t(3;6)(q27;q15) ?/BCL6

2012-11-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology


Non Hodgkin lymphoma


The t(3;6) was found in two cases of follicular lymphoma (Sanger et al., 1987; Sanchez-Izquierdo et al., 2001).


The patient reported by Sanger et al., 1987 was a 83-year-old female patient with a follicular mixed small clived and large cell lymphoma, which evolved to a diffuse mixed small lymphocytic and large cell lymphoma. She experienced persistent disease under treatment, refused further chemotherapy, and died two years after diagnosis.

Genes Involved and Proteins

The partner of BCL6 in this translocation is unknown.
Gene name
BCL6 (B-Cell Lymphoma 6)
Protein description
706 amino acids; composed of a NH2-term BTB/POZ domain (amino acids 1-130 (32-99 according to Swiss-Prot) which mediates homodimerization and protein-protein interactions with other corepressors (including HDAC1 and NCOR2/SMRT to constitute a large repressing complex, another transcription repression domain (191-386), PEST sequences (300-417) with a KKYK motif (375-379), and six zinc finger at the C-term (518-541, 546-568, 574-596, 602-624, 630-652, 658-681), responsible for sequence specific DNA binding. Transcription repressor; recognizes the consensus sequence: TTCCT(A/C)GAA (Albagli-Curiel, 2003). Role in germinal centers of lymphoid follicles. BCL6 prevents ATM and TP53 to induce apoptosis in response to DNA rearrangements such as somatic hypermutation and class switch recombination. Therefore essential for normal B cell development.

