t(1;5)(p32;q31) without TAL1 rearrangement

2017-04-01   Adriana Zamecnikova 

1.Kuwait Cancer Control Center, Department of Hematology, Laboratory of Cancer Genetics, Kuwait; annaadria@yahoo.com


1p32 translocations and submicroscopic interstitial deletions resulting in TAL1 deregulation are known aberrations in T lymphoblastic leukemia/lymphoma. The t(1;5)(p32;q31) is a rare translocation of 1p32 described only in 1 patient with aberrantly expressed TAL1 mRNA and protein (François et al., 1998) and in 2 other patients without involvement of the TAL1 gene.

Clinics and Pathology


Acute lymphocytic leukaemia (ALL) and acute promyelocytic leukemia (APL)


Only 2 ALL cases reported: a 49-years old male with T-cell ALL (Cho et al., 2009) and a 10-years old male diagnosed with B-ALL (Kaleem et al., 2000). In addition, a t(1;5)(p32;q31) was detected as an additional anomaly in a 29-years old female patient diagnosed with acute promyelocyte leukemia (Zamecnikova, unpublished case).


Yet poorly known; the pediatric case with B-precursor phenotype achieved complete remission after induction chemotherapy and remains in complete continuous remission for 24 months (Kaleem et al., 2000). Induction chemotherapy failed to induce remission in the adult patient with T-ALL and 5 months later the patient died due to renal failure and metabolic acidosis (Cho et al., 2009). In the APL case, induction was started with ATRA based therapy resulting in complete remission and she remains in complete remission for 14+ months.


Atlas Image
Figure 1. Partial karyotypes with t(1;5)(p32;q31).

Cytogenetics morphological

May be overlooked in suboptimal preparations.
Atlas Image
Figure 2. (A) Fluorescence in situ hybridization with LSI CSF1R (SpectrumOrange)/D5S23, D5S721 (SpectrumGreen) showing the presence of 5q sequences on der(1) chromosome. (B) Hybridization with Vysis LSI 1p36 (SpectrumOrange) / LSI 1q25 (SpectrumGreen) probes showing translocation of 1p sequences to der(5) chromosome.


LSI CSF1R (SpectrumOrange/D5S23, D5S721 SpectrumGreen, and Vysis LSI 1p36 (SpectrumOrange) / LSI 1q25 (SpectrumGreen) probes.

Additional anomalies

Secondary anomaly in addition to t(8;14)(q11.2;q32) in a pediatic B-ALL patient (Kaleem et al., 2000), associated with del(6q) in a sideline in the T-ALL case (Cho et al., 2009) and found in association witht(15;17)(q24;q21) in the APL case.

Result of the Chromosomal Anomaly


Because of its rarity, the role of t(1;5)(p32;q31) in disease pathogenesis as well as its clinical significance is unclear. Unlike in the T-ALL case described by François et al., 1998, neither TAL1 translocation nor its aberrant expression was detected FISH and by immunohistochemical staining in the other T-ALL patient (Cho et al., 2009). Therefore it is likely that some other genes located at 1p32 such as BLYM, EPS15, CDKN2C, and JUN may be involved in leukemogenesis (Cho et al., 2009). In the remaining 2 cases, t(1;5)(p32;q31) was found in addition to t(8;14)(q11.2;q32) and to t(15;17)(q24;q21) likely representing a secondary event in these cases.


Pubmed IDLast YearTitleAuthors
195716162009A novel translocation t(1;5)(p32;q31) that was not associated with the TAL1 rearrangement in a case of T lymphoblastic leukemia/lymphoma.Cho HS et al
97139951998Deregulated expression of the TAL1 gene by t(1;5)(p32;31) in patient with T-cell acute lymphoblastic leukemia.François S et al
106737392000Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group Study.Kaleem Z et al


Adriana Zamecnikova

t(1;5)(p32;q31) without TAL1 rearrangement

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/haematological/1787/t(1;5)(p32;q31)