t(7;17)(q32-34;q23) MSI2/?

2005-08-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


Chronic myelogenous leukemia (CML) in accelerated phase (AP-CML)


only one case to date, a female patient, aged a 40 at the time of the AP-CML


Chronic phase of CML lasted 2 yrs before progression into an accelerated phase accompanied with the appearance of the t(7;17); 2 mths later, a blast crisis occurred, and the patient died 9 mths after the AP-CML, 33 mths after initial diagnosis of CML.


Cytogenetics morphological

at(9;22)(q34;q11) was, indeed, present

Cytogenetics molecular

Cryptic translocation; recognized by multicolor FISH plus locus-specific FISH

Genes Involved and Proteins

The gene involved on chromosome 7 is undefined, due to a lack of material for further analysis, but it seems to be a gene of the plexin family, with, perhaps, a sema domain, a plexin repeat, and an immunoglobulin-like plexin transcription factor domain
Gene name
MSI2 (musashi homolog 2 (drosophila))
Dna rna description
at least 15 exons; various splicing.
Protein description
possesses 2 RNA recognition motifs; likely to be a RNA binding protein; may play a role in RNA metabolism in the cytoplasm; The mouse homolog is ubiquitous, and particularly active in the brain development.

Highly cited references

Pubmed IDYearTitleCitations
304199482018Long non-coding RNA DANCR promotes malignant phenotypes of bladder cancer cells by modulating the miR-149/MSI2 axis as a ceRNA.46
312174282019Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.37
319525412020Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling.30
297626352018An Epigenome-Wide Association Study of Obesity-Related Traits.26
328553912020RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction.23
324084942020RNA-Binding Proteins in Acute Leukemias.17
322933322020Right and left-sided colon cancers - specificity of molecular mechanisms in tumorigenesis and progression.16
310661202019MicroRNA-143/Musashi-2/KRAS cascade contributes positively to carcinogenesis in human bladder cancer.16
303676642018Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease.16
318886852019Musashi2 contributes to the maintenance of CD44v6+ liver cancer stem cells via notch1 signaling pathway.15
298958192018Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations.14
328281262020Integrated analysis of RNA-binding proteins in human colorectal cancer.13
301268422018Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling.13
323327292020HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells.12
306045022019USP10 regulates Musashi-2 stability via deubiquitination and promotes tumour proliferation in colon cancer.12
316930872019Emerging roles of the long non-coding RNA 01296/microRNA-143-3p/MSI2 axis in development of thyroid cancer.11
300970322018Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.11
290544892017Msi2 plays a carcinogenic role in esophageal squamous cell carcinoma via regulation of the Wnt/β-catenin and Hedgehog signaling pathways.11
328487392020Construction and Analysis of the Tumor-Specific mRNA-miRNA-lncRNA Network in Gastric Cancer.10
318336122020RNA-binding protein Musashi2 stabilizing androgen receptor drives prostate cancer progression.10
323557232020Activating miRNA-mRNA network in gemcitabine-resistant pancreatic cancer cell associates with alteration of memory CD4+ T cells.10
327798762020Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway.8
330615722020Knockdown of MIR4435-2HG Suppresses the Proliferation, Migration and Invasion of Cervical Cancer Cells via Regulating the miR-128-3p/MSI2 Axis in vitro.8
310531522019Knockdown of HMGA2 regulates the level of autophagy via interactions between MSI2 and Beclin1 to inhibit NF1-associated malignant peripheral nerve sheath tumour growth.8
312533952019ETV4 promotes proliferation and invasion of lung adenocarcinoma by transcriptionally upregulating MSI2.8
308540352019Increased musashi 2 expression indicates a poor prognosis and promotes malignant phenotypes in gastric cancer.8
296419912018PLAG1 and USF2 Co-regulate Expression of Musashi-2 in Human Hematopoietic Stem and Progenitor Cells.8
295562942018Musashi-2 is a prognostic marker for the survival of patients with cervical cancer.8
319578182020MicroRNA-149 suppresses the malignant phenotypes of ovarian cancer via downregulation of MSI2 and inhibition of PI3K/AKT pathway.7
337802632021LncRNA TUG1 promotes Ewing's sarcoma cell proliferation, migration, and invasion via the miR-199a-3p-MSI2 signaling pathway.6
