Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(6;22)(p21;q11)
| Identity |
 | |
| t(6;22)(p21;q11) G-banding and FISH - Courtesy Claudia Haferlach. | |
| Clinics and Pathology |
| Disease | Hematological malignancies. |
| Note | So far, the t(6;22)(p21;q11) is heterogeneous, and its significance remains problematic. |
| Phenotype / cell stem origin | Four cases availble: one case was a myeloid type blast crisis of chronic myeloid leukemia (CML) in a 36-year-old male patient with a t(9;22)(q34;q11); another case was a CML aberrant translocation t(6;22)(p21;q11) without apparent involvement of chromosome 9 in a 44-year-old male patient; a third case was that of a B-cell precursor (CD10+) L1- acute lymphoblastic leukemia in a 2-year-old girl who was still in complete remission 72 months after diagnosis. A cryptic 5' ETV6 - 3' RUNX1 was found; there were accompanying anomalies, of which a +10 and a +21; the last case was a chronic lymphocytic leukemia (CLL) stage C with also a del(11q), and a del(13q). |
| Genes involved and Proteins |
| Note | Genes involved, if any, are unknown. |
| External links |
| Other database | t(6;22)(p21;q11) | Mitelman database (CGAP - NCBI) |
| To be noted |
| Additional cases are needed to delineate different entities with this anomaly: you are welcome to submit a paper to our new Case Report section. | |
| Case Report | t(6;22)(p21;q11.2) arising at second relapse in a patient with t(8;21)-positive acute myeloid leukemia |
| Bibliography |
| Philadelphia chromosome (Ph) positive chronic myelocytic leukemia (CML): frequency of additional findings. |
| Godde-Salz E, Schmitz N, Bruhn HD. |
| Cancer Genet Cytogenet. 1985 Jan 15;14(3-4):313-22. |
| PMID 3855371 |
| Correlation between the ETV6/CBFA2 (TEL/AML1) fusion gene and karyotypic abnormalities in children with B-cell precursor acute lymphoblastic leukemia. |
| Fears S, Vignon C, Bohlander SK, Smith S, Rowley JD, Nucifora G. |
| Genes Chromosomes Cancer. 1996 Oct;17(2):127-35. |
| PMID 8913730 |
| Effect of interferon-alpha on chromosome abnormalities in treated chronic myelogenous leukemia patients. |
| Tanaka H, Tanaka K, Oguma N, Ito K, Ito T, Kyo T, Dohy H, Kimura A. |
| Cancer Genet Cytogenet. 2004 Sep;153(2):133-43. |
| PMID 15350303 |
| Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia. |
| Mayr C, Speicher MR, Kofler DM, Buhmann R, Strehl J, Busch R, Hallek M, Wendtner CM. |
| Blood. 2006 Jan 15;107(2):742-51. |
| PMID 16179374 |
| Contributor(s) |
| Written | 06-2010 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(6;22)(p21;q11). Atlas Genet Cytogenet Oncol Haematol. June 2010 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0622p21q11ID1563.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/2042/44988/1/06-2010-t0622p21q11ID1563.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Mar 9 12:37:23 CET 2013 |
For comments and suggestions or contributions, please contact us