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CDC25A (Cell division cycle 25A)

Written2015-08Christine Dozier, Stéphane Manenti
Cancer Research Center of Toulouse (CRCT), UMR1037 INSERM, ERL5294 CNRS, Université Toulouse III Paul Sabatier, Toulouse, France.
This article is an update of :
2008-02Dipankar Ray, Hiroaki Kiyokawa
Dept. of Mol. Pharmacol & Biol. Chem, Northwestern University, Chicago, IL 60611, USA (DR, HK); Robert H. Lurie Compre. Cancer Center, Northwestern University, Chicago, IL 60611, USA (HK)

Abstract CDC25A phosphatase is essential for cell cycle progression by activating the cyclin-associated kinases CDK4/6, CDK2 and CDK1. Its invalidation in mice is embryonic lethal. Its expression is tigthtly regulated at many levels and its overexpression is observed in various cancers, often associated with high grade tumors and poor prognosis.

Keywords CDC25, cell cycle, CDK/cyclin, apoptosis

(Note : for Links provided by Atlas : click)


Alias (NCBI)CDC25A2
HGNC (Hugo) CDC25A
HGNC Alias nameCDC25 homolog A (S. pombe)
LocusID (NCBI) 993
Atlas_Id 40004
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 48157146 and ends at 48188417 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping CDC25A.png]
Local_order The gene is located telomeric to (cathelicidin antimicrobial peptide) and centromeric to LOC729349 (a pseudogene similar to 60S ribosomal protein L17 (L23)). The gene starts at 48,173,672 bp from pter and ends at 48,204,805 bp from pter with a total size of 31,133 bases.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDC25A (3p21.31)::CDC25A (3p21.31)CDC25A (3p21.31)::PAFAH1B2 (11q23.3)CDC25A (3p21.31)::PRKAR2A (3p21.31)
CDC25A (3p21.31)::SPINK8 (3p21.31)MAP4 (3p21.31)::CDC25A (3p21.31)


  Genomic organization of human CDC25A gene on chromosome 3 p-ter.
Description CDC25A is about 31.13 Kb located on the short (p) arm of chromosome 3, in the centromere-to-telomere orientation. The gene has 15 exons and the start codon is located at the end of exon 1 and stop codon in the beginning of exon 15.
Transcription The CDC25A transcript is 3704 bp in length. So far two major transcript variant have been reported, CDC25A1 and A2. The transcript variant CDC25A2, has a deletion of 120 nucleotides (exon 6) resulting in a protein having truncation of 40 amino acids (between amino acid 160-201). However, both the N-terminal and C-terminal end of the protein is the same in both splice variant.