326333422020LncRNA DANCR regulates osteosarcoma migration and invasion by targeting miR-149/MSI2 axis.6
323195532020Suppression of Musashi‑2 by the small compound largazole exerts inhibitory effects on malignant cells.6
291711812018Regulation of cell proliferation in the retinal pigment epithelium: Differential regulation of the death-associated protein like-1 DAPL1 by alternative MITF splice forms.6
292909732017Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket.6
337079532021Prognostic Value and Biological Functions of RNA Binding Proteins in Stomach Adenocarcinoma.5
324482692020RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer.5
316035832020Crystal and solution structures of human oncoprotein Musashi-2 N-terminal RNA recognition motif 1.5
317389082020Upregulation of microRNA-143-3p induces apoptosis and suppresses proliferation, invasion, and migration of papillary thyroid carcinoma cells by targeting MSI2.5
315955742020SNP rs710886 A>G in long noncoding RNA PCAT1 is associated with the risk of endometriosis by modulating expression of multiple stemness-related genes via microRNA-145 signaling pathway.5
338419302021Musashi 2 (MSI2) expression as an independent prognostic biomarker in non-small cell lung cancer (NSCLC).4
331686292021The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice.4
337232472021Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC).4
327844942020Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction.4
326062892020Knockdown of MSI2 inhibits metastasis by interacting with caveolin-1 and inhibiting its ubiquitylation in human NF1-MPNST cells.4
316921352020Interplay between the RNA binding-protein Musashi and developmental signaling pathways.4
312501542019MSI2-TGF-β/TGF-β R1/SMAD3 positive feedback regulation in glioblastoma.4
335509192022Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factors.3
348778142022Msi2-mediated MiR7a-1 processing repression promotes myogenesis.3
342241762021Time-resolved proteomic profiling of cigarette smoke-induced experimental chronic obstructive pulmonary disease.3
341459292021MUSASHI-2 confers resistance to third-generation EGFR-tyrosine kinase inhibitor osimertinib in lung adenocarcinoma.3
327801972020RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer.3
316948542020Genetic Interactions Affect Lung Function in Patients with Systemic Sclerosis.3
318708442020Genomic and transcriptomic features of dermatofibrosarcoma protuberans: Unusual chromosomal origin of the COL1A1-PDGFB fusion gene and synergistic effects of amplified regions in tumor development.3
318780372019Immunohistochemical Analysis Revealed a Correlation between Musashi-2 and Cyclin-D1 Expression in Patients with Oral Squamous Cells Carcinoma.3
350734592022LncRNA LINC00942 promotes chemoresistance in gastric cancer by suppressing MSI2 degradation to enhance c-Myc mRNA stability.2
344643512021ADGRG1 enriches for functional human hematopoietic stem cells following ex vivo expansion-induced mitochondrial oxidative stress.2
336231422021Identification of gene targets of mutant C/EBPα reveals a critical role for MSI2 in CEBPA-mutated AML.2
343223862021Downregulation of SOX2-OT Prevents Hepatocellular Carcinoma Progression Through miR-143-3p/MSI2.2
340709012021Syndecan-1 Depletion Has a Differential Impact on Hyaluronic Acid Metabolism and Tumor Cell Behavior in Luminal and Triple-Negative Breast Cancer Cells.2
340474772021Glioma glycolipid metabolism: MSI2-SNORD12B-FIP1L1-ZBTB4 feedback loop as a potential treatment target.2
324223512020Evolutionary analysis of the Musashi family: What can it tell us about Zika?2
328737812020Identification of de novo mutations in prenatal neurodevelopment-associated genes in schizophrenia in two Han Chinese patient-sibling family-based cohorts.2
332439882020A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia.2
325074702020Corrigendum to Upregulation of microRNA-143-3p induces apoptosis and suppresses proliferation, invasion, and migration of papillary thyroid carcinoma cells by targeting MSI2. [Experimental and Molecular Pathology volume: 112 start page-end page 104342. doi: 10.1016/j.yexmp.2019.104342].2
300342432018MSI2 knockdown represses extrahepatic cholangiocarcinoma growth and invasion by inhibiting epithelial-mesenchymal transition.2
288848222018RNA binding protein Musashi-2 regulates PIWIL1 and TBX1 in mouse spermatogenesis.2
