t(8;14)(q11;q32)

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t(8;14)(q11;q32)

Identity

- 8, + der(14) t(8;14)(q11;q32) G banding (left) - Courtesy Gitte Birk Kerndrup and Steen Rosthoj; der(14) t(8;14)(q11;q32) R-banding -Courtesy Pascale Cornillet-Lefebvre and Stéphanie Struski (top) , and with a constitutional trisomy 21 (bottom) - Courtesy Petr Balicek , Jana Rabasova, and Jiri Hak. More iconography can be found in the Case Report section (see below).

Clinics and Pathology

Disease CD10+ acute lymphoblastic leukemia (ALL) in most cases; chronic myelogenous leukemia (CML) very rarely; one case of histiocyte-rich B-cell lymphoma

Etiology Strikingly, 1/4 of cases are Down syndrome patients.

Epidemiology More than 40 cases are known now; represents about 1/1 000 cases of childhood leukemias; median age is 11 yrs (range 4-48), with 10% above 20 yrs; unbalanced sex ratio (2M/1F)

Clinics Organomegaly is not frequent, central nervous system (CNS) involvement was not noted; WBC was < 50 X 10⁹/l in most cases

Prognosis Still to be studied (you are welcome to send us recent data on your published - or unpublished- cases); probably not bad; a Kaplan-Meier from 22 (heterogenous) cases would show that 2/3 of patients survive; however, only half cases reach a 2 yrs follow up (row data are: 1, 5+, 6+, 7, 8+, 9, 9+, 10+, 11+, 23, 24+, 30+, 31, 32, 36+, 51+, 98+, 99+, 108+, 111+, 112+, and 123+).

Cytogenetics

Cytogenetics Morphological Sole (acquired) anomaly in 1/4 of cases; accompany a t(9;22)(q34;q11) in 20% of cases; unbalanced form with a der(14) t(8;14) in 20% of cases, indicating that the crucial event is likely to lie on der(14).

Additional anomalies t(8;14) may be found with t(9;22) (see above); t(8;14) is accompanied by an acquired (not constitutional) +21 in 10% of cases; +X, +8, and del(13q) are also recurrently found with t(8;14).

Genes involved and Proteins

Note The gene involved in 8q11 is unknown; the gene involved in 14q32 is IgH, found rearranged in cases where it was tested

External links

Other database t(8;14)(q11;q32) Mitelman database (CGAP - NCBI)

Other database t(8;14)(q11;q32) CancerChromosomes (NCBI)

Other database	t(8;14)(q11;q32)	Mitelman database (CGAP - NCBI)
Other database	t(8;14)(q11;q32)	CancerChromosomes (NCBI)

To be noted

Case Report A case of pre-B ALL with t(8;14)(q11;q32)

Case Report A case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32)

Case Report A new case of t(8;14)(q11;q32) in an acute lymphoblastic leukemia

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A case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32).

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A case of pre-B ALL with t(8;14)(q11;q32).

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Three further cases of t(8;14)(q11.2;q32) in acute lymphoblastic leukemia.

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Contributor(s)

Written 11-1999 Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL . t(8;14)(q11;q32). Atlas Genet Cytogenet Oncol Haematol. November 1999 .
URL : http://AtlasGeneticsOncology.org/Anomalies/t0814ID1112.html

Huret JL . t(8;14)(q11;q32). Atlas Genet Cytogenet Oncol Haematol. .
URL : http://AtlasGeneticsOncology.org/Anomalies/t0814ID1112.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon May 12 18:12:40 2008

Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

For comments and suggestions or contributions, please contact us

j.l.huret@chu-poitiers.fr.

Disease	CD10+ acute lymphoblastic leukemia (ALL) in most cases; chronic myelogenous leukemia (CML) very rarely; one case of histiocyte-rich B-cell lymphoma
Etiology	Strikingly, 1/4 of cases are Down syndrome patients.
Epidemiology	More than 40 cases are known now; represents about 1/1 000 cases of childhood leukemias; median age is 11 yrs (range 4-48), with 10% above 20 yrs; unbalanced sex ratio (2M/1F)
Clinics	Organomegaly is not frequent, central nervous system (CNS) involvement was not noted; WBC was < 50 X 10⁹/l in most cases
Prognosis	Still to be studied (you are welcome to send us recent data on your published - or unpublished- cases); probably not bad; a Kaplan-Meier from 22 (heterogenous) cases would show that 2/3 of patients survive; however, only half cases reach a 2 yrs follow up (row data are: 1, 5+, 6+, 7, 8+, 9, 9+, 10+, 11+, 23, 24+, 30+, 31, 32, 36+, 51+, 98+, 99+, 108+, 111+, 112+, and 123+).

Cytogenetics Morphological	Sole (acquired) anomaly in 1/4 of cases; accompany a t(9;22)(q34;q11) in 20% of cases; unbalanced form with a der(14) t(8;14) in 20% of cases, indicating that the crucial event is likely to lie on der(14).
Additional anomalies	t(8;14) may be found with t(9;22) (see above); t(8;14) is accompanied by an acquired (not constitutional) +21 in 10% of cases; +X, +8, and del(13q) are also recurrently found with t(8;14).


Case Report	A case of pre-B ALL with t(8;14)(q11;q32)
Case Report	A case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32)
Case Report	A new case of t(8;14)(q11;q32) in an acute lymphoblastic leukemia