program controlled by MYB in T-cell acute lymphoblastic leukemia. | 0 |
| 32835548 | 2020 | SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome. | 0 |
| 25528728 | 2015 | KLF1 stabilizes GATA-1 and TAL1 occupancy in the human β-globin locus. | 0 |
| 7496160 | 1995 | TAL1 gene deletions and TAL1 protein expression in sporadic melanoma. | 0 |
| 17910069 | 2008 | Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12. | 0 |
| 38155245 | 2024 | Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL. | 0 |
| 15193261 | 2004 | TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB. | 0 |
| 21990371 | 2012 | Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP. | 0 |
| 30185409 | 2018 | A novel role for Lyl1 in primitive erythropoiesis. | 0 |
| 10490830 | 1999 | p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein. | 0 |
| 15961517 | 2005 | SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment. | 0 |
| 8350619 | 1993 | SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia. | 0 |
| 15930267 | 2005 | Akt phosphorylates Tal1 oncoprotein and inhibits its repressor activity. | 0 |
| 19587703 | 2009 | Inhibition of the hTERT promoter by the proto-oncogenic protein TAL1. | 0 |
| 16778172 | 2006 | Tal1 transgenic expression reveals absence of B lymphocytes. | 0 |
| 35569185 | 2022 | Hirsutine, a novel megakaryopoiesis inducer, promotes thrombopoiesis via MEK/ERK/FOG1/TAL1 signaling. | 0 |
| 19736520 | 2009 | Transcriptional regulation by TAL1: a link between epigenetic modifications and erythropoiesis. | 0 |
| 9405094 | 1997 | TAL1/SCL is expressed in endothelial progenitor cells/angioblasts and defines a dorsal-to-ventral gradient of vasculogenesis. | 0 |
| 19406989 | 2009 | TGF-beta induces degradation of TAL1/SCL by the ubiquitin-proteasome pathway through AKT-mediated phosphorylation. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9713995 | 1998 | Deregulated expression of the TAL1 gene by t(1;5)(p32;31) in patient with T-cell acute lymphoblastic leukemia. | François S et al |
Citation
Jean-Loup Huret
t(1;5)(p32;q31) ?/TAL1
Atlas Genet Cytogenet Oncol Haematol. 1998-09-01
Online version: http://atlasgeneticsoncology.org/haematological/1141/t(1
