CDKs give Cdc6 a license to drive into S phase. |
Ayad NG |
Cell. 2005 ; 122 (6) : 825-827. |
PMID 16179249 |
|
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. |
Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Ørntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG |
Nature. 2006 ; 444 (7119) : 633-637. |
PMID 17136093 |
|
Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle. |
Biermann E, Baack M, Kreitz S, Knippers R |
European journal of biochemistry / FEBS. 2002 ; 269 (3) : 1040-1046. |
PMID 11846807 |
|
Targeted destruction of DNA replication protein Cdc6 by cell death pathways in mammals and yeast. |
Blanchard F, Rusiniak ME, Sharma K, Sun X, Todorov I, Castellano MM, Gutierrez C, Baumann H, Burhans WC |
Molecular biology of the cell. 2002 ; 13 (5) : 1536-1549. |
PMID 12006651 |
|
Immunohistochemical localization of cdc6 in squamous and glandular neoplasia of the uterine cervix. |
Bonds L, Baker P, Gup C, Shroyer KR |
Archives of pathology & laboratory medicine. 2002 ; 126 (10) : 1164-1168. |
PMID 12296751 |
|
CDC6: from DNA replication to cell cycle checkpoints and oncogenesis. |
Borlado LR, Méndez J |
Carcinogenesis. 2008 ; 29 (2) : 237-243. |
PMID 18048387 |
|
Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1. |
Clay-Farrace L, Pelizon C, Santamaria D, Pines J, Laskey RA |
The EMBO journal. 2003 ; 22 (3) : 704-712. |
PMID 12554670 |
|
The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. |
Cook JG, Chasse DA, Nevins JR |
The Journal of biological chemistry. 2004 ; 279 (10) : 9625-9633. |
PMID 14672932 |
|
Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. |
Cook JG, Park CH, Burke TW, Leone G, DeGregori J, Engel A, Nevins JR |
Proceedings of the National Academy of Sciences of the United States of America. 2002 ; 99 (3) : 1347-1352. |
PMID 11805305 |
|
Chromatin-bound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process. |
Coverley D, Pelizon C, Trewick S, Laskey RA |
Journal of cell science. 2000 ; 113 ( Pt 11) : 1929-1938. |
PMID 10806104 |
|
Multiple mechanisms regulate subcellular localization of human CDC6. |
Delmolino LM, Saha P, Dutta A |
The Journal of biological chemistry. 2001 ; 276 (29) : 26947-26954. |
PMID 11346650 |
|
p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation. |
Duursma A, Agami R |
Molecular and cellular biology. 2005 ; 25 (16) : 6937-6947. |
PMID 16055707 |
|
Nuclear organization of DNA replication initiation proteins in mammalian cells. |
Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T |
The Journal of biological chemistry. 2002 ; 277 (12) : 10354-10361. |
PMID 11779870 |
|
Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation. |
Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T |
The Journal of biological chemistry. 1999 ; 274 (36) : 25927-25932. |
PMID 10464337 |
|
Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. |
Gonzalez S, Klatt P, Delgado S, Conde E, Lopez-Rios F, Sanchez-Cespedes M, Mendez J, Antequera F, Serrano M |
Nature. 2006 ; 440 (7084) : 702-706. |
PMID 16572177 |
|
Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. |
Hall JR, Kow E, Nevis KR, Lu CK, Luce KS, Zhong Q, Cook JG |
Molecular biology of the cell. 2007 ; 18 (9) : 3340-3350. |
PMID 17567951 |
|
Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. |
Hateboer G, Wobst A, Petersen BO, Le Cam L, Vigo E, Sardet C, Helin K |
Molecular and cellular biology. 1998 ; 18 (11) : 6679-6697. |
PMID 9774682 |
|
Mutation of cyclin/cdk phosphorylation sites in HsCdc6 disrupts a late step in initiation of DNA replication in human cells. |
Herbig U, Griffith JW, Fanning E |
Molecular biology of the cell. 2000 ; 11 (12) : 4117-4130. |
PMID 11102512 |
|
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells. |
Herbig U, Marlar CA, Fanning E |
Molecular biology of the cell. 1999 ; 10 (8) : 2631-2645. |
PMID 10436018 |
|
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. |
Jiang W, Wells NJ, Hunter T |
Proceedings of the National Academy of Sciences of the United States of America. 1999 ; 96 (11) : 6193-6198. |
