t(3;5)(q26;q34) ?/MECOM

2007-07-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Acute myeloid leukaemia (AML)

Epidemiology

Only two cases to date, a 48 year old female patient and a male patient of unknown age, both with M2 AML

Prognosis

No data

Genes Involved and Proteins

Note
The partner of EVI1 is yet unknown.
Gene name
MECOM (Ecotropic Viral Integration Site 1 (EVI1) and Myelodysplastic Syndrome 1 (MDS1-EVI1)
Location
3q26.2
Protein description
Transcrition factor; EVI1 targets include:GATA2, ZBTB16 /PLZF, ZFPM2/FOG2, JNK and the PI3K/AKT pathway. Role in cell cycle progression, likely to be cell-type dependant; antiapoptotic factor; involved in neuronal development organogenesis; role in hematopoietic differsntiation

Bibliography

Pubmed IDLast YearTitleAuthors
163421722006EVI1 is consistently expressed as principal transcript in common and rare recurrent 3q26 rearrangements.Poppe B et al
119343872002Cytogenetic analysis in 139 Tunisian patients with de novo acute myeloid leukemia.Sendi HS et al
175071832007The oncogene and developmental regulator EVI1: expression, biochemical properties, and biological functions.Wieser R et al

Summary

Atlas Image
t(3;5)(q26;q34) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.

Citation

Jean-Loup Huret

t(3;5)(q26;q34) ?/MECOM

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/haematological/1278/t(3;5)(q26;q34)

External Links