t(6;22)(p21;q11)
2010-06-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Hematological malignancies.
Note
So far, the t(6;22)(p21;q11) is heterogeneous, and its significance remains problematic.
Phenotype stem cell origin
Four cases availble: one case was a myeloid type blast crisis of chronic myeloid leukemia (CML) in a 36-year-old male patient with a t(9;22)(q34;q11); another case was a CML aberrant translocation t(6;22)(p21;q11) without apparent involvement of chromosome 9 in a 44-year-old male patient; a third case was that of a B-cell precursor (CD10+) L1- acute lymphoblastic leukemia in a 2-year-old girl who was still in complete remission 72 months after diagnosis. A cryptic 5 ETV6 - 3 RUNX1 was found; there were accompanying anomalies, of which a +10 and a +21; the last case was a chronic lymphocytic leukemia (CLL) stage C with also a del(11q), and a del(13q).
Genes Involved and Proteins
Note
Genes involved, if any, are unknown.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8913730 | 1996 | Correlation between the ETV6/CBFA2 (TEL/AML1) fusion gene and karyotypic abnormalities in children with B-cell precursor acute lymphoblastic leukemia. | Fears S et al |
| 3855371 | 1985 | Philadelphia chromosome (Ph) positive chronic myelocytic leukemia (CML): frequency of additional findings. | Gödde-Salz E et al |
| 16179374 | 2006 | Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia. | Mayr C et al |
| 15350303 | 2004 | Effect of interferon-alpha on chromosome abnormalities in treated chronic myelogenous leukemia patients. | Tanaka H et al |
Summary
t(6;22)(p21;q11) G-banding and FISH - Courtesy Claudia Haferlach.
Citation
Jean-Loup Huret
t(6;22)(p21;q11)
Atlas Genet Cytogenet Oncol Haematol. 2010-06-01
Online version: http://atlasgeneticsoncology.org/haematological/1563/t(6;22)(p21;q11)
