1.Kuwait Cancer control Center, Department of Hematology, Kuwait; email@example.com
In classic APL (acute promyelocytic leukemia), the central leukemia-initiating event is the fusion between the promyelocytic leukemia (PML) and the retinoic acid receptor alpha (RARA) gene, that arise as a result of t(15;17)(q22;q21) chromosomal translocation. In variant forms of APL, RARA gene have other translocation partners than PML resulting in various molecular characteristics and sensitivities to all-trans-retinoic acid (ATRA) therapy. The variant t(3;17)(q26;q21) translocation, in which RARA is fused to TBL1XR1 (transducin beta like 1 X-linked receptor 1, TBLR1) is a rare anomaly, observed only in sporadic cases.
Atlas Genet Cytogenet Oncol Haematol. 2017-03-01
Online version: http://atlasgeneticsoncology.org/haematological/1602/t(3;17)(q26;q12-21)-tbl1xr1-rara