t(8;12)(q22;q13) HMGA2/?
2005-05-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
myeloproliferative/myelodysplastic syndrome (MPD/MDS)
Epidemiology
only 1 case to date: a 53yr old female patient with atypical chronic myelogenous leukemia (aCML) (with no BCR-ABL rearrangement)
Cytogenetics
sole anomaly in a subclone; accompanied with del(13q) in another one
Genes Involved and Proteins
Gene name
HMGA2 (high mobility group AT-hook 2)
Location
12q14.3
Protein description
probable role in regulation of cell proliferation (transcriptional regulation of cell cycle and DNA repair genes
Result of the Chromosomal Anomaly
Description
ectopic expression of HMGA2
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32365712 | 2020 | High Mobility Group AT-Hook 2 (HMGA2) Oncogenicity in Mesenchymal and Epithelial Neoplasia. | 194 |
| 33668453 | 2021 | HMGA2 as a Critical Regulator in Cancer Development. | 191 |
| 39085703 | 2024 | Decoding high mobility group A2 protein expression regulation and implications in human cancers. | 162 |
| 32466162 | 2020 | The Mammalian High Mobility Group Protein AT-Hook 2 (HMGA2): Biochemical and Biophysical Properties, and Its Association with Adipogenesis. | 156 |
| 38361784 | 2024 | HMGA2 promotes cancer metastasis by regulating epithelial-mesenchymal transition. | 147 |
| 38753081 | 2024 | The emerging role and mechanism of HMGA2 in breast cancer. | 143 |
| 33069103 | 2021 | Emerging roles for HMGA2 in colorectal cancer. | 115 |
| 36835656 | 2023 | Nuclear High Mobility Group A2 (HMGA2) Interactome Revealed by Biotin Proximity Labeling. | 95 |
| 37828010 | 2023 | HMGA2 directly mediates chromatin condensation in association with neuronal fate regulation. | 93 |
| 33749722 | 2021 | Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells. | 90 |
| 24914948 | 2014 | Generation and characterisation of a canine EGFP-HMGA2 prostate cancer in vitro model. | 85 |
| 32898013 | 2020 | High mobility group A protein-2 as a tumor cancer diagnostic and prognostic marker: a systematic review and meta-analysis. | 78 |
| 38304037 | 2023 | HMGA2 promotes nasopharyngeal carcinoma progression and is associated with tumor resistance and poor prognosis. | 75 |
| 38516887 | 2024 | Characterization of HMGA2 variants expands the spectrum of Silver-Russell syndrome. | 74 |
| 27102002 | 2016 | The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma. | 73 |
| 37113783 | 2023 | Novel roles for HMGA2 isoforms in regulating oxidative stress and sensitizing to RSL3-Induced ferroptosis in prostate cancer cells. | 72 |
| 33139812 | 2020 | Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. | 72 |
| 29296743 | 2017 | Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms. | 64 |
| 37445942 | 2023 | Unraveling the Roles of miR-204-5p and HMGA2 in Papillary Thyroid Cancer Tumorigenesis. | 62 |
| 30228296 | 2018 | Hmga2 is dispensable for pancreatic cancer development, metastasis, and therapy resistance. | 59 |
| 38811851 | 2024 | Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditions. | 58 |
| 31619685 | 2019 | N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis. | 57 |
| 35918713 | 2022 | Hmga2 protein loss alters nuclear envelope and 3D chromatin structure. | 57 |
| 25575139 | 2015 | The chromatin-modifying protein HMGA2 promotes atypical teratoid/rhabdoid cell tumorigenicity. | 56 |
| 27259253 | 2016 | HMGA2 sustains self-renewal and invasiveness of glioma-initiating cells. | 56 |
| 38572092 | 2024 | Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis. | 55 |
| 36309352 | 2022 | Fusion of the HMGA2 and BNC2 Genes in Uterine Leiomyoma With t(9;12)(p22;q14). | 54 |
| 24661562 | 2014 | Hmga2 is required for canonical WNT signaling during lung development. | 52 |
| 32489328 | 2020 | Oncogenic role of HMGA2 in fusion-negative rhabdomyosarcoma cells. | 50 |
| 35797243 | 2022 | HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition. | 50 |
