i(8)(q10) in acute myeloid leukaemia

2007-03-01 David Betts Affiliation

1.Department of Oncology, University Childrens Hospital, Steinwiesstr. 75, CH-8032 Zò_rich, Switzerland

Clinics and Pathology

Disease

Note

The aberration has also been reported in many other neoplastic disorders, most notably T-prolymphocytic leukaemia (PLL) and acute lymphoblastic leukaemia (ALL). In the latter, it often occurs as a secondary event to the t(9;22).

Phenotype stem cell origin

Has been reported to occur in all AML FAB types, with FAB M2 representing the most common morphology.

Epidemiology

A rare non-random event reported in over 50 cases of AML (below 0.5% of all cases) and occurs in both children and adults.

Prognosis

As the aberration is rare and will frequently occur in complex karyotypes, whether an independent prognosis association can be determined is uncertain.

Cytogenetics

Cytogenetics morphological

In approximately 40% of cases the aberration is reported as a chromosome gain.

Additional anomalies

Seldom occurs as a primary karyotype event. Most often found in complex karyotypes and/or arises in a sub-clone. The complex karyotypes will frequently contain loss of chromosome 5(q) and/or loss of chromosome 7(q).

Bibliography

Pubmed ID	Last Year	Title	Authors
11107171	2001	Cross-species color banding in ten cases of myeloid malignancies with complex karyotypes.	Harrison CJ et al
10706455	1999	Comparative genomic hybridization and conventional cytogenetic analyses in childhood acute myeloid leukemia.	Huhta T et al
17487754	2007	Loss of i(8)(q10) at relapse in two cases of childhood acute myeloid leukaemia.	Seppa L et al
8616020	1996	Deletions of the long arm of chromosome 7 in myeloid disorders: loss of band 7q32 implies worst prognosis.	Velloso ER et al
10991616	2000	Isochromosome 8q is a marker of secondary acute myeloid leukemia.	Wong KF et al

Summary

i(8)(q10) i(8)(q10) TOP: G- banding (left) - Courtesy Melanie Zenger and Claudia Haferlach; R-banding: middle - Courtesy Jean Luc Lai; right Jean Loup Huret. Hybridization with the Vysis LSI RUNX1/RUNX1T1 probes showing extra copies of RUNX1T1 as a result of isochromosome i(8)(q10) (A) and + i(8)(q10) (B) formation (red signals) - Courtesy Adriana Zamecnikova.

Citation

David Betts

i(8)(q10) in acute myeloid leukaemia

Atlas Genet Cytogenet Oncol Haematol. 2007-03-01

Online version: http://atlasgeneticsoncology.org/haematological/1334/i(8)(q10)-in-acute-myeloid-leukaemia