1.Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
Bone tumors are mostly of mesenchymal origin, though for example Ewing sarcoma is thought to have neuroectodermal precursor cells. Classification of the World Health Organization will be followed in this overview. Grading of bone tumors is roughly based on the cellularity of the lesion compared to the amount of extracellulair matrix, nuclear features, the presence of mitotic figures and necrosis. Staging via the TNM system is normally not used, because metastases in lymph nodes are not frequent in these lesions. Therefore staging is based on degree of differentiation of the tumor tissue and local and distant spread of the tumor.
Genetic information and references are provided for tumors investigated in more than a single case.
Osteogenic tumors
Fibrogenic tumors
Fibrohistiocytic tumors
Ewing sarcoma/Primitive neuroectodermal tumor
Giant cell tumors
Notochordal tumors
Vascular tumors
Myogenic, lipogenic, neural and epithelial tumors
Tumors of undefined neoplastic nature
Yvonne M Schrage ; Judith VMG Bovée
Bone tumors: an overview
Atlas Genet Cytogenet Oncol Haematol. 2005-03-01
Online version: http://atlasgeneticsoncology.org/solid-tumor/5143/case-report-explorer/deep-insight-explorer/css/template-card.css