t(11;14)(q11;q32)

2017-11-01   Adriana Zamecnikova 

1.Kuwait Cancer Control Center, Kuwait annaadria@yahoo.com

Abstract

Review on t(11;14)(q11;q32), with data on clinics, and the genes involved.

Clinics and Pathology

Disease

B-cell lymphoid malignancies and multiple myeloma.

Etiology

B-cell lymphoid malignancies in 5: 3 chronic lymphocytic leukemia (CLL) (Schroder et al., 1981; Weisenburger et al., 1987; Bird et al., 1989), 1 plasma cell leukemia (PCL) (Ueshima et al., 1983), 1 mantle cell lymphoma (MCL) (Espinet et al., 1999) and 2 multiple myeloma (MM) patients (Sawyer et al., 1995; Gozzetti et al., 2011).

Epidemiology

2 males and 5 females aged 45 to 78 years, median 63 years.

Prognosis

Chromosome 14q32 translocations that are part of complex karyotypes are associated with an adverse prognosis in B-cell malignancies.

Genes Involved and Proteins

Gene name
IGH (Immunoglobulin Heavy Locus)
Location
14q32.33
Note
IGH translocations relocate genes near active regulatory sequences of the partner gene, resulting in their overexpression.

Result of the Chromosomal Anomaly

Oncogenesis

Translocations involving chromosome 14 at band q32, at the site of the immunoglobulin heavy chain (IGH) locus have been described in a spectrum of B-cell malignancies. In these translocations, various partner chromosomes have been described, including chromosome 11, of which the t(11;14)(q13;q32) that leads to the overexpression of the CCND1 gene is the most common. Chromosome translocations involving centromeric 11q breakpoints are less frequent and have been described only in sporadic cases of B-cell lymphoid malignancies and multiple myeloma. Although the mechanism of neoplastic transformation remains unknown, deregulation of the translocated partner gene as a consequence of its transposition into the IGH locus may represent a mechanism of oncogene activation.

Bibliography

Pubmed IDLast YearTitleAuthors
29187551989Chromosome abnormalities in B cell chronic lymphocytic leukemia and their clinical correlations.Bird ML et al
103265981999Translocation (11;14)(q13;q32) and preferential involvement of chromosomes 1, 2, 9, 13, and 17 in mantle cell lymphoma.Espinet B et al
217678772011A central nervous system CD56 positive multiple myeloma patient with a t(11;14) (q11;q32): a case report.Gozzetti A et al
76279331995Cytogenetic findings in 200 patients with multiple myeloma.Sawyer JR et al
69745901981Chromosome changes in human chronic lymphocytic leukemia.Schröder J et al
64012251983Cytogenetic studies and clinical aspects of patients with plasma cell leukemia and leukemic macroglobulinemia.Ueshima Y et al
35556481987Intermediate lymphocytic lymphoma: immunophenotypic and cytogenetic findings.Weisenburger DD et al

Summary

Fusion gene

?/IGH

Citation

Adriana Zamecnikova

t(11;14)(q11;q32)

Atlas Genet Cytogenet Oncol Haematol. 2017-11-01

Online version: http://atlasgeneticsoncology.org/haematological/1806/t(11;14)(q11;q32)

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