t(3;5)(q26;q34) ?/MECOM

2007-07-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


Acute myeloid leukaemia (AML)


Only two cases to date, a 48 year old female patient and a male patient of unknown age, both with M2 AML


No data

Genes Involved and Proteins

The partner of EVI1 is yet unknown.
Gene name
MECOM (Ecotropic Viral Integration Site 1 (EVI1) and Myelodysplastic Syndrome 1 (MDS1-EVI1)
Protein description
Transcrition factor; EVI1 targets include:GATA2, ZBTB16 /PLZF, ZFPM2/FOG2, JNK and the PI3K/AKT pathway. Role in cell cycle progression, likely to be cell-type dependant; antiapoptotic factor; involved in neuronal development organogenesis; role in hematopoietic differsntiation


Pubmed IDLast YearTitleAuthors
163421722006EVI1 is consistently expressed as principal transcript in common and rare recurrent 3q26 rearrangements.Poppe B et al
119343872002Cytogenetic analysis in 139 Tunisian patients with de novo acute myeloid leukemia.Sendi HS et al
175071832007The oncogene and developmental regulator EVI1: expression, biochemical properties, and biological functions.Wieser R et al


Atlas Image
t(3;5)(q26;q34) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.


Jean-Loup Huret

t(3;5)(q26;q34) ?/MECOM

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/haematological/1278/t(3;5)(q26;q34)

External Links