EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2)

Identity

Other names	DDX2B
Hugo	EIF4A2
Location	3q28

DNA/RNA

Transcription

1.9 kb mRNA; 1223 bp coding sequence

Protein

Description	407 amino acids; 4.6 kDa; NH2-term, ATP binding site, DEAD box, COOH-term
Expression	wide; also expressed in the embryo
Function	ADP/ATP binding; RNA helicase; binds mRNA to the ribosome: role in initiation of protein synthesis; also -binds single strand DNA
Homology	DEAD box proteins, in particular other EIF4A

Implicated in

Entity	t(3;18)(q27;p11.2) --> EIF4A2/ BCL6
Disease	non-Hodgkin lymphoma
Prognosis	yet unknown (only 1case available)
Hybrid/Mutated Gene	5' EIF4A2 - 3' BCL6; EIF4A2 fuses with the second exon of BCL6
Abnormal Protein	no fusion protein, but promoter exchange
Oncogenesis	BCL6 is a transcription repressor; it is supposed that substitution of the promoter of BCL6 may be responsible for BCL6 deregulation

External links

	Nomenclature
Hugo	EIF4A2
GDB	EIF4A2
Entrez_Gene	EIF4A2  1974  eukaryotic translation initiation factor 4A, isoform 2
	Cards
Atlas	EIF4A2ID262
GeneCards	EIF4A2
Ensembl	EIF4A2 [Search_View]   ENSG00000156976 [Gene_View]
Genatlas	EIF4A2
GeneLynx	EIF4A2
eGenome	EIF4A2
euGene	1974
	Genomic and cartography
GoldenPath	EIF4A2  -  3q28   chr3:187984055-187990377 +  3q28   [Description]    (hg18-Mar_2006)
Ensembl	EIF4A2 - 3q28 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	EIF4A2
	Gene and transcription
Genbank	AB209021 [ ENTREZ ]
Genbank	AF208852 [ ENTREZ ]
Genbank	AK130087 [ ENTREZ ]
Genbank	AK225646 [ ENTREZ ]
Genbank	AL117412 [ ENTREZ ]
RefSeq	NM_001967 [ SRS ]    NM_001967 [ ENTREZ ]
RefSeq	AC_000046 [ SRS ]    AC_000046 [ ENTREZ ]
RefSeq	NC_000003 [ SRS ]    NC_000003 [ ENTREZ ]
RefSeq	NT_005612 [ SRS ]    NT_005612 [ ENTREZ ]
RefSeq	NW_921807 [ SRS ]    NW_921807 [ ENTREZ ]
AceView	EIF4A2 AceView - NCBI
Unigene	Hs.700566 [ SRS ]    Hs.700566 [ NCBI ]     HS700566 [ spliceNest ]
Fast-db	15432 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q14240 [ SRS]    Q14240 [ EXPASY ]     Q14240 [ INTERPRO ]
Prosite	PS00039 DEAD_ATP_HELICASE [ SRS ]    PS00039 DEAD_ATP_HELICASE [ Expasy ]
Prosite	PS51192 HELICASE_ATP_BIND_1 [ SRS ]    PS51192 HELICASE_ATP_BIND_1 [ Expasy ]
Prosite	PS51194 HELICASE_CTER [ SRS ]    PS51194 HELICASE_CTER [ Expasy ]
Prosite	PS51195 Q_MOTIF [ SRS ]    PS51195 Q_MOTIF [ Expasy ]
Interpro	IPR014001 DEAD-like_N [ SRS ]    IPR014001 DEAD-like_N [ EBI ]
Interpro	IPR001650 DNA/RNA_helicase_C [ SRS ]    IPR001650 DNA/RNA_helicase_C [ EBI ]
Interpro	IPR011545 DNA/RNA_helicase_DEAD/DEAH_N [ SRS ]    IPR011545 DNA/RNA_helicase_DEAD/DEAH_N [ EBI ]
Interpro	IPR014021 Helicase_SF1/SF2_ATP-bd [ SRS ]    IPR014021 Helicase_SF1/SF2_ATP-bd [ EBI ]
Interpro	IPR000629 RNA-helicase_DEAD-box_CS [ SRS ]    IPR000629 RNA-helicase_DEAD-box_CS [ EBI ]
Interpro	IPR014014 RNA_helicase_DEAD_Q_motif [ SRS ]    IPR014014 RNA_helicase_DEAD_Q_motif [ EBI ]
CluSTr	Q14240
Pfam	PF00270 DEAD [ SRS ]    PF00270 DEAD [ Sanger ]    pfam00270 [ NCBI-CDD ]
Pfam	PF00271 Helicase_C [ SRS ]    PF00271 Helicase_C [ Sanger ]    pfam00271 [ NCBI-CDD ]
Smart	SM00487 DEXDc [EMBL]
Smart	SM00490 HELICc [EMBL]
Blocks	Q14240
HPRD	03062
	Protein Interaction databases
DIP	Q14240
IntAct	Q14240
	Polymorphism : SNP, mutations, diseases
OMIM	601102    [ map ]
GENECLINICS	601102
SNP	EIF4A2 [dbSNP-NCBI]
SNP	NM_001967 [SNP-NCI]
SNP	EIF4A2 [GeneSNPs - Utah]  EIF4A2] [HGBASE - SRS]
HAPMAP	EIF4A2 [HAPMAP]
COSMIC	EIF4A2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	EIF4A2
	General knowledge
Family Browser	EIF4A2 [UCSC Family Browser]
SOURCE	NM_001967
SMD	Hs.700566
SAGE	Hs.700566
Enzyme	3.6.1.- [ Enzyme-SRS ]   3.6.1.- [ Brenda-SRS ]   3.6.1.- [ KEGG ]   3.6.1.- [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	nucleic acid binding [Amigo]  nucleic acid binding
GO	RNA binding [Amigo]  RNA binding
GO	translation initiation factor activity [Amigo]  translation initiation factor activity
GO	translation initiation factor activity [Amigo]  translation initiation factor activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	translation [Amigo]  translation
GO	regulation of translational initiation [Amigo]  regulation of translational initiation
GO	ATP-dependent helicase activity [Amigo]  ATP-dependent helicase activity
GO	eukaryotic translation initiation factor 4F complex [Amigo]  eukaryotic translation initiation factor 4F complex
GO	hydrolase activity [Amigo]  hydrolase activity
PubGene	EIF4A2
TreeFam	EIF4A2
CTD	1974 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	EIF4A2 Related clones (RZPD - Berlin)
	PubMed
PubMed	11 Pubmed reference(s) in LocusLink

Bibliography

Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2.

Sudo K, Takahashi E, Nakamura Y

Cytogenetics and cell genetics. 1995 ; 71 (4) : 385-388.

PMID 8521730

The DEAD box protein eIF4A. 2. A cycle of nucleotide and RNA-dependent conformational changes.

Lorsch JR, Herschlag D

Biochemistry. 1998 ; 37 (8) : 2194-2206.

PMID 9485365

Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII.

Li Q, Imataka H, Morino S, Rogers GW Jr, Richter-Cook NJ, Merrick WC, Sonenberg N

Molecular and cellular biology. 1999 ; 19 (11) : 7336-7346.

PMID 10523622

Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples.

Yoshida S, Kaneita Y, Aoki Y, Seto M, Mori S, Moriyama M

Oncogene. 1999 ; 18 (56) : 7994-7999.

PMID 10637510

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	07-2000	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2). Atlas Genet Cytogenet Oncol Haematol. July 2000 . URL : http://AtlasGeneticsOncology.org/Genes/EIF4A2ID262.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Jul 2 08:23:15 2008