Atlas of Genetics and Cytogenetics in Oncology and Haematology
EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2)
| Identity |
| Other names | DDX2B |
| HGNC (Hugo) | EIF4A2 |
| LocusID (NCBI) | 1974 |
| Location | 3q28 |
| Location_base_pair | Starts at 186501361 and ends at 186507685 bp from pter ( according to hg19-Feb_2009) [Mapping] |
 | |
| Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics | |
| DNA/RNA |
| Transcription | 1.9 kb mRNA; 1223 bp coding sequence |
| Protein |
| Description | 407 amino acids; 4.6 kDa; NH2-term, ATP binding site, DEAD box, COOH-term |
| Expression | wide; also expressed in the embryo |
| Function | ADP/ATP binding; RNA helicase; binds mRNA to the ribosome: role in initiation of protein synthesis; also -binds single strand DNA |
| Homology | DEAD box proteins, in particular other EIF4A |
| Implicated in |
| Entity | t(3;18)(q27;p11.2) --> EIF4A2/ BCL6 |
| Disease | non-Hodgkin lymphoma |
| Prognosis | yet unknown (only 1case available) |
| Hybrid/Mutated Gene | 5' EIF4A2 - 3' BCL6; EIF4A2 fuses with the second exon of BCL6 |
| Abnormal Protein | no fusion protein, but promoter exchange |
| Oncogenesis | BCL6 is a transcription repressor; it is supposed that substitution of the promoter of BCL6 may be responsible for BCL6 deregulation |
| External links |
| Bibliography |
| Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. |
| Sudo K, Takahashi E, Nakamura Y |
| Cytogenetics and cell genetics. 1995 ; 71 (4) : 385-388. |
| PMID 8521730 |
| The DEAD box protein eIF4A. 2. A cycle of nucleotide and RNA-dependent conformational changes. |
| Lorsch JR, Herschlag D |
| Biochemistry. 1998 ; 37 (8) : 2194-2206. |
| PMID 9485365 |
| Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. |
| Li Q, Imataka H, Morino S, Rogers GW Jr, Richter-Cook NJ, Merrick WC, Sonenberg N |
| Molecular and cellular biology. 1999 ; 19 (11) : 7336-7346. |
| PMID 10523622 |
| Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples. |
| Yoshida S, Kaneita Y, Aoki Y, Seto M, Mori S, Moriyama M |
| Oncogene. 1999 ; 18 (56) : 7994-7999. |
| PMID 10637510 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 07-2000 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2). Atlas Genet Cytogenet Oncol Haematol. July 2000 . URL : http://AtlasGeneticsOncology.org/Genes/EIF4A2ID262.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/2042/37635/1/07-2000-EIF4A2ID262.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Apr 28 15:06:30 CEST 2012 |
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