| Alias_names | MLLT7 |
| myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 7 |
| myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 |
| Alias_symbol (synonym) | AFX1 |
| Other alias | AFX1 (ALL1 fused gene from chromosome X, 1) |
| MLLT7 (myeloid/lymphoid leukemia translocated to, 7) |
| AFX |
| FOXO4 |
| HGNC (Hugo) |
FOXO4 |
| LocusID (NCBI) |
4303 |
| Atlas_Id |
57 |
| Location |
Xq13.1 [Link to chromosome band Xq13] |
| Location_base_pair |
Starts at 71096149 and ends at 71103534 bp from pter ( according to hg19-Feb_2009) [Mapping FOXO4.png] |
| |  |
| |
| | Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics |
| |
| Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23). |
| Borkhardt A, Repp R, Haas OA, Leis T, Harbott J, Kreuder J, Hammermann J, Henn T, Lampert F |
| Oncogene. 1997 ; 14 (2) : 195-202. |
| PMID 9010221 |
| |
| Direct control of the Forkhead transcription factor AFX by protein kinase B. |
| Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, Burgering BM |
| Nature. 1999 ; 398 (6728) : 630-634. |
| PMID 10217147 |
| |
| AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. |
| Medema RH, Kops GJ, Bos JL, Burgering BM |
| Nature. 2000 ; 404 (6779) : 782-787. |
| PMID 10783894 |
| |
| Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family. |
| Parry P, Wei Y, Evans G |
| Genes, chromosomes & cancer. 1994 ; 11 (2) : 79-84. |
| PMID 7529552 |
| |
| AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as candidate genes of X-linked dystonia parkinsonism. |
| Peters U, Haberhausen G, Kostrzewa M, Nolte D, Müller U |
| Human genetics. 1997 ; 100 (5-6) : 569-572. |
| PMID 9341872 |
| |
| Nomenclature |
|---|
| HGNC (Hugo) | FOXO4 7139 |
| Cards |
|---|
| Atlas | AFX1ID57 |
| Entrez_Gene (NCBI) | FOXO4 4303 forkhead box O4 |
| Aliases | AFX; AFX1; MLLT7 |
| GeneCards (Weizmann) | FOXO4 |
| Ensembl hg19 (Hinxton) | ENSG00000184481 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000184481 [Gene_View] ENSG00000184481 [Sequence] chrX:71096149-71103534 [Contig_View] FOXO4 [Vega] |
| ICGC DataPortal | ENSG00000184481 |
| TCGA cBioPortal | FOXO4 |
| AceView (NCBI) | FOXO4 |
| Genatlas (Paris) | FOXO4 |
| WikiGenes | 4303 |
| SOURCE (Princeton) | FOXO4 |
| Genetics Home Reference (NIH) | FOXO4 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | FOXO4 - chrX:71096149-71103534 + Xq13.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | FOXO4 - Xq13.1 [Description] (hg19-Feb_2009) |
| GoldenPath | FOXO4 - Xq13.1 [CytoView hg19] FOXO4 - Xq13.1 [CytoView hg38] |
| ImmunoBase | ENSG00000184481 |
| Mapping of homologs : NCBI | FOXO4 [Mapview hg19] FOXO4 [Mapview hg38] |
| OMIM | 300033 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF384029 AK300142 AW292413 BC026735 BC106761 |
| RefSeq transcript (Entrez) | NM_001170931 NM_005938 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | FOXO4 |
| Cluster EST : Unigene | Hs.584654 [ NCBI ] |
| CGAP (NCI) | Hs.584654 |
| Alternative Splicing Gallery | ENSG00000184481 |
| Gene Expression | FOXO4 [ NCBI-GEO ] FOXO4 [ EBI - ARRAY_EXPRESS ]
FOXO4 [ SEEK ] FOXO4 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | FOXO4 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 4303 |
| GTEX Portal (Tissue expression) | FOXO4 |
| Human Protein Atlas | ENSG00000184481-FOXO4 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P98177 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P98177 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P98177 |
| Splice isoforms : SwissVar | P98177 |
| PhosPhoSitePlus | P98177 |
| Domaine pattern : Prosite (Expaxy) | FORK_HEAD_2 (PS00658) FORK_HEAD_3 (PS50039) |
| Domains : Interpro (EBI) | Fork_head_dom FOXO-TAD TF_fork_head_CS_2 WH-like_DNA-bd_sf WH_DNA-bd_sf |
| Domain families : Pfam (Sanger) | Forkhead (PF00250) FOXO-TAD (PF16676) |
| Domain families : Pfam (NCBI) | pfam00250 pfam16676 |
| Domain families : Smart (EMBL) | FH (SM00339) |
| Conserved Domain (NCBI) | FOXO4 |
| DMDM Disease mutations | 4303 |
| Blocks (Seattle) | FOXO4 |
| PDB (RSDB) | 1E17 3L2C |
| PDB Europe | 1E17 3L2C |
| PDB (PDBSum) | 1E17 3L2C |
| PDB (IMB) | 1E17 3L2C |
| Structural Biology KnowledgeBase | 1E17 3L2C |
| SCOP (Structural Classification of Proteins) | 1E17 3L2C |
| CATH (Classification of proteins structures) | 1E17 3L2C |
| Superfamily | P98177 |
| Human Protein Atlas [tissue] | ENSG00000184481-FOXO4 [tissue] |
| Peptide Atlas | P98177 |
| HPRD | 02070 |
| IPI | IPI00024316 IPI00220121 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P98177 |
| IntAct (EBI) | P98177 |
| FunCoup | ENSG00000184481 |
| BioGRID | FOXO4 |
| STRING (EMBL) | FOXO4 |
| ZODIAC | FOXO4 |
| Ontologies - Pathways |
|---|