  Domains of different isoforms of CDC25A (A1 and A2). The splice variant A2 lacks an in-frame exon (exon 6) encoding 40 amino acids (amino acid 160-201), however, has the same N- and C-termini compared to isoform A1. The approx. molecular weight of each isoform is mentioned in parenthesis.
Description The full length CDC25A protein consists of 524 amino acids with an estimated molecular weight of 59 kDa. The other reported isoform CDC25A2, consists of 484 amino acids with a molecular weight of 54.4 kDa (Wegener et al., 2000).. Both the isoforms have the same N- and C-terminal end, thus expected to have similar catalytic activity. The N-terminal regulatory domain contains several phosphorylation sites and shows low sequence homology between CDC25 family members, whereas C-terminal end has conserved Rhodanese homology domain containing the active site cysteine. The catalytic site contain the CX5R motif (C= cysteine; X= any amino acid; R= arginine) common to all protein tyrosine phosphatases (Boutros et al., 2006). Upon apoptosis induction, CDC25A is cleaved at D223 (D=Aspartic acid) by caspase to generate a catalytically active CDC25A C-terminal 37Kda protein (Mazars et al., 2009; Chou et al., 2010).
Expression CDC25A is expressed early during embryonic stages and in adults it is expressed in a variety of normal cells and tissues. CDC25A is a highly expressed gene in a variety of human cancers including breast, esophageal, gastric, lung, thyroid, head and neck cancers and also in high grade lymphomas.
Localisation CDC25A initially believed to be a nuclear protein. But using fluorescence loss in photobleaching (FLIP) a more dynamic nuclear-cytosolic shuttling of CDC25A localization has been reported. At the very N-terminus end between amino acid 38-59, the nuclear export sequence (NES) is located, whereas between amino acid 272-294, a bipartite nuclear localization signal (NLS) was proved to be important for its nuclear localization (Källström et al., 2005). Depending of the cell line, CDC25A is nuclear or nuclear and cytoplasmic.
Function - CDC25A is essential for early embryonic development as Cdc25A-null mice die in utero by embryonic day 7(Ray et al., 2007).
- It is a member of the M-phase inducer (MPI) phosphatase family protein, which not only regulates mitotic progression by activating mitotic CDKs in a dosage-dependent manner, it is also equally important in G1 and for G1 to S-phase transition.
- During G1, CDC25A dephosphorylates CDK4/CDK6 on tyrosine 17 and 24, respectively, allowing their association with D-type cyclins and thus their activation (Bertero et al., 2013). During G1 to S transition, it activates CDK2 by removing two inhibitory phosphates on residues threonine 14 and tyrosine 15. During G2/M transition CDC25A similarly regulates the activity of CDK1 (CDC2).
- It is an inhibitor of apoptosis by inhibiting apoptosis signal-regulating kinase 1 (ASK1). in a phosphatase-independent manner, by activating the AKT-survival pathway in the cytoplasm and also by stimulating NF-kB activity through NFKBIA (IκB- α) destabilization (review Fernandez-Vidal et al., 2008; review Shen and Huang, 2012; Hong et al., 2012). But overexpressed nuclear CDC25A also exhibits pro apoptotic activity by activating the pro-apoptotic factor FKHLR1 (review Fernandez-Vidal et al., 2008; review Shen and Huang, 2012).
- CDC25A plays an important role in spermatogenesis as decreased transcript level of Cdc25A is correlated with spermatogenic failure and failed sperm retrieval in infertile men. (Cheng et al., 2009).
