Soft Tissues: Inflammatory myofibroblastic tumor with t(2;11)(p23;p15) CARS/ALK
2003-08-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Clinics
rare soft tissue tumour found in children and young adults
Pathology
spindle cell proliferation with myofibroblastic differenciation and an inflammatory infiltrate
Cytogenetics
The translocation was found complex: t(2;11;2)(p23;p15;q31)
Prognosis
low malignant potential and good prognosis
Genes Involved and Proteins
Gene name
ALK (anaplastic lymphoma receptor tyrosine kinase)
Location
2p23.2
Protein description
1620 amino acids; 177 kDa; glycoprotein (200 kDa mature protein) ; membrane associated tyrosine kinase receptor
Gene name
CARS (cysteinyj-tRNA synthetase)
Location
11p15.4
Protein description
748 amino acids, 85 kDa. Forms homodimers
Result of the chromosomal anomaly
Description
5 CARS - 3 ALK
Description
606 N-term amino acid from CARS, fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain).
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32997436 | 2021 | Metastatic Low-Grade Sarcoma with CARS-ALK Fusion Dramatically Responded to Multiple ALK Tyrosine Kinase Inhibitors: A Case Report with Comprehensive Genomic Analysis. | 16 |
| 36648781 | 2023 | Epithelioid Fibrous Histiocytoma with CARS-ALK Fusion: First Case Report. | 14 |
| 35560368 | 2022 | Cutaneous inflammatory myofibroblastic tumor with CARS-ALK fusion: Case report and literature review. | 0 |
| 13679433 | 2003 | Identification of CARS-ALK fusion in primary and metastatic lesions of an inflammatory myofibroblastic tumor. | 0 |
| 34001695 | 2021 | Clinicopathologic and Genomic Characterization of Inflammatory Myofibroblastic Tumors of the Head and Neck: Highlighting a Novel Fusion and Potential Diagnostic Pitfall. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 12112524 | 2002 | Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor. | Cools J et al |
| 10383129 | 1999 | Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. | Griffin CA et al |
| 10934137 | 2000 | Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms. | Ladanyi M et al |
| 12661011 | 2003 | Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor. | Ma Z et al |
Citation
Jean-Loup Huret
Soft Tissues: Inflammatory myofibroblastic tumor with t(2;11)(p23;p15) CARS/ALK
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/solid-tumor/5213/soft-tissues-inflammatory-myofibroblastic-tumor-with-t(2
