EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2)
2000-07-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
3q27.3
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
BM-010,DDX2B,EIF4A,EIF4F,eIF-4A-II,eIF4A-II
FUSION GENES
DNA/RNA
Transcription
1.9 kb mRNA; 1223 bp coding sequence
Proteins
Description
407 amino acids; 4.6 kDa; NH2-term, ATP binding site, DEAD box, COOH-term
Expression
wide; also expressed in the embryo
Function
ADP/ATP binding; RNA helicase; binds mRNA to the ribosome: role in initiation of protein synthesis; also -binds single strand DNA
Homology
DEAD box proteins, in particular other EIF4A
Implicated in
Entity name
Disease
non-Hodgkin lymphoma
Prognosis
yet unknown (only 1case available)
Hybrid gene
5 EIF4A2 - 3 BCL6; EIF4A2 fuses with the second exon of BCL6
Fusion protein
no fusion protein, but promoter exchange
Oncogenesis
BCL6 is a transcription repressor; it is supposed that substitution of the promoter of BCL6 may be responsible for BCL6 deregulation
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10523622 | 1999 | Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. | Li Q et al |
| 9485365 | 1998 | The DEAD box protein eIF4A. 2. A cycle of nucleotide and RNA-dependent conformational changes. | Lorsch JR et al |
| 8521730 | 1995 | Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. | Sudo K et al |
| 10637510 | 1999 | Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples. | Yoshida S et al |
Other Information
Locus ID:
NCBI: 1974
MIM: 601102
HGNC: 3284
Ensembl: ENSG00000156976
Variants:
dbSNP: 1974
ClinVar: 1974
TCGA: ENSG00000156976
COSMIC: EIF4A2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36528028 | 2023 | Rare EIF4A2 variants are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy. | 2 |
| 37331603 | 2023 | Monitoring RNA restructuring in a human cell-free extract reveals eIF4A-dependent and eIF4A-independent unwinding activity. | 2 |
| 37485550 | 2023 | Dystonia Linked to EIF4A2 Haploinsufficiency: A Disorder of Protein Translation Dysfunction. | 2 |
| 36528028 | 2023 | Rare EIF4A2 variants are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy. | 2 |
| 37331603 | 2023 | Monitoring RNA restructuring in a human cell-free extract reveals eIF4A-dependent and eIF4A-independent unwinding activity. | 2 |
| 37485550 | 2023 | Dystonia Linked to EIF4A2 Haploinsufficiency: A Disorder of Protein Translation Dysfunction. | 2 |
| 31088567 | 2019 | Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer. | 31 |
| 31180491 | 2019 | DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity. | 14 |
| 31308851 | 2019 | MicroRNA-5195-3p enhances the chemosensitivity of triple-negative breast cancer to paclitaxel by downregulating EIF4A2. | 28 |
| 31791371 | 2019 | eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR. | 29 |
| 31088567 | 2019 | Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer. | 31 |
| 31180491 | 2019 | DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity. | 14 |
| 31308851 | 2019 | MicroRNA-5195-3p enhances the chemosensitivity of triple-negative breast cancer to paclitaxel by downregulating EIF4A2. | 28 |
| 31791371 | 2019 | eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR. | 29 |
| 29842983 | 2018 | eIF4A2 is a host factor required for efficient HIV-1 replication. | 13 |
Citation
Jean-Loup Huret
EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2)
Atlas Genet Cytogenet Oncol Haematol. 2000-07-01
Online version: http://atlasgeneticsoncology.org/gene/262/eif4a2