-CDC25A also plays a role in meiotic maturation of oocytes, its activity is required for the metaphase II arrest in mouse oocytes (Oh et al., 2013).
- CDC25A was shown to function as a androgen receptor corepressor in prostate cancer cells (Chiu et al., 2009).
- CDC25A is transcriptionally regulated by E2F, a transcription factor implicated at the G1/S transition, c-myc, STAT3, the p53-pathway via the transcription factor ATF3, TCF/beta-catenin, FOXM1, NANOG in embryonic stem cell and PROX1 in neural precursor (review Fernandez-Vidal et al., 2008; review Shen and Huang, 2012).
- CDC25A is also regulated at the translational level by the translation initiation factors EIF2S1 (eIF2alpha), EIF3M, the RNA-binding proteins BOLL in spermatogenesis, and various miRNAs such as let7b, 15a, 21, 449a, 449b, 483-3p, 424/503 cluster and 141-3p. Some of these miRNAs being deregulated in cancers can contribute to the overexpression of CDC25A in cancers.
- CDC25A activity can be regulated by phosphorylation events (review Fernandez-Vidal et al., 2008; review Shen and Huang, 2012). The kinases PIM-1, RAF1, CDK2, RSK, ROCK1 (p160Rock) and the phosphatase CDC14B have been shown to regulate CDC25A activity. The kinase CHK1 has been shown to phosphorylate CDC25A on serine 178 and threonine 507 preventing its interaction with its CDK/cyclin substrates.
- CDC25A is an unstable protein in interphase, or under several different stress conditions (DNA damage induced by ionizing radiation, ultraviolet light, replicative stress) being degraded by the proteasome after ubiquitination by SCFβTrCP E3 ubiquitin ligase. This ubiquitination is dependent on several phosphorylation events in the N-terminal part of the protein carried out by many kinases such as CHK1 (on serine 76, 124, 178, 279 and 293), CHK2 (on serine 124, 178 and 293), p38MAPK (on serine 76), GSK3-β (on serine 76), Plk3 (on threonine 80), NEK11 (on serine 82 and 88) and CK1alpha and epsilon (on serine 82) (review Fernandez-Vidal et al., 2008; review Shen and Huang, 2012).
- CDC25A protein is stabilized during mitosis due to phosphorylation on serine 18 and 116 by CDK1/cyclinB occuring at the G2/M transition (Mailand et al., 2002). At the mitotic exit and in early G1, CDC25A is degraded by the proteasome after ubiquitination by the E3 ubiquitine ligase APC/C (cyclosome) (review Fernandez-Vidal et al., 2008; review Shen and Huang, 2012).
- CDC25A protein level is important for oncogene-induced transformation and mouse mammary tumor virus (MMTV)-neu/ras induced mammary tumorigenesis (Ray et al., 2007).
- During early cell cycle progression glycogen synthase kinase 3-beta (GSK-3β) can phosphorylate allowing its proteasomal degradation. Interestingly, the same report showed that overproduction of CDC25A in some human cancers is correlated to the inactivation of GSK-3β (Kang et al., 2008).
- Overexpression of CDC25A in some human sarcomas has also been shown to be the result of transcriptional upregulation involving the transcription factor TCF/β-catenin upregulated upon activation of the wnt canonical signaling (Vijayakumar et al.,2011). HOMOLOGY CDC25A gene is highly conserved among mammals (99% homology with Chimpanzee; 90% with dog; about 86% with rat and about 85% with mouse). In mammals, CDC25A has two orthologs, CDC25B and CDC25C. Among them, the N-terminal regulatory region show low sequence homology (20-25% identity), however, the C-terminal catalytic region is quite conserved with about 64% homology with CDC25B and about 58% homology to CDC25C.


