t(6;11)(q15;q23) KMT2A/?

2009-03-01   Jong Rak Choi , Tae Sung Park 

1.Department of Laboratory Medicine, Kyung Hee University College of Medicine, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea (TSP); Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea (JRC)

Clinics and Pathology


Only 4 cases to date, 3 of which do not provide further descriptions.

Phenotype stem cell origin

All cases were acute myeloid leukaemia (AML); AML-M0 (1 case), AML-M2 (1 case), AML-M4 (2 cases).


All patients were female between the ages of 13 to 68 years.
Atlas Image
Multi-color FISH image showing t(6;11)(q15;q23).
Atlas Image
Bone marrow morphology from AML-M2 case with t(6;11)(q15;q23).


Very poor in 1 case (survival : only 2 weeks in AML-M2).


Cytogenetics morphological

It shows distinct balanced chromosomal abnormalities between chromosomes 6 and 11; however, it should be differentiated from t(6;11)(q13;q23) in association with MLL/ SMAP1 rearrangement.

Cytogenetics molecular

MLL breakapart FISH probe is very useful.

Additional anomalies

del(5)(q13q15) in 1 case, sole abnormality in remaining 3 cases.

Genes Involved and Proteins

The gene involved in 6q15 is unknown.
Gene name
KMT2A (myeloid/lymphoid or mixed lineage leukemia)
More than 50 different translocation fusion partners in association with the MLL gene have been reported in the literature. In chromosome 6, t(6;11)(q27;q23) (MLL/AF6 rearrangement) is the most commonly encountered chromosomal abnormality. In contrast, t(6;11)(q13;q23) or t(6;11)(q15;q23) is the rarest type of MLL rearrangement involving the long arm of chromosome 6.


Pubmed IDLast YearTitleAuthors
156267572005Diagnostic tool for the identification of MLL rearrangements including unknown partner genes.Meyer C et al
189833032008Comparison of multiplex reverse transcription polymerase chain reaction and conventional cytogenetics as a diagnostic strategy for acute leukemia.Park JS et al
189926432008MLL rearrangement with t(6;11)(q15;q23) as a sole abnormality in a patient with de novo acute myeloid leukemia: conventional cytogenetics, FISH, and multicolor FISH analyses for detection of rare MLL-related chromosome abnormalities.Park TS et al
159213752005Analysis of balanced rearrangements of chromosome 6 in acute leukemia: clustered breakpoints in q22-q23 and possible involvement of c-MYB in a new recurrent translocation, t(6;7)(q23;q32 through 36).Sinclair P et al
81238531994Analysis of treatment failure in patients with minimally differentiated acute myeloid leukemia (AML-M0).Stasi R et al


Atlas Image
Giemsa-banding partial karyograms of t(6;11)(q15;q23). (Each left side chromosomes 6 and 11: normal, each right side chromosomes 6 and 11: derivative chromosome).


Jong Rak Choi ; Tae Sung Park

t(6;11)(q15;q23) KMT2A/?

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/haematological/1522/t(6;11)(q15;q23)

External Links