1.Laboratoire d Hématologie, Hôpital du Haut-Lévêque, CHU de Bordeaux, Ave de Magellan, 33 604 Pessac, France2.Laboratoire dHématologie, Hôpital du Haut-Lévêque, CHU de Bordeaux, Ave de Magellan, 33 604 Pessac, France
Putative tumour suppressor gene(s) on chromosome arm 6q remains to be identified; to demonstrate this loss of heterozygosity of informative markers (LOH) was analysed using PCR amplification of polymorphic microsatellite sequences; using polymorphic markers located from the 6q14-15 to telomere, LOH was detected in 5 to 25% of childhood ALL cases.
Regarding LOH results, two distinct regions were identified:- first region flanked by D6S283 and D6S302 loci at 6q21-22- second region flanked by D6S275 and D6S283 loci at 6q21
Using LOH analysis on several cases, the authors demonstrated an identical 6q21-22 structure at diagnosis and at relapse, suggesting that 6q deletion may be an initial event in leukemogenesis and may occur less frequently during progression of the disease.
Chrystele Bilhou-Nabera ; Christophe Brigaudeau
del(6q) abnormalities in lymphoid malignancies
Atlas Genet Cytogenet Oncol Haematol. 1998-12-01
Online version: http://atlasgeneticsoncology.org/haematological/1148/del(6q)-abnormalities-in-lymphoid-malignancies