356163182022Adipocytes-Derived Exosomal microRNA-1224 Inhibits M2 Macrophage Polarization in Obesity-Induced Adipose Tissue Inflammation via MSI2-Mediated Wnt/β-Catenin Axis.1
353012802022The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling.1
343098752021Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue.1
351022502022RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7.1
350038952022CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition.1
345892842021Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression.1
335049422021Musashi 2 influences chronic lymphocytic leukemia cell survival and growth making it a potential therapeutic target.1
337316772021Splicing reprogramming of TRAIL/DISC-components sensitizes lung cancer cells to TRAIL-mediated apoptosis.1
333734402021Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi.1
328238792020Microstructure and Composition Evolution of a Fused Slurry Silicide Coating on MoNbTaTiW Refractory High-Entropy Alloy in High-Temperature Oxidation Environment.1
307267132019PTBP2 exon 10 inclusion is associated with the progression of CML and it is BCR-ABL1 dependent.1
310597352019Musashi-2 and related stem cell proteins in the mouse suprachiasmatic nucleus and their potential role in circadian rhythms.1
288668492017Association of MSI2 Gene Polymorphism with Age-at-Onset of Schizophrenia in a Chinese Population.1
355803852022KLF4 suppresses the proliferation and metastasis of NSCLC cells via inhibition of MSI2 and regulation of the JAK/STAT3 signaling pathway.0
358407002022Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.0
355898672022Evaluation of cfDNA as an early detection assay for dense tissue breast cancer.0
355455362022Overexpression of lncRNA HCP5 in human umbilical cord mesenchymal stem cell-derived exosomes promoted the proliferation and inhibited the apoptosis of ovarian granulosa cells via the musashi RNA-binding protein 2/oestrogen receptor alpha 1 axis.0
354268122022[Advances in research of Musashi2 in solid tumors].0
350212162022Mechanisms modulating the activities of intestinal stem cells upon radiation or chemical agent exposure.0
351537522021Small Molecule Palmatine Targeting Musashi-2 in Colorectal Cancer.0
355282002022Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2).0
345814572021MSI2 expression in adrenocortical carcinoma: Association with unfavorable prognosis and correlation with steroid and immune-related pathways.0
353826832022Single nucleotide polymorphisms (SNPs) and indels identified from whole-genome re-sequencing of four Chinese donkey breeds.0
331314122022Unravelling the drugability of MSI2 RNA recognition motif (RRM) protein and the prediction of their effective antileukemia inhibitors from traditional herb concoctions.0
350187102022Screening and Understanding Lattice Silicon-Controlled Catalytically Active Site Motifs from a Library of Transition Metal-Silicon Intermetallics.0
349440512021Double-Stranded RNA Structural Elements Holding the Key to Translational Regulation in Cancer: The Case of Editing in RNA-Binding Motif Protein 8A.0
348627572021Distinct noncoding RNAs and RNA binding proteins associated with high-risk pediatric and adult acute myeloid leukemias detected by regulatory network analysis.0
336092832021Myofibroblast-Specific Msi2 Knockout Inhibits HCC Progression in a Mouse Model.0
342370572021Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression.0
335532412020RNA-Binding Protein MSI2 Binds to miR-301a-3p and Facilitates Its Distribution in Mitochondria of Endothelial Cells.0
327955892021Integrated genetic and epigenetic analyses uncover MSI2 association with allergic inflammation.0
337628292021Potential Role of Musashi-2 RNA-Binding Protein in Cancer EMT.0
332312032020Electronic, phononic and superconducting properties of trigonal Li2 MSi2 (M = Ir, Rh).0
327372852020Correction: Knockdown of MSI2 inhibits metastasis by interacting with caveolin-1 and inhibiting its ubiquitylation in human NF1-MPNST cells.0


Pubmed IDLast YearTitleAuthors
156805822005Vertebrate 2xRBD hnRNP proteins: a comparative analysis of genome, mRNA and protein sequences.Akindahunsi AA et al
126491772003A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23).Barbouti A et al
124071782002RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation.Sakakibara S et al


Jean-Loup Huret

t(7;17)(q32-34;q23) MSI2/?

Atlas Genet Cytogenet Oncol Haematol. 2005-08-01

Online version: http://atlasgeneticsoncology.org/haematological/1402/t(7;17)(q32-34;q23)

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