Written | 2000-07 | Jean-Loup Huret |
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
Identity |
Alias_names | EIF4F |
eukaryotic translation initiation factor 4A, isoform 2 | |
Alias_symbol (synonym) | DDX2B |
EIF4A | |
BM-010 | |
Other alias | |
HGNC (Hugo) | EIF4A2 |
LocusID (NCBI) | 1974 |
Atlas_Id | 262 |
Location | 3q27.3 [Link to chromosome band 3q27] |
Location_base_pair | Starts at 186783572 and ends at 186789896 bp from pter ( according to hg19-Feb_2009) [Mapping EIF4A2.png] |
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Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics | |
Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
ACTR2 (2p14) / EIF4A2 (3q27.3) | ATP6V1C2 (2p25.1) / EIF4A2 (3q27.3) | BCL6 (3q27.3) / EIF4A2 (3q27.3) | |
CTSB (8p23.1) / EIF4A2 (3q27.3) | DLG5 (10q22.3) / EIF4A2 (3q27.3) | EIF4A2 (3q27.3) / BCL6 (3q27.3) | |
EIF4A2 (3q27.3) / EIF4A2 (3q27.3) | EIF4A2 (3q27.3) / FUS (16p11.2) | EIF4A2 (3q27.3) / LMNA (1q22) | |
EIF4A2 (3q27.3) / PPDPF (20q13.33) | EIF4A2 (3q27.3) / TGFBI (5q31.1) | KIAA1217 (10p12.2) / EIF4A2 (3q27.3) | |
NOM1 (7q36.3) / EIF4A2 (3q27.3) |
DNA/RNA |
Transcription | 1.9 kb mRNA; 1223 bp coding sequence |
Protein |
Description | 407 amino acids; 4.6 kDa; NH2-term, ATP binding site, DEAD box, COOH-term |
Expression | wide; also expressed in the embryo |
Function | ADP/ATP binding; RNA helicase; binds mRNA to the ribosome: role in initiation of protein synthesis; also -binds single strand DNA |
Homology | DEAD box proteins, in particular other EIF4A |
Implicated in |
Note | |
Entity | t(3;18)(q27;p11.2) --> EIF4A2/ BCL6 |
Disease | non-Hodgkin lymphoma |
Prognosis | yet unknown (only 1case available) |
Hybrid/Mutated Gene | 5' EIF4A2 - 3' BCL6; EIF4A2 fuses with the second exon of BCL6 |
Abnormal Protein | no fusion protein, but promoter exchange |
Oncogenesis | BCL6 is a transcription repressor; it is supposed that substitution of the promoter of BCL6 may be responsible for BCL6 deregulation |
Bibliography |
Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. |
Li Q, Imataka H, Morino S, Rogers GW Jr, Richter-Cook NJ, Merrick WC, Sonenberg N |
Molecular and cellular biology. 1999 ; 19 (11) : 7336-7346. |
PMID 10523622 |
The DEAD box protein eIF4A. 2. A cycle of nucleotide and RNA-dependent conformational changes. |
Lorsch JR, Herschlag D |
Biochemistry. 1998 ; 37 (8) : 2194-2206. |
PMID 9485365 |
Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. |
Sudo K, Takahashi E, Nakamura Y |
Cytogenetics and cell genetics. 1995 ; 71 (4) : 385-388. |
PMID 8521730 |
Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples. |
Yoshida S, Kaneita Y, Aoki Y, Seto M, Mori S, Moriyama M |
Oncogene. 1999 ; 18 (56) : 7994-7999. |
PMID 10637510 |
Citation |
This paper should be referenced as such : |
Huret, JL |
EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2) |
Atlas Genet Cytogenet Oncol Haematol. 2000;4(3):105-106. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Genes/EIF4A2ID262.html |
Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ] |
t(3;3)(q27;q28) EIF4A2/BCL6
|
Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ] |
t(3;8)(q27;p23) CTSB/EIF4A2
|
External links |
REVIEW articles | automatic search in PubMed |
Last year publications | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Nov 13 21:17:29 CET 2019 |
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