Note Gene mutation or amplification is not commonly reported for CDC25A. A naturally occurring point mutation (C to A) of mouse Cdc25A gene has been reported where Histidine 128 (CAC) has been converted to Glutamine (CAA). This change caused an increase in CDC25A phosphatase activity and thereby affected erythropoiesis in mice only under certain genetic background (Melkun et al., 2002). A human polymorphism variant in which Serine 88 is converted to Phenylalanine has been described. This variant fails to interact with ASK1 and therefore does not suppress ASK1-mediated apoptosis, which leads to early embryonic lethality in mice and predisposes to cancer in human (Bahassi et al. 2011)..

Implicated in

Note - CDC25A is overexpressed in a variety of human cancers including breast, hepatocellular, ovarian, colorectal, gastric, lung, thyroid, esophageal, laryngeal, head and neck cancers, retinoblastoma, glioma, and also in non-Hodgkin lymphoma. often associated with high grade tumours and bad prognosis (Boutros et al., 2007).
- Upregulation of CDC25A is also observed down-stream of the NPM1 / ALK oncogene in anaplastic large cell lymphoma and participates to their enhanced proliferation (Fernandez-Vidal et al., 2009). - CDC25A is overexpressed in erythroleukemia cell lines expressing the JAK2V617F oncogene, present in the majority of patients with polycythemia vera and one-half of those with essential thrombocythemia and primary myelofibrosis. This upregulation occurs at the translational level through the transcription factor STAT5 and the translational initiation factor eIF2alpha (Gautier et al., 2012).
- An upregulation of CDC25A activity due to its phosphorylation by deregulated CDK5 has been observed in Alzheimer's disease (Chang et al., 2012).
Entity Breast cancer
Note - In about 47% of early (T1) stage breast cancer patients CDC25A is reported to be overexpressed.
- In some breast cancer cell lines it was reported that CDC25A overexpression is mainly due to increased protein stability as oppose to gene amplification or transcriptional upregulation. (Löffler et al., 2003). In a subset of human breast cancers overexpression of the ubiquitin hydrolase DUB3, which deubiquitinates CDC25A preventing its degradation, is shown to be responsible for overexpression of CDC25A (Pereg et al., 2010).
- In mice, overexpression of CDC25A alone in mammary gland using mouse mammary tumor virus (MMTV) promoter, is not sufficient to induce mammary tumorigenesis. However, such mammary specific overexpression of CDC25A does cooperate with HER2/neu-ras signaling to form more aggressive tumors with enhanced genomic instability. (Ray et al., 2007).
- In contrast, hemizygous loss of Cdc25A in mice protected them significantly from MMTV-neu/ras-induced mammary tumorigenesis, possibly by restricting precancerous cell proliferation and also by enhancing G2-checkpoint response. Thus the protein level of CDC25A is crucial for the initiation and/or progression of breast tumorigenesis in mice (Ray and Kiyokawa, 2007).
Prognosis Overexpression of CDC25A is correlated with more aggressive breast cancer with poor prognosis.
Cytogenetics CDC25A overexpression in MMTV-CDC25A; MMTV-neu double transgenic mice caused faster tumor growth as compared to MMTV-neu single transgenic mice. Importantly, such CDC25A overexpressing tumor cells displayed miscoordination of S phase and mitosis, and had severe genomic instability as evidenced by aneuploidy and deletion of fragile chromosomal regions (e.g., telomeric region of chromosome 4, which is homologous to human chromosome 1p31-36, a hotspot for several human cancers including breast cancer).
Entity Hepatocellular carcinoma
Note Overexpression of CDC25A mRNAs was found in 69% of hepatocellular carcinomas (HCCs) and this overexpression was also confirmed by Immunohistochemistry (56% HCCs exhibit overexpression of CDC25A) and western blot analysis (Xu et al., 2003). Different CDC25 inhibitor (such as vitamin K analog Cpd 5; phenyl maleimide compound PM-20; 2-Methoxyestadiol, a physiological metabolite of estrogen) are capable of inhibiting the hepatocellular carcinoma growth both in vitro and in vivo (Wang et al., 2001; Kar et al, 2006).
Disease High expression of CDC25A was associated with dedifferentiated phenotype and portal vein invasion.
Prognosis CDC25A overexpression is associated with poor prognosis of hepatocellular carcinoma.
Entity Retinoblastoma
Note Overexpression of CDC25A mRNAs was found in 48,33 % retinoblastomas, confirmed by immunohistochemistry (52,29 %) and western blotting (Shingh et al., 2014).
Prognosis Expression of CDC25A showed significant correlation with poor tumour differentiation and tumour invasion.
Entity Non-Hodgkin's lymphoma
Prognosis High level of CDC25A mRNAs was found in 35 % of the tumors and were more frequently observed in aggressive than in indolent lymphomas. This was also confirmed at the protein level.
Entity Gastric cancer
Note By immunohistochemistry CDC25A was found expressed in 87.1 % of gastric carcinomas, correlated with c-myc overexpression (Xing et al., 2008).
Disease Overexpression of CDC25A was independent of intestinal or diffuse type of gastric cancer.
Prognosis Association between CDC25A expression and higher histological grade of differentiation.