PMID 10339564 |
|
Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional control over hCdt1. |
Karakaidos P, Taraviras S, Vassiliou LV, Zacharatos P, Kastrinakis NG, Kougiou D, Kouloukoussa M, Nishitani H, Papavassiliou AG, Lygerou Z, Gorgoulis VG |
The American journal of pathology. 2004 ; 165 (4) : 1351-1365. |
PMID 15466399 |
|
The functional role of Cdc6 in S-G2/M in mammalian cells. |
Lau E, Zhu C, Abraham RT, Jiang W |
EMBO reports. 2006 ; 7 (4) : 425-430. |
PMID 16439999 |
|
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. |
Liontos M, Koutsami M, Sideridou M, Evangelou K, Kletsas D, Levy B, Kotsinas A, Nahum O, Zoumpourlis V, Kouloukoussa M, Lygerou Z, Taraviras S, Kittas C, Bartkova J, Papavassiliou AG, Bartek J, Halazonetis TD, Gorgoulis VG |
Cancer research. 2007 ; 67 (22) : 10899-10909. |
PMID 18006835 |
|
Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. |
Méndez J, Stillman B |
Molecular and cellular biology. 2000 ; 20 (22) : 8602-8612. |
PMID 11046155 |
|
CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. |
Mailand N, Diffley JF |
Cell. 2005 ; 122 (6) : 915-926. |
PMID 16153703 |
|
Quantitation of CDC6 and MCM5 mRNA in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix. |
Murphy N, Ring M, Heffron CC, Martin CM, McGuinness E, Sheils O, O'Leary JJ |
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2005 ; 18 (6) : 844-849. |
PMID 15696126 |
|
Cdc6 expression as a marker of proliferative activity in brain tumors. |
Ohta S, Koide M, Tokuyama T, Yokota N, Nishizawa S, Namba H |
Oncology reports. 2001 ; 8 (5) : 1063-1066. |
PMID 11496317 |
|
Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F. |
Ohtani K, Tsujimoto A, Ikeda M, Nakamura M |
Oncogene. 1998 ; 17 (14) : 1777-1785. |
PMID 9778043 |
|
Down to the origin: Cdc6 protein and the competence to replicate. |
Pelizon C |
Trends in cell biology. 2003 ; 13 (3) : 110-113. |
PMID 12628342 |
|
Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. |
Petersen BO, Wagener C, Marinoni F, Kramer ER, Melixetian M, Lazzerini Denchi E, Gieffers C, Matteucci C, Peters JM, Helin K |
Genes & development. 2000 ; 14 (18) : 2330-2343. |
PMID 10995389 |
|
Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instability. |
Pinyol M, Salaverria I, Bea S, Fern´ndez V, Colomo L, Campo E, Jares P |
International journal of cancer. Journal international du cancer. 2006 ; 119 (12) : 2768-2774. |
PMID 17036332 |
|
Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer. |
Robles LD, Frost AR, Davila M, Hutson AD, Grizzle WE, Chakrabarti R |
The Journal of biological chemistry. 2002 ; 277 (28) : 25431-25438. |
PMID 12006585 |
|
Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. |
Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A |
Molecular and cellular biology. 1998 ; 18 (5) : 2758-2767. |
PMID 9566895 |
|
Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells. |
Takeda DY, Shibata Y, Parvin JD, Dutta A |
Genes & development. 2005 ; 19 (23) : 2827-2836. |
PMID 16322558 |
|
Identification of the sequence responsible for the nuclear localization of human Cdc6. |
Takei Y, Yamamoto K, Tsujimoto G |
FEBS letters. 1999 ; 447 (2-3) : 292-296. |
PMID 10214964 |
|
A p53-dependent checkpoint pathway prevents rereplication. |
Vaziri C, Saxena S, Jeon Y, Lee C, Murata K, Machida Y, Wagle N, Hwang DS, Dutta A |
Molecular cell. 2003 ; 11 (4) : 997-1008. |
PMID 12718885 |
|
A human protein related to yeast Cdc6p. |
Williams RS, Shohet RV, Stillman B |
Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (1) : 142-147. |
PMID 8990175 |
|
Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. |
Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS |
Proceedings of the National Academy of Sciences of the United States of America. 1998 ; 95 (7) : 3603-3608. |
PMID 9520412 |
|
Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells. |
Yim H, Hwang IS, Choi JS, Chun KH, Jin YH, Ham YM, Lee KY, Lee SK |
The Journal of cell biology. 2006 ; 174 (1) : 77-88. |
PMID 16801388 |
|