t(X;7)(q22;q34) TRB/IRS4

2018-01-01   Jean-Loup Huret  , Philippe Dessen  

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes Involved and Proteins

Gene name
TRB
Location
7q34
Gene name
IRS4
Location
Xq22.3

Article Bibliography

Pubmed IDLast YearTitleAuthors
190556612009The t(X;7)(q22;q34) in paediatric T-cell acute lymphoblastic leukaemia results in overexpression of the insulin receptor substrate 4 gene through illegitimate recombination with the T-cell receptor beta locus.Karrman K et al

Summary

Fusion gene

TRB/IRS4 TRB (7q34) IRS4 (Xq22.3)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Jean-Loup Huret ; Philippe Dessen

t(X;7)(q22;q34) TRB/IRS4

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/3288/t(x