t(1;14)(q21;q32) FCGR2B/IGH
2005-02-01 Jacques Boyer Affiliation1.Laboratoire d hématologie, CH du MANS, France
Clinics and Pathology
Disease
Follicular lymphoma in one CD10+ case, but without a t(14;18)(q32;q21), bcl2 negative, and with a t(1;14)(q21;q32); follicular lymphoma with FCGR2B rearrangement and dup(1)(q21q25)in another case .
Epidemiology
These two cases with FCGR2B rearrangement were found among a panel of 76 non Hodgkins lymphomas.
Prognosis
May be associated with tumor progression.
Genes Involved and Proteins
Gene name
FCGR2B (Fc fragment of IgG, low affinity IIb, receptor (CD32))
Location
1q23.3
Gene name
IGH (Immunoglobulin Heavy)
Location
14q32.33
Result of the Chromosomal Anomaly
Description
The translocation juxtapose the 5 switch region og IGHG2 to a region upstream of FCGR2B in the der(1) chromosome.FCGR2B is deregulated by this translocation and FCGR2B b2 mRNA isoform is overexpressed.
Note
No fusion protein.
Oncogenesis
It is possible that alteration in the b2/b1 mRNA isoforms ratio in B-cells may promote B cell survival. This anomaly is bcl2 deregulation-independant because FCGR2B has been shown to be a tumor-enhancing factor in non lymphoid cells in murine in vivo and in vitro models. Deregulation of FCGR2B expression can be considered as a second event which may impart additional growth advantage to the bcl2 deregulated B-cells.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10618414 | 2000 | The IgG Fc receptor, FcgammaRIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma. | Callanan MB et al |
| 11753646 | 2001 | Deregulation of FCGR2B expression by 1q21 rearrangements in follicular lymphomas. | Chen W et al |
| 11701542 | 2000 | Non-Hodgkin's Lymphoma: Molecular Features of B Cell Lymphoma. | Macintyre E et al |
Citation
Jacques Boyer
t(1;14)(q21;q32) FCGR2B/IGH
Atlas Genet Cytogenet Oncol Haematol. 2005-02-01
Online version: http://atlasgeneticsoncology.org/haematological/1341/t(1
