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t(3;3)(q27;q28) EIF4A2/BCL6

Written2009-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2090

Clinics and Pathology

Disease Non Hodgkin lymphoma.
Epidemiology One case of follicular lymphoma transformed to diffuse aggressive lymphoma, from a study with no individual data (Akasaka et al., 2003).

Genes involved and Proteins

Gene Name EIF4A2
Location 3q28
Protein RNA helicase ATP-dependent; subunit of the eIF4F complex involved in translation control.
Gene Name BCL6
Location 3q27
Protein 706 amino acids; composed of a NH2-term BTB/POZ domain (amino acids 1-130 (32-99 according to Swiss-Prot) which mediates homodimerization and protein-protein interactions with other corepressors (including HDAC1 and NCOR2/SMRT ) to constitute a large repressing complex, another transcription repression domain (191-386), PEST sequences (300-417) with a KKYK motif (375-379), and six zinc finger at the C-term (518-541, 546-568, 574-596, 602-624, 630-652, 658-681), responsible for sequence specific DNA binding. Transcription repressor; recognizes the consensus sequence: TTCCT(A/C)GAA (Albagli-Curiel, 2003).

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma.
Akasaka T, Lossos IS, Levy R.
Blood. 2003 Aug 15;102(4):1443-8. Epub 2003 May 8.
PMID 12738680
 
Ambivalent role of BCL6 in cell survival and transformation.
Albagli-Curiel O.
Oncogene. 2003 Jan 30;22(4):507-16.
PMID 12555064
 

Citation

This paper should be referenced as such :
Huret, JL
t(3;3)(q27;q28)
Atlas Genet Cytogenet Oncol Haematol. 2010;14(1):72-72.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0303q27q28ID2090.html


Other genes implicated (Data extracted from papers in the Atlas) [ 2 ]

Genes BCL6 EIF4A2

Translocations implicated (Data extracted from papers in the Atlas)

 t(3;3)(q27;q28) EIF4A2/BCL6

External links

arrayMap (UZH-SIB Zurich)EIF4A2 (3q27.3) BCL6 (3q27.3)

Mitelman databaset(3;3)(q27;q28) [Case List]    t(3;3)(q27;q28) [Association List] Mitelman database (CGAP - NCBI)
arrayMap[select an item]
 
Mitelman databaseEIF4A2/BCL6 [MCList]  EIF4A2 (3q27.3) BCL6 (3q27.3)
 
Disease databaset(3;3)(q27;q28) EIF4A2/BCL6
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Mar 14 13:54:32 CET 2017


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