inv(18)(p11q21)

2008-06-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Myelodysplastic syndrome and non Hodgkin lymphoma.

Epidemiology

Four cases are available to date: an indolent B-cell follicular lymphoma, a non Hodgkin lymphoma (NHL) not otherwise specified (NOS), a refractory anemia (RA) possibly related to the treatment of a multiple myeloma diagnosed 4 years before, and a refractory anemia with excess of blasts in transformation (RAEB-t) evolving rapidly towards an acute myeloid leukemia (AML). There were 2 male and 2 female patients, aged 70, 70, 76 and ? (Fan et al., 1988; Avanzi et al., 1989; Fan and Rizkalla, 2003; Adeyinka et al., 2007).

Prognosis

Data on (short term) evolution is only available in the two myeloid cases: the RA case remained well 4 months after diagnosis, while the RAEB-t/AML case died shortly after diagnosis.

Genes Involved and Proteins

Note
Genes involved in this structural anomaly are unknown.

Bibliography

Pubmed IDLast YearTitleAuthors
173213292007Loss of 17p is a major consequence of whole-arm chromosome translocations in hematologic malignancies.Adeyinka A et al
27923251989Trisomy 11 in myelodysplastic syndrome-derived acute myeloblastic leukaemias.Avanzi GC et al
34220381988An acquired Robertsonian translocation dic(14;14)(p11;p11) in a patient with a myelodysplastic syndrome following treatment of multiple myeloma.Fan YS et al
127421582003Comprehensive cytogenetic analysis including multicolor spectral karyotyping and interphase fluorescence in situ hybridization in lymphoma diagnosis. a summary of 154 cases.Fan YS et al

Summary

Note

The anomaly is found in heterogeneous diseases, but the cases present some surprisingly similar cytogenetic features.

Citation

Jean-Loup Huret

inv(18)(p11q21)

Atlas Genet Cytogenet Oncol Haematol. 2008-06-01

Online version: http://atlasgeneticsoncology.org/haematological/1545/inv(18)(p11q21)

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