| Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23). |
| Borkhardt A, Repp R, Haas OA, Leis T, Harbott J, Kreuder J, Hammermann J, Henn T, Lampert F |
| Oncogene. 1997 ; 14 (2) : 195-202. |
| PMID 9010221 |
| |
| Direct control of the Forkhead transcription factor AFX by protein kinase B. |
| Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, Burgering BM |
| Nature. 1999 ; 398 (6728) : 630-634. |
| PMID 10217147 |
| |
| AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. |
| Medema RH, Kops GJ, Bos JL, Burgering BM |
| Nature. 2000 ; 404 (6779) : 782-787. |
| PMID 10783894 |
| |
| Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family. |
| Parry P, Wei Y, Evans G |
| Genes, chromosomes & cancer. 1994 ; 11 (2) : 79-84. |
| PMID 7529552 |
| |
| AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as candidate genes of X-linked dystonia parkinsonism. |
| Peters U, Haberhausen G, Kostrzewa M, Nolte D, Müller U |
| Human genetics. 1997 ; 100 (5-6) : 569-572. |
| PMID 9341872 |
| |
| Nomenclature |
|---|
| HGNC (Hugo) | FOXO4 7139 |
| Cards |
|---|
| Atlas | AFX1ID57 |
| Entrez_Gene (NCBI) | FOXO4 4303 forkhead box O4 |
| Aliases | AFX; AFX1; MLLT7 |
| GeneCards (Weizmann) | FOXO4 |
| Ensembl hg19 (Hinxton) | ENSG00000184481 [Gene_View] chrX:70315999-70323384 [Contig_View] FOXO4 [Vega] |
| Ensembl hg38 (Hinxton) | ENSG00000184481 [Gene_View] chrX:70315999-70323384 [Contig_View] FOXO4 [Vega] |
| ICGC DataPortal | ENSG00000184481 |
| TCGA cBioPortal | FOXO4 |
| AceView (NCBI) | FOXO4 |
| Genatlas (Paris) | FOXO4 |
| WikiGenes | 4303 |
| SOURCE (Princeton) | FOXO4 |
| Genomic and cartography |
|---|
| GoldenPath hg19 (UCSC) | FOXO4 - chrX:70315999-70323384 + Xq13.1 [Description] (hg19-Feb_2009) |
| GoldenPath hg38 (UCSC) | FOXO4 - Xq13.1 [Description] (hg38-Dec_2013) |
| Ensembl | FOXO4 - Xq13.1 [CytoView hg19] FOXO4 - Xq13.1 [CytoView hg38] |
| Mapping of homologs : NCBI | FOXO4 [Mapview hg19] FOXO4 [Mapview hg38] |
| OMIM | 300033 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF384029 AK300142 AW292413 BC026735 BC106761 |
| RefSeq transcript (Entrez) | NM_001170931 NM_005938 |
| RefSeq genomic (Entrez) | NC_000023 NC_018934 NG_016418 NT_011651 NW_004929443 |
| Consensus coding sequences : CCDS (NCBI) | FOXO4 |
| Cluster EST : Unigene | Hs.584654 [ NCBI ] |
| CGAP (NCI) | Hs.584654 |
| Alternative Splicing Gallery | ENSG00000184481 |
| Gene Expression | FOXO4 [ NCBI-GEO ] FOXO4 [ EBI - ARRAY_EXPRESS ]
FOXO4 [ SEEK ] FOXO4 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | FOXO4 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 4303 |
| GTEX Portal (Tissue expression) | FOXO4 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P98177 (Uniprot) |
| NextProt | P98177 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P98177 |
| Splice isoforms : SwissVar | P98177 (Swissvar) |
| PhosPhoSitePlus | P98177 |
| Domaine pattern : Prosite (Expaxy) | FORK_HEAD_2 (PS00658) FORK_HEAD_3 (PS50039) |
| Domains : Interpro (EBI) | Fork_head_dom FOXO-TAD TF_fork_head_CS_2 WHTH_DNA-bd_dom |
| Domain families : Pfam (Sanger) | Forkhead (PF00250) FOXO-TAD (PF16676) |
| Domain families : Pfam (NCBI) | pfam00250 pfam16676 |
| Domain families : Smart (EMBL) | FH (SM00339) |
| DMDM Disease mutations | 4303 |
| Blocks (Seattle) | FOXO4 |
| PDB (SRS) | 1E17 3L2C |
| PDB (PDBSum) | 1E17 3L2C |
| PDB (IMB) | 1E17 3L2C |
| PDB (RSDB) | 1E17 3L2C |
| Structural Biology KnowledgeBase | 1E17 3L2C |
| SCOP (Structural Classification of Proteins) | 1E17 3L2C |
| CATH (Classification of proteins structures) | 1E17 3L2C |
| Superfamily | P98177 |
| Human Protein Atlas | ENSG00000184481 |
| Peptide Atlas | P98177 |
| HPRD | 02070 |
| IPI | IPI00024316 IPI00220121 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P98177 |
| IntAct (EBI) | P98177 |
| FunCoup | ENSG00000184481 |
| BioGRID | FOXO4 |
| STRING (EMBL) | FOXO4 |
| ZODIAC | FOXO4 |