A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis
Bahassi el M, Yin M, Robbins SB, Li YQ, Conrady DG, Yuan Z, Kovall RA, Herr AB, Stambrook PJ
Cell Div 2011 Feb 10;6(1):4
PMID 21310058
Mammalian G1- and S-phase checkpoints in response to DNA damage
Bartek J, Lukas J
Curr Opin Cell Biol 2001 Dec;13(6):738-47
PMID 11698191
CDC25A targeting by miR-483-3p decreases CCND-CDK4/6 assembly and contributes to cell cycle arrest
Bertero T, Gastaldi C, Bourget-Ponzio I, Mari B, Meneguzzi G, Barbry P, Ponzio G, Rezzonico R
Cell Death Differ 2013 Jun;20(6):800-11
PMID 23429262
The when and wheres of CDC25 phosphatases
Boutros R, Dozier C, Ducommun B
Curr Opin Cell Biol 2006 Apr;18(2):185-91
PMID 16488126
CDC25 phosphatases in cancer cells: key players? Good targets? Nat Rev Cancer
Boutros R, Lobjois V, Ducommun B
2007 Jul;7(7):495-507 Review
PMID 17568790
Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death
Chang KH, Vincent F, Shah K
J Cell Sci 2012 Nov 1;125(Pt 21):5124-37
PMID 22899714
Association of spermatogenic failure with decreased CDC25A expression in infertile men
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Hum Reprod 2006 Sep;21(9):2346-52
PMID 16720623
CDC25A functions as a novel Ar corepressor in prostate cancer cells
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J Mol Biol 2009 Jan 16;385(2):446-56
PMID 19013180
Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain
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J Biol Chem 2010 Jun 4;285(23):17833-45
PMID 20368335
Chromosome mapping of human CDC25A and CDC25B phosphatases
Demetrick DJ, Beach DH
Genomics 1993 Oct;18(1):144-7
PMID 8276402
Upregulation of the CDC25A phosphatase down-stream of the NPM/ALK oncogene participates to anaplastic large cell lymphoma enhanced proliferation
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Cell Cycle 2009 May 1;8(9):1373-9
PMID 19305144
Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins
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Cell 1991 Dec 20;67(6):1181-94
PMID 1836978
The cell cycle regulator CDC25A is a target for JAK2V617F oncogene
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Blood 2012 Feb 2;119(5):1190-9
PMID 22065597
Cdc25A promotes cell survival by stimulating NF-B activity through I@kappa;B-@beta; phosphorylation and destabilization
Hong HY, Choi J, Cho YW, Kim BC
Biochem Biophys Res Commun 2012 Apr 6;420(2):293-6
PMID 22417828
Cdc25A localisation and shuttling: characterisation of sequences mediating nuclear export and import
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Exp Cell Res 2005 Feb 1;303(1):89-100
PMID 15572030
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers
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PMID 18167338
2-Methoxyestradiol inhibits hepatocellular carcinoma cell growth by inhibiting Cdc25 and inducing cell cycle arrest and apoptosis
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PMID 18246350
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PMID 14603247
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Science 2000 May 26;288(5470):1425-9
PMID 10827953
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PMID 12411508
A caspase-dependent cleavage of CDC25A generates an active fragment activating cyclin-dependent kinase 2 during apoptosis
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PMID 18927589
A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells
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Blood 2002 Nov 15;100(10):3804-11
PMID 12411323
Cdc25A activity is required for the metaphase II arrest in mouse oocytes
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J Cell Sci 2013 Mar 1;126(Pt 5):1081-5
PMID 23345398
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
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Nat Cell Biol 2010 Apr;12(4):400-6
PMID 20228808
CDC25A levels determine the balance of proliferation and checkpoint response
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Cell Cycle 2007 Dec 15;6(24):3039-42
PMID 18073536
Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice
Ray D, Terao Y, Nimbalkar D, Hirai H, Osmundson EC, Zou X, Franks R, Christov K, Kiyokawa H
Cancer Res 2007 Jul 15;67(14):6605-11
PMID 17638870
The role of Cdc25A in the regulation of cell proliferation and apoptosis
Shen T, Huang S
Anticancer Agents Med Chem 2012 Jul;12(6):631-9
PMID 22263797
Expression of CDC25A and CDC25B phosphatase proteins in human retinoblastoma and its correlation with clinicopathological parameters
Singh L, Pushker N, Sen S, Singh MK, Bakhshi S, Chawla B, Kashyap S
Br J Ophthalmol 2015 Apr;99(4):457-63
PMID 25326518
High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/-catenin target gene, CDC25A
Vijayakumar S, Liu G, Rus IA, Yao S, Chen Y, Akiri G, Grumolato L, Aaronson SA
Cancer Cell 2011 May 17;19(5):601-12
PMID 21575861
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Cancer Res 2001 Oct 1;61(19):7211-6
PMID 11585757
Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C
Wegener S, Hampe W, Herrmann D, Schaller HC
Eur J Cell Biol 2000 Nov;79(11):810-5
PMID 11139144
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents
Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H
J Biol Chem 2003 Jun 13;278(24):21767-73
Expression of CDC25 phosphatases in human gastric cancer
Xing X, Chen J, Chen M
Dig Dis Sci 2008 Apr;53(4):949-53
PMID 17934831
Overexpression of CDC25A phosphatase is associated with hypergrowth activity and poor prognosis of human hepatocellular carcinomas
Xu X, Yamamoto H, Sakon M, Yasui M, Ngan CY, Fukunaga H, Morita T, Ogawa M, Nagano H, Nakamori S, Sekimoto M, Matsuura N, Monden M
Clin Cancer Res 2003 May;9(5):1764-72
PMID 12738732
The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1
Zou X, Tsutsui T, Ray D, Blomquist JF, Ichijo H, Ucker DS, Kiyokawa H
Mol Cell Biol 2001 Jul;21(14):4818-28
PMID 11416155


