Soft Tissues: Inflammatory myofibroblastic tumor with t(2;19)(p23;p13) TPM4/ALK
2001-08-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Clinics
rare soft tissue tumour found in children and young adults
Pathology
spindle cell proliferation with myofibroblastic differenciation and an inflammatory infiltrate
Prognosis
low malignant potential and good prognosis
Genes Involved and Proteins
Gene name
ALK (anaplastic lymphoma receptor tyrosine kinase)
Location
2p23.2
Protein description
1620 amino acids; 177 kDa; glycoprotein (200 kDa mature protein) ; membrane associated tyrosine kinase receptor
Gene name
TPM4 (tropomyosin)
Location
19p13.12
Protein description
248 amino acids, 29 kDa; coiled coil structure
Result of the chromosomal anomaly
Description
5 TPM4 - 3 ALK
Description
783 amino acids. N-term TPM4 containing all but its 27 C-term amino acids , including the coiled coil domain, fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain)
Expression localisation
predominantly cytoplasmic
Oncogenesis
TPM4-ALK is contituvely activated
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 17131471 | 2006 | Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer. | 57 |
| 10934142 | 2000 | TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. | 40 |
| 25300797 | 2014 | Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma. | 32 |
| 38711893 | 2024 | Partial response to crizotinib + regorafenib + PD-1 inhibitor in a metastatic BRAF V600EMT colon cancer patient with acquired C-MET amplification and TPM4-ALK fusion: a case report. | 29 |
| 31278140 | 2019 | The effects of crizotinib in a transgenic Drosophila model expressing the human TPM4-ALK fusion gene or TPM4. | 28 |
| 29268561 | 2017 | Pulmonary inflammatory myofibroblastic tumor with TPM4-ALK translocation. | 11 |
| 35172497 | 2017 | Crizotinib Failure in a TPM4-ALK-Rearranged Inflammatory Myofibroblastic Tumor With an Emerging ALK Kinase Domain Mutation. | 0 |
| 17694547 | 2008 | Development of anaplastic lymphoma kinase (ALK) small-molecule inhibitors for cancer therapy. | 0 |
| 38266918 | 2024 | Molecular Screening in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling. | 0 |
| 32868646 | 2020 | Lorlatinib for the treatment of inflammatory myofibroblastic tumour with TPM4-ALK fusion following failure of entrectinib. | 0 |
| 15764578 | 2004 | Low-grade sarcomas with CD34-positive fibroblasts and low-grade myofibroblastic sarcomas. | 0 |
| 12787312 | 2003 | Inflammatory myofibroblastic tumor with predominant anaplastic lymphoma kinase-positive cells lacking a myofibroblastic phenotype. | 0 |
| 16984614 | 2006 | Absence of human herpesvirus-8 and Epstein-Barr virus in inflammatory myofibroblastic tumor with anaplastic large cell lymphoma kinase fusion gene. | 0 |
| 20092987 | 2010 | Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells. | 0 |
| 15080301 | 2004 | Assessment of t(2;5)(p23;q35) translocation and variants in pediatric ALK+ anaplastic large cell lymphoma. | 0 |
| 17318615 | 2007 | Proteomic profiling of proteins dysregulted in Chinese esophageal squamous cell carcinoma. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10383129 | 1999 | Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. | Griffin CA et al |
| 10934137 | 2000 | Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms. | Ladanyi M et al |
Citation
Jean-Loup Huret
Soft Tissues: Inflammatory myofibroblastic tumor with t(2;19)(p23;p13) TPM4/ALK
Atlas Genet Cytogenet Oncol Haematol. 2001-08-01
Online version: http://atlasgeneticsoncology.org/solid-tumor/5128/soft-tissues-inflammatory-myofibroblastic-tumor-with-t(2