| QuickGO | P98177 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol cytosol regulation of transcription, DNA-templated transcription by RNA polymerase II cell cycle arrest mitotic G2 DNA damage checkpoint muscle organ development aging beta-catenin binding transcription factor binding transcription factor binding negative regulation of cell proliferation insulin receptor signaling pathway insulin receptor signaling pathway positive regulation of smooth muscle cell migration negative regulation of angiogenesis protein deubiquitination nuclear speck enzyme binding response to nutrient levels glucose homeostasis identical protein binding sequence-specific DNA binding sequence-specific DNA binding sequence-specific DNA binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II stem cell differentiation negative regulation of smooth muscle cell differentiation negative regulation of G0 to G1 transition positive regulation of cell cycle arrest response to water-immersion restraint stress promoter-specific chromatin binding |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol cytosol regulation of transcription, DNA-templated transcription by RNA polymerase II cell cycle arrest mitotic G2 DNA damage checkpoint muscle organ development aging beta-catenin binding transcription factor binding transcription factor binding negative regulation of cell proliferation insulin receptor signaling pathway insulin receptor signaling pathway positive regulation of smooth muscle cell migration negative regulation of angiogenesis protein deubiquitination nuclear speck enzyme binding response to nutrient levels glucose homeostasis identical protein binding sequence-specific DNA binding sequence-specific DNA binding sequence-specific DNA binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II stem cell differentiation negative regulation of smooth muscle cell differentiation negative regulation of G0 to G1 transition positive regulation of cell cycle arrest response to water-immersion restraint stress promoter-specific chromatin binding |
| Pathways : KEGG | Ras signaling pathway FoxO signaling pathway |
| REACTOME | P98177 [protein] |
| REACTOME Pathways | R-HSA-5689880 [pathway] |
| NDEx Network | FOXO4 |
| Atlas of Cancer Signalling Network | FOXO4 |
| Wikipedia pathways | FOXO4 |
| Orthology - Evolution |
|---|
| OrthoDB | 4303 |
| GeneTree (enSembl) | ENSG00000184481 |
| Phylogenetic Trees/Animal Genes : TreeFam | FOXO4 |
| HOGENOM | P98177 |
| Homologs : HomoloGene | FOXO4 |
| Homology/Alignments : Family Browser (UCSC) | FOXO4 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | CIC/FOXO4 [19q13.2/Xq13.1] [t(X;19)(q13;q13)] |
| Fusion : Mitelman | PAX3/FOXO4 [2q36.1/Xq13.1] [t(X;2)(q13;q36)] |
| Fusion : COSMIC | CIC [19q13.2] - FOXO4 [Xq13.1] [fusion_1708] [fusion_1709] [fusion_1710] [fusion_1711] |
| Fusion : COSMIC | KMT2A [11q23.3] - FOXO4 [Xq13.1] [fusion_1976] |
| Fusion : FusionGDB | 13825 13826 |
| Fusion : Fusion_Hub | AFX1--FOXO4 CIC--FOXO4 CLMP--FOXO4 FN1--FOXO4 FOXO4--CIC FOXO4--FOXO4 FOXO4--KMT2A FOXO4--MLL FOXO4--OR1F1 FOXO4--PAX3 FOXO4--VAV3 KMT2A--FOXO4 MLL--FOXO4 PAX3--FOXO4 |
| Fusion : Quiver | FOXO4 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | FOXO4 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | FOXO4 |
| dbVar | FOXO4 |
| ClinVar | FOXO4 |
| 1000_Genomes | FOXO4 |
| Exome Variant Server | FOXO4 |
| ExAC (Exome Aggregation Consortium) | ENSG00000184481 |
| GNOMAD Browser | ENSG00000184481 |
| Varsome Browser | FOXO4 |
| Genetic variants : HAPMAP | 4303 |
| Genomic Variants (DGV) | FOXO4 [DGVbeta] |
| DECIPHER | FOXO4 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | FOXO4 |
| Mutations |
|---|
| ICGC Data Portal | FOXO4 |
| TCGA Data Portal | FOXO4 |
| Broad Tumor Portal | FOXO4 |
| OASIS Portal | FOXO4 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | FOXO4 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | FOXO4 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | X-chromosome gene database |
| BioMuta | search FOXO4 |
| DgiDB (Drug Gene Interaction Database) | FOXO4 |
| DoCM (Curated mutations) | FOXO4 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | FOXO4 (select a term) |
| intoGen | FOXO4 |
| NCG5 (London) | FOXO4 |
| Cancer3D | FOXO4(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 300033 |
| Orphanet | |
| DisGeNET | FOXO4 |
| Medgen | FOXO4 |
| Genetic Testing Registry | FOXO4
|
| NextProt | P98177 [Medical] |
| TSGene | 4303 |
| GENETests | FOXO4 |
| Target Validation | FOXO4 |
| Huge Navigator |
FOXO4 [HugePedia] |
| snp3D : Map Gene to Disease | 4303 |
| BioCentury BCIQ | FOXO4 |
| ClinGen | FOXO4 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 4303 |
| Chemical/Pharm GKB Gene | PA162388882 |
| Clinical trial | FOXO4 |
| Miscellaneous |
|---|
| canSAR (ICR) | FOXO4 (select the gene name) |
| DataMed Index | FOXO4 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 101 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | FOXO4 |
| EVEX | FOXO4 |
| GoPubMed | FOXO4 |
| iHOP | FOXO4 |