This paper should be referenced as such :
Christine Dozier, Stephane Manenti
CDC25A (Cell division cycle 25A)
Atlas Genet Cytogenet Oncol Haematol. ;20(6):316-321.
Free journal version : [ pdf ]   [ DOI ]
History of this paper:
Ray, D ; Kiyokawa, H. CDC25A (cell division cycle 25A). Atlas Genet Cytogenet Oncol Haematol. 2008;12(6):421-424.

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;6)(q27;p21) PIM1::BCL6

External links


HGNC (Hugo)CDC25A   1725
Entrez_Gene (NCBI)CDC25A    cell division cycle 25A
GeneCards (Weizmann)CDC25A
Ensembl hg19 (Hinxton)ENSG00000164045 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164045 [Gene_View]  ENSG00000164045 [Sequence]  chr3:48157146-48188417 [Contig_View]  CDC25A [Vega]
ICGC DataPortalENSG00000164045
TCGA cBioPortalCDC25A
AceView (NCBI)CDC25A
Genatlas (Paris)CDC25A
SOURCE (Princeton)CDC25A
Genetics Home Reference (NIH)CDC25A
Genomic and cartography
GoldenPath hg38 (UCSC)CDC25A  -     chr3:48157146-48188417 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDC25A  -     3p21.31   [Description]    (hg19-Feb_2009)
GoldenPathCDC25A - 3p21.31 [CytoView hg19]  CDC25A - 3p21.31 [CytoView hg38]
Genome Data Viewer NCBICDC25A [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AF277722 AI917350 AK290554 AY137580 BC007401
RefSeq transcript (Entrez)NM_001789 NM_201567
Consensus coding sequences : CCDS (NCBI)CDC25A
Gene ExpressionCDC25A [ NCBI-GEO ]   CDC25A [ EBI - ARRAY_EXPRESS ]   CDC25A [ SEEK ]   CDC25A [ MEM ]
Gene Expression Viewer (FireBrowse)CDC25A [ Firebrowse - Broad ]
GenevisibleExpression of CDC25A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)993
GTEX Portal (Tissue expression)CDC25A
Human Protein AtlasENSG00000164045-CDC25A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30304   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30304  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30304
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ] [ IntEnz-EBI ] [ BRENDA ] [ KEGG ]   [ MEROPS ]
Domaine pattern : Prosite (Expaxy)RHODANESE_3 (PS50206)   
Domains : Interpro (EBI)MPI_Phosphatase    Rhodanese-like_dom    Rhodanese-like_dom_sf   
Domain families : Pfam (Sanger)M-inducer_phosp (PF06617)    Rhodanese (PF00581)   
Domain families : Pfam (NCBI)pfam06617    pfam00581   
Domain families : Smart (EMBL)RHOD (SM00450)  
Conserved Domain (NCBI)CDC25A
PDB (RSDB)1C25   
PDB Europe1C25   
PDB (PDBSum)1C25   
PDB (IMB)1C25   
Structural Biology KnowledgeBase1C25   
SCOP (Structural Classification of Proteins)1C25   
CATH (Classification of proteins structures)1C25   
AlphaFold pdb e-kbP30304   
Human Protein Atlas [tissue]ENSG00000164045-CDC25A [tissue]
Protein Interaction databases
IntAct (EBI)P30304
Ontologies - Pathways
