MSI2 (musashi homolog 2 (drosophila))

2005-08-01   Jean-Loup Huret  

Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
MSI2
LOCATION
17q22
LOCUSID
124540
ALIAS
MSI2H
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

The gene spans 424 kb.on plus strand; at least 15 exons.

Transcription

alternate splicing; at least 3 transcripts, of which are transcripts of 1,6 and 2,1 kb.

Proteins

Atlas Image

Description

328 amino acids, 35 kDa, and 251 amino acidsThe Musashi (Msi) family genes possess 2 ribonucleoprotein (RNP or ribonucleo particle)-type RNA recognition motifs (RRMs) in the N-term; each RRM comprises 2 highly conserved sequences called RNP1 and RNP2. Heterogeneous nuclear ribonucleoparticle (hnRNP) proteins are nuclear proteins implicated in hnRNA (pre-mRNA transcript) processing; Msi2 and Msi1 have similar RNA-binding specificity.

Expression

Ubiquitously expressed in various tissues; expressed predominently in precursor cells in the ventricular zone and subventricular zone of the central nervous system (CNS); in CNS stem cells during embryogenesis; in the postnatal and adult CNS, the expression of Msi2 and Msi1 disappear in most post mitotic or migrating cells, but is found in cells of the astrocyte lineage; coexpressed with Msi1.

Function

RNA-binding protein. Some RNA-binding proteins are neural-specific. The development of neural cells from precursors may be partly regulated at the post-transcriptional level by mRNA stabilization or translational control in the cytoplasm. Msi2 may have a unique role in CNS stem cells through life.

Homology

MSI1

Mutations

Germinal

Defective MSI2 might play a role in certain dementia (although this chromosomal region also contain several loci known to be involved in neurological disorders ( NF1 and others).

Somatic

see below.

Implicated in

Entity name
Chronic myelogenous leukemia (CML) in accelerated phase (AP-CML) with either a t(7;17)(p15;q23) and a HOXA9 / MSI2 hybrid gene, or a t(7;17)(q32-34;q23) and a ? possible gene of the plexin family/MSI2 hybrid gene.
Hybrid gene
5 MSI2 - 3 HOXA9 in the t(7;17)(p15;q23)
Oncogenesis
In the t(7;17)(p15;q23) the fusion protein contains, from N-term to C-term, the 2 RNA recognition motifs of MSI2 and the the IME and the homeobox domain of HOXA9

Article Bibliography

Pubmed IDLast YearTitleAuthors
156805822005Vertebrate 2xRBD hnRNP proteins: a comparative analysis of genome, mRNA and protein sequences.Akindahunsi AA et al
126491772003A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23).Barbouti A et al
124071782002RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation.Sakakibara S et al

Other Information

Locus ID:

NCBI: 124540
MIM: 607897
HGNC: 18585
Ensembl: ENSG00000153944

Variants:

dbSNP: 124540
ClinVar: 124540
TCGA: ENSG00000153944
COSMIC: MSI2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153944ENST00000284073Q96DH6
ENSG00000153944ENST00000322684Q96DH6
ENSG00000153944ENST00000416426B4DHE8
ENSG00000153944ENST00000442934B4DM51
ENSG00000153944ENST00000579180Q96DH6
ENSG00000153944ENST00000579590J3KTC1
ENSG00000153944ENST00000581776J3QKT5

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378017082024Clonal evolution dissection reveals that a high MSI2 level promotes chemoresistance in T-cell acute lymphoblastic leukemia.1
383476002024Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration.0
378017082024Clonal evolution dissection reveals that a high MSI2 level promotes chemoresistance in T-cell acute lymphoblastic leukemia.1
383476002024Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration.0
363459382023The TGF-β/Smad(2/3) signaling pathway is involved in Musashi2-induced invasion and metastasis of colorectal cancer.1
374818232023Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.2
363459382023The TGF-β/Smad(2/3) signaling pathway is involved in Musashi2-induced invasion and metastasis of colorectal cancer.1
374818232023Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.2
355455362022Overexpression of lncRNA HCP5 in human umbilical cord mesenchymal stem cell-derived exosomes promoted the proliferation and inhibited the apoptosis of ovarian granulosa cells via the musashi RNA-binding protein 2/oestrogen receptor alpha 1 axis.2
358407002022Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.5
361678292022TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.6
365960172022Prognostic value of MSI2 expression in human malignancies: A PRISMA-compliant meta-analysis.1
355455362022Overexpression of lncRNA HCP5 in human umbilical cord mesenchymal stem cell-derived exosomes promoted the proliferation and inhibited the apoptosis of ovarian granulosa cells via the musashi RNA-binding protein 2/oestrogen receptor alpha 1 axis.2
358407002022Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.5
361678292022TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.6

Citation

Jean-Loup Huret

MSI2 (musashi homolog 2 (drosophila))

Atlas Genet Cytogenet Oncol Haematol. 2005-08-01

Online version: http://atlasgeneticsoncology.org/gene/42893/msi2-(musashi-homolog-2-(drosophila))