| 34976223 | 2022 | HMGA2 facilitates colorectal cancer progression via STAT3-mediated tumor-associated macrophage recruitment. | 49 |
| 28522832 | 2017 | The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2. | 49 |
| 28814752 | 2017 | Oncofetal HMGA2 effectively curbs unconstrained (+) and (-) DNA supercoiling. | 48 |
| 38493165 | 2024 | HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells. | 47 |
| 35340777 | 2022 | HMGA2: A Biomarker in Gynecologic Neoplasia. | 47 |
| 25336737 | 2014 | Hmga2 regulates self-renewal of retinal progenitors. | 46 |
| 38845972 | 2024 | HMGA2 promotes resistance against paclitaxel by targeting the p53 signaling pathway in colorectal cancer cells. | 45 |
| 29109785 | 2017 | Overexpression of miR-194 Reverses HMGA2-driven Signatures in Colorectal Cancer. | 45 |
| 24728959 | 2014 | Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype. | 45 |
| 28752530 | 2017 | HMGA2 regulates lung cancer proliferation and metastasis. | 44 |
| 34878116 | 2022 | Hmga2 deficiency is associated with allometric growth retardation, infertility, and behavioral abnormalities in mice. | 44 |
| 35388973 | 2022 | Expression and Clinical Significance of High-Mobility Group AT-hook 2 (HMGA2) in Osteosarcoma. | 44 |
| 33307962 | 2021 | HMGA2 promotes breast cancer metastasis by modulating Hippo-YAP signaling pathway. | 44 |
| 23722545 | 2013 | HMGA2 is a driver of tumor metastasis. | 41 |
| 32719345 | 2020 | HMGA2 regulates circular RNA ASPH to promote tumor growth in lung adenocarcinoma. | 40 |
| 34680349 | 2021 | HMGA2 Supports Cancer Hallmarks in Triple-Negative Breast Cancer. | 39 |
| 29733521 | 2018 | HMGA2 promotes glioma invasion and poor prognosis via a long-range chromatin interaction. | 39 |
| 33315504 | 2020 | The pro-migration and anti-apoptosis effects of HMGA2 in HUVECs stimulated by hypoxia. | 38 |
| 33237328 | 2021 | HMGA2-induced epithelial-mesenchymal transition is reversed by let-7d in intrauterine adhesions. | 37 |
| 36180890 | 2022 | Knockdown circTRIM28 enhances tamoxifen sensitivity via the miR-409-3p/HMGA2 axis in breast cancer. | 37 |
| 33986248 | 2021 | A KLF4/PiHL/EZH2/HMGA2 regulatory axis and its function in promoting oxaliplatin-resistance of colorectal cancer. | 36 |
| 32868105 | 2020 | HMGA2-mediated tumorigenesis through angiogenesis in leiomyoma. | 35 |
| 28415789 | 2017 | Hmga2 translocation induced in skin tumorigenesis. | 35 |
| 39447278 | 2024 | HMGA2 regulates GPX4 expression and ferroptosis in prostate cancer cells. | 34 |
| 34115920 | 2021 | CSNK2A1-mediated phosphorylation of HMGA2 modulates cisplatin resistance in cervical cancer. | 33 |
| 35966335 | 2022 | HMGA2 Promotes Brain Injury in Rats with Cerebral Infarction by Activating TLR4/NF-κB Signaling Pathway. | 32 |
| 38449630 | 2024 | HMGA2 overexpression activates IGF2BP2 to stabilize APLP2 via m6A modification and promote pancreatic cancer progression. | 25 |
| 38112616 | 2023 | LncRNA HAGLROS contribute to papillary thyroid cancer progression by modulating miR-206/HMGA2 expression. | 25 |
| 28356845 | 2015 | HMGA2 Expression in Renal Carcinoma and its Clinical Significance. | 22 |
| 32780494 | 2020 | Biomarker function of HMGA2 in ultraviolet-induced skin cancer development. | 21 |
| 38840187 | 2024 | Pathogenic sequence variant and microdeletion affecting HMGA2 in Silver-Russell syndrome: case reports and literature review. | 10 |
| 26901496 | 2016 | Hmga2 is dispensable for cutaneous squamous cell carcinoma. | 8 |
| 31432151 | 2019 | Oncological role of HMGA2 (Review). | 0 |
| 23686260 | 2013 | HMGA2 and high-grade serous ovarian carcinoma. | 0 |
| 30305510 | 2018 | [The role of HMGA2 in myeloproliferative neoplasms]. | 0 |
| 36931542 | 2023 | HMGA2 regulation by miRNAs in cancer: Affecting cancer hallmarks and therapy response. | 0 |
| 39680021 | 2025 | HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma. | 0 |
