Benign and preinvasive mesothelial tumors

2023-03-24 Yin (Rex) Hung, MD Affiliation

1.Massachusetts General Hospital and Harvard Medical School, Boston

Benign and pre-invasive mesothelial tumors include adenomatoid tumor, well-differentiated papillary mesothelial tumor, and mesothelioma in situ.

Benign and preinvasive mesothelial tumors	Genetic marker(s)
Adenomatoid tumor of the pleura	Somatic missense mutations involving TRAF7 in >80% of cases. No mutations typical of mesothelioma such as BAP1, SETD2, NF2, PBRM1, and others.¹
Well-differentiated papillary mesothelial tumor of the pleura	Somatic missense mutations in TRAF7 or CDC42, which appear mutually exclusive of one another, have been reported in some cases. Mutations in EHD1, ATM, FBXO10, SH2D2A, CDH5, MAGED1, and TP73 have also been reported. No evidence of other typical mutations seen in mesothelioma such as BAP1, SETD2, NF2, PBRM1, and others.^2,3
Mesothelioma in situ	Some cases harbor somatic BAP1 mutations, otherwise no other alterations as detected by whole-exome sequencing. In addition to BAP1 alterations, loss of MTAP expression has been noted in rare cases.^4,5

Reference Number	Pubmed ID	Last Year	Title	Authors
1	29148537	2018	Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation.	Goode B et al
2	30171198	2019	Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.	Stevers M et al
3	32545767	2020	Well-Differentiated Papillary Mesothelioma of the Peritoneum Is Genetically Distinct from Malignant Mesothelioma.	Shrestha R et al
4	31375770	2020	Malignant mesothelioma in situ: morphologic features and clinical outcome.	Churg A et al
5	32932212	2020	Whole exome sequencing reveals BAP1 somatic abnormalities in mesothelioma in situ.	Dacic S et al

Yin (Rex) Hung, MD

Benign and preinvasive mesothelial tumors

Atlas Genet Cytogenet Oncol Haematol. 2023-03-24

Cookies