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  protein tyrosine phosphatase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cell population proliferation  response to radiation  positive regulation of G2/M transition of mitotic cell cycle  protein deubiquitination  protein kinase binding  cellular response to UV  peptidyl-tyrosine dephosphorylation  chaperone binding  cell division  regulation of cell cycle  positive regulation of G2/MI transition of meiotic cell cycle  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  protein tyrosine phosphatase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cell population proliferation  response to radiation  positive regulation of G2/M transition of mitotic cell cycle  protein deubiquitination  protein kinase binding  cellular response to UV  peptidyl-tyrosine dephosphorylation  chaperone binding  cell division  regulation of cell cycle  positive regulation of G2/MI transition of meiotic cell cycle  
Pathways : BIOCARTARB Tumor Suppressor/Checkpoint Signaling in response to DNA damage [Genes]    Cell Cycle: G2/M Checkpoint [Genes]    Cyclins and Cell Cycle Regulation [Genes]    cdc25 and chk1 Regulatory Pathway in response to DNA damage [Genes]    Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle [Genes]    Activation of Src by Protein-tyrosine phosphatase alpha [Genes]    Cell Cycle: G1/S Check Point [Genes]   
Pathways : KEGGCell cycle    Progesterone-mediated oocyte maturation    MicroRNAs in cancer   
REACTOMEP30304 [protein]
REACTOME PathwaysR-HSA-8862803 [pathway]   
NDEx NetworkCDC25A
Atlas of Cancer Signalling NetworkCDC25A
Wikipedia pathwaysCDC25A
Orthology - Evolution
GeneTree (enSembl)ENSG00000164045
Phylogenetic Trees/Animal Genes : TreeFamCDC25A
Homologs : HomoloGeneCDC25A
Homology/Alignments : Family Browser (UCSC)CDC25A
Gene fusions - Rearrangements
Fusion : MitelmanCDC25A::PRKAR2A [3p21.31/3p21.31]  
Fusion : MitelmanCDC25A::SPINK8 [3p21.31/3p21.31]  
Fusion : MitelmanMAP4::CDC25A [3p21.31/3p21.31]  
Fusion : QuiverCDC25A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDC25A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDC25A
Exome Variant ServerCDC25A
GNOMAD BrowserENSG00000164045
Varsome BrowserCDC25A
ACMGCDC25A variants
Genomic Variants (DGV)CDC25A [DGVbeta]
DECIPHERCDC25A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDC25A 
ICGC Data PortalCDC25A 
TCGA Data PortalCDC25A 
Broad Tumor PortalCDC25A
OASIS PortalCDC25A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDC25A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDC25A
Mutations and Diseases : HGMDCDC25A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)CDC25A
DoCM (Curated mutations)CDC25A
CIViC (Clinical Interpretations of Variants in Cancer)CDC25A
NCG (London)CDC25A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry CDC25A
NextProtP30304 [Medical]
Target ValidationCDC25A
Huge Navigator CDC25A [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDCDC25A
Pharm GKB GenePA26259
Clinical trialCDC25A
DataMed IndexCDC25A
PubMed204 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:14:35 CEST 2021

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