| 39089476 | 2024 | Beneath HMGA2 alterations in pleomorphic adenomas: Pathological, immunohistochemical, and molecular insights. | 0 |
| 39222752 | 2024 | CircRNAs as upstream regulators of miRNA//HMGA2 axis in human cancer. | 0 |
| 37698344 | 2024 | A novel HMGA2::KITLG fusion in a dedifferentiated liposarcoma with amplification of MDM2 and HMGA2. | 0 |
| 34547256 | 2021 | HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production. | 0 |
| 39278426 | 2024 | Insights into the molecular alterations of PLAG1 and HMGA2 associated with malignant phenotype acquisition in pleomorphic adenoma. | 0 |
| 36116352 | 2022 | HMGA2 mediates Cr (VI)-induced metabolic reprogramming through binding to mitochondrial D-Loop region. | 0 |
| 34973532 | 2022 | High mobility group AT-hook 2 regulates osteoblast differentiation and facial bone development. | 0 |
| 37997502 | 2023 | LINC02454 promotes thyroid carcinoma progression via upregulating HMGA2 through CREB1. | 0 |
| 32592217 | 2020 | An HMGA2-p62-ERα axis regulates uterine leiomyomas proliferation. | 0 |
| 35764101 | 2022 | HMGA2-Snai2 axis regulates tumorigenicity and stemness of head and neck squamous cell carcinoma. | 0 |
| 33744765 | 2021 | Methylation-dependent SUMOylation of the architectural transcription factor HMGA2. | 0 |
| 11576996 | 2001 | Role of the high mobility group A proteins in human lipomas. | 0 |
| 28710822 | 2017 | Prevalence and significance of HMGA2 expression in oesophageal adenocarcinoma. | 0 |
| 36825504 | 2023 | Green Tea Epigallocatechin Gallate Inhibits Preadipocyte Growth via the microRNA-let-7a/HMGA2 Signaling Pathway. | 0 |
| 26966068 | 2016 | HMGA2 promotes adipogenesis by activating C/EBPβ-mediated expression of PPARγ. | 0 |
| 28510366 | 2017 | HMGA2 plays an important role in Cr (VI)-induced autophagy. | 0 |
| 36564076 | 2022 | HMGA2 Synergizes with EZH2 to Mediate Epithelial Cell Inflammation and Apoptosis in Septic Lung Dysfunction. | 0 |
| 34481905 | 2021 | A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration. | 0 |
| 32421827 | 2020 | HMGA2 Variants in Silver-Russell Syndrome: Homozygous and Heterozygous Occurrence. | 0 |
| 30825204 | 2019 | HMGA2 and Bach-1 cooperate to promote breast cancer cell malignancy. | 0 |
| 39032683 | 2024 | HMGA2-mediated glutamine metabolism is required for Cd-induced cell growth and cell migration. | 0 |
| 16969098 | 2006 | Critical role of the HMGA2 gene in pituitary adenomas. | 0 |
| 35367424 | 2022 | The proteasome activator REGγ promotes diabetic endothelial impairment by inhibiting HMGA2-GLUT1 pathway. | 0 |
| 26319392 | 2016 | Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML. | 0 |
| 13679031 | 2003 | Hmga2 promoter analysis in transgenic mice. | 0 |
| 19528502 | 2009 | Expression of HMGA2-LPP and LPP-HMGA2 fusion genes in lipoma: identification of a novel type of LPP-HMGA2 transcript in four cases. | 0 |
| 30175854 | 2018 | HMGA2 promotes intestinal tumorigenesis by facilitating MDM2-mediated ubiquitination and degradation of p53. | 0 |
| 26806704 | 2016 | Hmga2 is required for neural crest cell specification in Xenopus laevis. | 0 |
| 30137214 | 2019 | HMGA2 is regulated by LIN28 and BRCA1 in human placental cells. | 0 |
| 37268162 | 2023 | HMGA2 knockdown alleviates the progression of nonalcoholic fatty liver disease (NAFLD) by downregulating SNAI2 expression. | 0 |
| 30999005 | 2019 | Differential Expression of HMGA1 and HMGA2 in pituitary neuroendocrine tumors. | 0 |
| 33111425 | 2021 | Prognostic significance of the MDM2/HMGA2 ratio and histological tumor grade in dedifferentiated liposarcoma. | 0 |
| 30017537 | 2018 | HMGA2 and MED12 alterations frequently co-occur in uterine leiomyomas. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 15618963 | 2005 | Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies. | Odero MD et al |
Citation
Jean-Loup Huret
t(8;12)(q22;q13) HMGA2/?
Atlas Genet Cytogenet Oncol Haematol. 2005-05-01
Online version: http://atlasgeneticsoncology.org/haematological/1389/t(8
