(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)
Note
Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute
Summary
Note
Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to How to contribute
if you are an author who wish to write a full paper/card on this translocation,go to How to contribute
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31934854 | 2020 | The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer. | 88 |
| 35751785 | 2022 | Genomic and transcriptomic analysis of Korean colorectal cancer patients. | 43 |
| 28695896 | 2017 | R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine. | 42 |
| 35715628 | 2022 | Clinicopathological and molecular characteristics of RSPO fusion-positive colorectal cancer. | 41 |
| 29181107 | 2017 | Investigation of fusion gene expression in HCT116 cells. | 31 |
| 36129915 | 2022 | Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer. | 30 |
| 32217638 | 2020 | Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles. | 0 |
| 26700806 | 2016 | Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function. | 0 |
| 26924569 | 2016 | Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma. | 0 |
| 28543708 | 2017 | Comprehensive characterization of RSPO fusions in colorectal traditional serrated adenomas. | 0 |
| 30916365 | 2019 | EIF3E-RSPO2 and PIEZO1-RSPO2 fusions in colorectal traditional serrated adenoma. | 0 |
| 24847761 | 2014 | RSPO fusion transcripts in colorectal cancer in Japanese population. | 0 |
| 30179900 | 2019 | Acquisition of WNT Pathway Gene Alterations Coincides With the Transition From Precursor Polyps to Traditional Serrated Adenomas. | 0 |
| 35449312 | 2022 | Comprehensive genetic characterization of rectal cancer in a large cohort of Japanese patients: differences according to tumor location. | 0 |
| 37022622 | 2023 | Incidence and clinical significance of 491 known fusion genes in a large cohort of Japanese patients with colorectal cancer. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 22895193 | 2012 | Recurrent R-spondin fusions in colon cancer. | Seshagiri S et al |
| 24847761 | 2014 | RSPO fusion transcripts in colorectal cancer in Japanese population. | Shinmura K et al |
Citation
Jean-Loup Huret ; Philippe Dessen
PTPRK/RSPO3 (6q22)
Atlas Genet Cytogenet Oncol Haematol. 0000-00-00
Online version: http://atlasgeneticsoncology.org/solid-tumor/107252/ptprk-rspo3-(6q22)
