t(11;14)(p11;q32)

2002-01-01   Antonio Cuneo 

1.Hematology Section, Dept. Of Biomedical Sciences, University of Ferrara, 44100 Ferrara Italy

Clinics and Pathology

Phenotype stem cell origin

CD19+; CD5-; CD22+; CD23-; CD10-; CD25-/+; CD38+; CD11c-; CD103-; FMC7+; surface Ig bright+. The transformed cell represents an IgM+/IgD+ B-lymphocyte deriving from the marginal zone.

Epidemiology

The translocation is rare (<1% of B-cell chronic lymphoid neoplasias)

Clinics

These patients may feature a relatively aggressive clinical course as compared with other cases of splenic MZBCL

Cytology

Usually, the abnormal lymphocytes in the PB smear are morphologically heterogeneous. The majority of cells are >14 mm in size, with pleomorphism of nuclear shapes, fine chromatin structure and distinct nucleoli. Some lymphocytes with short villi may be present along with larger lymphoid cells and rare prolymphocyte-like cells.

Pathology

The bone biopsy may show B-lymphoid cells of intermediate size with an interstitial infiltration pattern. An intrasinusoidal pattern of growth was also noted.
The spleen specimens display a nodular lymphoid infiltrate of the white pulp by small lymphocytes mixed with larger blast cells with clear cytoplasm, centered on polyclonal follicle centers. Red pulp involvement may occur.

Treatment

The patients may show partial responses to alkylating agent and to multiagenet chemotherapy.

Evolution

Transformation into high-grade lymphoma was reported.

Cytogenetics

Cytogenetics morphological

The tranlocation was described as a balanced t(11;14)(p11;q32).

Cytogenetics molecular

To detect the 14q32 break, the cos-Ca1, cosIg6 and cos3/64 and YAC Y6 were used. Splitting of cosmid signals and Y6 signals has been detected, indicating a break downstream of the IgVH sequences, in the region flanked by cos3/64 and Y6. The gene involved at the 11p11 band is presently unknown.

Additional anomalies

del(7)(q22q32); +12; del(17)(p12). In one case a 7q- chromosome was the primary anomaly, the t(11;14) having found at the time of histologic transformation into high grade lymphoma

Bibliography

Pubmed IDLast YearTitleAuthors
68506081983Nonrandom chromosome abnormalities in lymphoma.Bloomfield CD et al
114805692001A novel recurrent translocation t(11;14)(p11;q32) in splenic marginal zone B cell lymphoma.Cuneo A et al

Citation

Antonio Cuneo

t(11;14)(p11;q32)

Atlas Genet Cytogenet Oncol Haematol. 2002-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2116/t(11;14)(p11;q32)

External Links