Highly cited references

Pubmed IDYearTitleCitations
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357172852022B-cell lymphoma 6 (BCL6) testing before in vitro fertilization as a predictor of failure.0
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356975332022Reply of the Authors: B-cell Lymphoma 6 (BCL6) Testing Before In Vitro Fertilization as a Predictor of Failure.0
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350457982022High grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangements: unraveling the genetic landscape of a rare aggressive subtype of non-Hodgkin lymphoma.0
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356466712022Case Report: Intravascular Large B-Cell Lymphoma: A Clinicopathologic Study of Four Cases With Review of Additional 331 Cases in the Literature.0
356409662022BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis.0
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356371032022BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen.0
356258542022Intrapericardial Administration of Secretomes from Menstrual Blood-Derived Mesenchymal Stromal Cells: Effects on Immune-Related Genes in a Porcine Model of Myocardial Infarction.0
356079252022Intestinal occlusion due to Burkitt lymphoma: an unusual cause.0
356001782022Immunohistochemical expression of transcription factors PAX5, OCT2, BCL6 and transcription regulator P53 in Non-Hodgkin lymphomas: A diagnostic cross-sectional study.0
355687242022Primary intradural extramedullary spinal Burkitt's lymphoma mimicking a nerve sheath tumor: a case report.0
355219142022ALK-positive Large B-Cell Lymphoma Presenting as a Circumscribed Breast Mass with Germinal Center Immunophenotype.0
354990822022Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus.1
354440272022The Aryl Hydrocarbon Receptor Modulates T Follicular Helper Cell Responses to Influenza Virus Infection in Mice.0
351498452022Activation and expansion of T-follicular helper cells in chronic lymphocytic leukemia nurselike cell co-cultures.0
351033142022T peripheral helper cells in autoimmune diseases.0
354935152022Providing a Helping Hand: Metabolic Regulation of T Follicular Helper Cells and Their Association With Disease.0
354899632022ABCs of ADCs in management of relapsed/refractory diffuse large B-cell lymphoma.0
354845512022Transcriptional inhibition of miR-486-3p by BCL6 upregulates Snail and induces epithelial-mesenchymal transition during radiation-induced pulmonary fibrosis.0
354800932022Identification of a 12-Gene Signature and Hub Genes Involved in Kidney Wilms Tumor via Integrated Bioinformatics Analysis.0
354369842022B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36.0
353576542022BCL6 and the Notch pathway: a signaling axis leading to a novel druggable biotarget in triple negative breast cancer.0
352475452022The FOXP3 full-length isoform controls the lineage-stability of CD4+FOXP3+ regulatory T cells.0
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341807202022Aggressive Cyclin D1 Negative Blastoid Variant Mantle Cell Lymphoma-A Case Report.0
356804252022Cervical lymph nodes and ovarian teratomas as germinal centres in NMDA receptor-antibody encephalitis.0
354951112022Integrating whole genome sequencing, methylation, gene expression, topological associated domain information in regulatory mutation prediction: A study of follicular lymphoma.0
354447742022TdT Positive Lymphoma with MYC, BCL2 and BCL6 Rearrangements: A Review of Diagnosis and Treatment.0
354148392022Primary ovarian Burkitt lymphoma: report of a case and review of literature.0
354015092022Interacting Effects of Sea Louse (Lepeophtheirus salmonis) Infection and Formalin-Killed Aeromonas salmonicida on Atlantic Salmon Skin Transcriptome.0
353559902022Antigen-Presenting B Cells Program the Efferent Lymph T Helper Cell Response.0
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350199472022T-independent antigen induces humoral memory through germinal centers.1
347741292022Structural basis of Apt48 inhibition of the BCL6 BTB domain.0
347070342022Clinicopathological analysis of diffuse large B-cell lymphoma lacking surface immunoglobulin light chain restriction on flow cytometry.0
353713312022Clinical relevance of serum-derived exosomal messenger RNA sequencing in patients with non-Hodgkin lymphoma.0
353087232022Conjunctival Pediatric-Type Follicular Lymphoma in a Young Male: A Case Report and Literature Review.0
351947342022Mesenchymal Stem Cell-Derived Extracellular Vesicle-Shuttled microRNA-302d-3p Represses Inflammation and Cardiac Remodeling Following Acute Myocardial Infarction.1
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351251782022Predicting implantation failure: to BCL6 or not to BCL6.0
350905812022Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers.3
350813722022Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells.1
350393302022Defective STAT5 Activation and Aberrant Expression of BCL6 in Naive CD4 T Cells Enhances Follicular Th Cell-like Differentiation in Patients with Granulomatosis with Polyangiitis.0
348099782022B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population.0
346371462022EBV+ high-grade B cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a multi-institutional study.0
323930462022The expression of microRNAs and exposure to environmental contaminants related to human health: a review.7
357146152022A diminished immune response underlies age-related SARS-CoV-2 pathologies.0
357135022022TOX promotes follicular helper T cell differentiation in patients with primary Sjögren's syndrome.0
357052742022Biclonal diffuse large B-cell lymphoma commonly characterized by partial trisomy 18q involving MALT1 and BCL2.0
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356572912022Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors.0
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356526222022High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: Biopsy analysis of 70 cases from the Slovak Lymphoma Registry.0
352975662022Clinicopathological analysis of follicular lymphoma with BCL2, BCL6, and MYC rearrangements.0
350915462022Pharmacological targeting PIKfyve and tubulin as an effective treatment strategy for double-hit lymphoma.0
350871342022Copy number alterations analysis of primary tumor tissue and circulating tumor cells from patients with early-stage triple negative breast cancer.0
350501622022Altered Germinal-Center Metabolism in B Cells in Autoimmunity.0
348872472022Imaging Features with Histopathologic Correlation of CNS High-Grade Neuroepithelial Tumors with a BCOR Internal Tandem Duplication.1
347925302022Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4+ T cells.1
346015042022Histopathologic, immunophenotypic, and mutational landscape of follicular lymphomas with plasmacytic differentiation.1
329658362022Primitive Neuroectodermal Tumor0
356967852022Double-drug loading upconversion nanoparticles for monitoring and therapy of a MYC/BCL6-positive double-hit diffuse large B-cell lymphoma.0
355868952022RNAseq identification of FISH-cryptic BCL6::TP63 rearrangement in ALK-negative anaplastic large-cell lymphoma.0
355771512022Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine.0
355227222022Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis.0
355116912022A Combined Biomarker of Bright CD38 and MYC ≥55% Is Highly Predictive of Double-/Triple-Hit High-Grade B-Cell Lymphoma.0
355037212022The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress.0
354990812022Labile iron accumulation augments T follicular helper cell differentiation.0
351123552022Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T-follicular helper cells and germinal center B cells.0
349079962022Human Germinal Center-associated Lymphoma (HGAL) Is a Reliable Marker of Normal and Neoplastic Follicular Helper T Cells Including Angioimmunoblastic T-Cell Lymphoma.0
348420192022Fitting double-hit lymphoma into the aggressive lymphoma spectrum: a square peg in a round hole?0
350081872021Low BACH2 Expression Predicts Adverse Outcome in Chronic Lymphocytic Leukaemia.0
350043202021Case Report: Phenotypic Switch in High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements: A Potential Mechanism of Therapeutic Resistance in Lymphoma?0
349824542021The potential mechanism of PPP2R3A in myocardial cells and its interacting proteins.0
349501302021The Chemokine Receptor CCR5 Links Memory CD4+ T Cell Metabolism to T Cell Antigen Receptor Nanoclustering.0
349481122021The Framework for Human Host Immune Responses to Four Types of Parasitic Infections and Relevant Key JAK/STAT Signaling.1
349450042021Artificial Neural Networks Predicted the Overall Survival and Molecular Subtypes of Diffuse Large B-Cell Lymphoma Using a Pancancer Immune-Oncology Panel.1
349449542021Impact of a Faulty Germinal Center Reaction on the Pathogenesis of Primary Diffuse Large B Cell Lymphoma of the Central Nervous System.0
349003542021Rare Presentation of Hypoglycemia in a Patient with Anaplastic Large-Cell Lymphoma.0
348468842021Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket.0
348196702021FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.4
347267302021The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.0
347193212021Analysis of immune-related key genes in Alzheimer's disease.1
344499782021Angioimmunoblastic T-cell lymphoma diagnosed from pleural fluid by integration of morphologic, immunophenotypic, and molecular findings.0


Pubmed IDLast YearTitleAuthors
125550642003Ambivalent role of BCL6 in cell survival and transformation.Albagli-Curiel O et al
115161112001Detection of translocations affecting the BCL6 locus in B cell non-Hodgkin's lymphoma by interphase fluorescence in situ hybridization.Sanchez-Izquierdo D et al
33151791987Initial and subsequent cytogenetic studies in malignant lymphoma.Sanger WG et al


Jean-Loup Huret

t(3;6)(q27;q15) ?/BCL6

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/haematological/1626/t(3;6)(q27;q15)

External Links