| Ontologies - Pathways |
|---|
| QuickGO | P98177 |
| Ontology : AmiGO | RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytosol cytosol regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cell cycle arrest mitotic G2 DNA damage checkpoint muscle organ development beta-catenin binding transcription factor binding negative regulation of cell proliferation insulin receptor signaling pathway negative regulation of angiogenesis enzyme binding identical protein binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter stem cell differentiation negative regulation of smooth muscle cell differentiation negative regulation of G0 to G1 transition positive regulation of cell cycle arrest |
| Ontology : EGO-EBI | RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytosol cytosol regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cell cycle arrest mitotic G2 DNA damage checkpoint muscle organ development beta-catenin binding transcription factor binding negative regulation of cell proliferation insulin receptor signaling pathway negative regulation of angiogenesis enzyme binding identical protein binding sequence-specific DNA binding positive regulation of transcription from RNA polymerase II promoter stem cell differentiation negative regulation of smooth muscle cell differentiation negative regulation of G0 to G1 transition positive regulation of cell cycle arrest |
| Pathways : BIOCARTA | AKT Signaling Pathway [Genes] Ras Signaling Pathway [Genes] |
| Pathways : KEGG | Ras signaling pathway FoxO signaling pathway |
| NDEx Network | FOXO4 |
| Atlas of Cancer Signalling Network | FOXO4 |
| Wikipedia pathways | FOXO4 |
| Orthology - Evolution |
|---|
| OrthoDB | 4303 |
| GeneTree (enSembl) | ENSG00000184481 |
| Phylogenetic Trees/Animal Genes : TreeFam | FOXO4 |
| Homologs : HomoloGene | FOXO4 |
| Homology/Alignments : Family Browser (UCSC) | FOXO4 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | CIC/FOXO4 [19q13.2/Xq13.1] [t(X;19)(q13;q13)] |
| Fusion : Mitelman | PAX3/FOXO4 [2q36.1/Xq13.1] [t(X;2)(q13;q36)] |
| Fusion : COSMIC | KMT2A [11q23.3] - FOXO4 [Xq13.1] [fusion_1976] |
| Polymorphisms : SNP, variants |
|---|
| NCBI Variation Viewer | FOXO4 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | FOXO4 |
| dbVar | FOXO4 |
| ClinVar | FOXO4 |
| 1000_Genomes | FOXO4 |
| Exome Variant Server | FOXO4 |
| ExAC (Exome Aggregation Consortium) | FOXO4 (select the gene name) |
| Genetic variants : HAPMAP | 4303 |
| Genomic Variants (DGV) | FOXO4 [DGVbeta] |
| Mutations |
|---|
| ICGC Data Portal | FOXO4 |
| TCGA Data Portal | FOXO4 |
| Broad Tumor Portal | FOXO4 |
| OASIS Portal | FOXO4 [ Somatic mutations - Copy number] |
| Cancer Gene: Census | FOXO4 |
| Somatic Mutations in Cancer : COSMIC | FOXO4 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | X-chromosome gene database |
| BioMuta | search FOXO4 |
| DgiDB (Drug Gene Interaction Database) | FOXO4 |
| DoCM (Curated mutations) | FOXO4 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | FOXO4 (select a term) |
| intoGen | FOXO4 |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] |
| Diseases |
|---|
| DECIPHER (Syndromes) | X:70315999-70323384 ENSG00000184481 |
| CONAN: Copy Number Analysis | FOXO4 |
| Mutations and Diseases : HGMD | FOXO4 |
| OMIM | 300033 |
| Medgen | FOXO4 |
| Genetic Testing Registry | FOXO4
|
| NextProt | P98177 [Medical] |
| TSGene | 4303 |
| GENETests | FOXO4 |
| Huge Navigator |
FOXO4 [HugePedia] |
| snp3D : Map Gene to Disease | 4303 |
| BioCentury BCIQ | FOXO4 |
| ClinGen | FOXO4 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 4303 |
| Chemical/Pharm GKB Gene | PA162388882 |
| Clinical trial | FOXO4 |
| Miscellaneous |
|---|
| canSAR (ICR) | FOXO4 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 84 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | FOXO4 |
| EVEX | FOXO4 |
| GoPubMed | FOXO4 |
| iHOP | FOXO4 |
