1.Kuwait Cancer Control Center, Department of Hematology annaadria@yahoo.com
Unbalanced whole-arm chromosome translocations (WAT) involving the long arm of chromosome 1 are relatively rare anomalies in hematologic malignancies. They may involve acrocentric chromosomes (e.g der(15)t(1;15)(q10;p10), der(21)t(1;21)(q10;p13) and der(22)t(1;22)(q10;p10) ) or telomeric regions of nonacrocentric chromosomes (e.g der(12)t(1;12) (q10;q24.3) and der(19)t(1;19)(q10;q13.4). The most common WAT of 1q to centromeric or pericentromeric regions of other recipient chromosomes (indicated as p10 or q10;p10 or q10) are the der(1;7), der(1;13), der(16)t(1;16) and der(19)t(1;19) that are non-randomly distributed among hematological malignancies. The derivatives of these translocations have been shown to give rise to a dicentric chromosome in a few cases (Sawyer et al., 1998; Fogu et al 2012).
Sex/Age
Disease
Karyotype
1.
M/49
CML
48,XY,+8,t(9;22),der(10)t(1;10)(q11;p12)
2.
M
MM
46,XY,del(5)(q13q22),der(10)t(1;10)(q11;p11),t(11;14)(q13;q32),der(14)t(11;14)/46,XY,del(5),t(11;14),der(12) t(1;12)(q11;p11),der(14)t(11;14)
3.
M/ 36
MDS
46,XY,+1,dic(1;10)(p11;p11)
4.
61/M
46,XY,+1,der(1;10)(q10;p10)
5.
1/F
AML
46,XX,t(8;16)(p11;p13)/46,idem,der(10)t(1;10)(q11;p11)/46,idem,add(7)(p21)/46,idem,add(7),der(10)
Soad Al Bahar ; Adriana Zamecnikova
Unbalanced whole-arm translocation der(1;10)(q10-q11;p10-p12)
Atlas Genet Cytogenet Oncol Haematol. 2015-11-01
Online version: http://atlasgeneticsoncology.org/haematological/1650/unbalanced-whole-arm-translocation-der(1;10)(q10-q11;p10-p12)