myelodysplastic/myeloproliferative syndrome, unclassifiable

only 1 case to date: a 67 yr old female patient without BCR-ABL rearrangement

basophilia (10%) and bone marrow fibrosis

additional anomaly: add(6)

survival: 20 mths+; largely asymptomatic

HMGA2 exon 3 spliced to intron 3 of the gene and an alternative product with exon 2 spliced to intron 2truncated HMGA2 (normal exons 1 to 3 followed by 7 amino acids from intron 3 and normal exons 1-2plus 15 amino acids from intron 2); ectopic expression of HMGA2