| Written | 2000-07 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
| Identity |
| Alias_names | EIF4F |
| eukaryotic translation initiation factor 4A | |
| Alias_symbol (synonym) | DDX2B |
| EIF4A | |
| BM-010 | |
| Other alias | |
| HGNC (Hugo) | EIF4A2 |
| LocusID (NCBI) | 1974 |
| Atlas_Id | 262 |
| Location | 3q27.3 [Link to chromosome band 3q27] |
| Location_base_pair | Starts at 186783572 and ends at 186789896 bp from pter ( according to hg19-Feb_2009) [Mapping EIF4A2.png] |
 | |
| Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics | |
| Fusion genes (updated 2016) | ACTR2 (2p14) / EIF4A2 (3q27.3) | ATP6V1C2 (2p25.1) / EIF4A2 (3q27.3) | BCL6 (3q27.3) / EIF4A2 (3q27.3) |
| CTSB (8p23.1) / EIF4A2 (3q27.3) | DLG5 (10q22.3) / EIF4A2 (3q27.3) | EIF4A2 (3q27.3) / BCL6 (3q27.3) | |
| EIF4A2 (3q27.3) / EIF4A2 (3q27.3) | EIF4A2 (3q27.3) / FUS (16p11.2) | EIF4A2 (3q27.3) / LMNA (1q22) | |
| EIF4A2 (3q27.3) / PPDPF (20q13.33) | EIF4A2 (3q27.3) / TGFBI (5q31.1) | KIAA1217 (10p12.2) / EIF4A2 (3q27.3) | |
| NOM1 (7q36.3) / EIF4A2 (3q27.3) |
| DNA/RNA |
| Transcription | 1.9 kb mRNA; 1223 bp coding sequence |
| Protein |
| Description | 407 amino acids; 4.6 kDa; NH2-term, ATP binding site, DEAD box, COOH-term |
| Expression | wide; also expressed in the embryo |
| Function | ADP/ATP binding; RNA helicase; binds mRNA to the ribosome: role in initiation of protein synthesis; also -binds single strand DNA |
| Homology | DEAD box proteins, in particular other EIF4A |
| Implicated in |
| Note | |
| Entity | t(3;18)(q27;p11.2) --> EIF4A2/ BCL6 |
| Disease | non-Hodgkin lymphoma |
| Prognosis | yet unknown (only 1case available) |
| Hybrid/Mutated Gene | 5' EIF4A2 - 3' BCL6; EIF4A2 fuses with the second exon of BCL6 |
| Abnormal Protein | no fusion protein, but promoter exchange |
| Oncogenesis | BCL6 is a transcription repressor; it is supposed that substitution of the promoter of BCL6 may be responsible for BCL6 deregulation |
| Bibliography |
| Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. |
| Li Q, Imataka H, Morino S, Rogers GW Jr, Richter-Cook NJ, Merrick WC, Sonenberg N |
| Molecular and cellular biology. 1999 ; 19 (11) : 7336-7346. |
| PMID 10523622 |
| The DEAD box protein eIF4A. 2. A cycle of nucleotide and RNA-dependent conformational changes. |
| Lorsch JR, Herschlag D |
| Biochemistry. 1998 ; 37 (8) : 2194-2206. |
| PMID 9485365 |
| Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. |
| Sudo K, Takahashi E, Nakamura Y |
| Cytogenetics and cell genetics. 1995 ; 71 (4) : 385-388. |
| PMID 8521730 |
| Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples. |
| Yoshida S, Kaneita Y, Aoki Y, Seto M, Mori S, Moriyama M |
| Oncogene. 1999 ; 18 (56) : 7994-7999. |
| PMID 10637510 |
| Citation |
| This paper should be referenced as such : |
| Huret, JL |
| EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2) |
| Atlas Genet Cytogenet Oncol Haematol. 2000;4(3):105-106. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Genes/EIF4A2ID262.html |
| Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ] |
|
3q27 rearrangements (BCL6) in non Hodgkin lymphoma::t(3;Var)(q27;Var) in non Hodgkin lymphoma
t(3;3)(q27;q28) EIF4A2/BCL6 |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Sep 18 17:01:54 CEST 2017 |
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