DNA size 27.75 kb; mRNA size 2021 bp; 12 exons.

425 amino acids; 47.82 kDa protein.

Post translational modifications: Phosphorylation enhances DNA binding. Phosphorylation occurs at position 95, 99, 354, 413 (Serine) and 416 (Threonine). Acetylation brings in a negative charge, acting to neutralise the positive charge on the histones and decreases the interaction of the N termini of histones with the negatively charged phosphate groups of DNA. As a consequence, the condensed chromatin is transformed into a more relaxed structure which is associated with greater levels of gene transcription.
The acetylation sites are: at 2 (Alanine), and 119 (Lysine).

Isoform: The following isoforms have been identified:
- RBBP7.iApr07
- hPA25320.1 (469 aa)
- hPA25320.2 (425 aa)
- hPA25320.3 (410 aa)
- hPA25320.7 (420 aa)

It is widely expressed.

Nucleus.

This protein is an ubiquitously expressed nuclear protein and it belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly, which include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodelling. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.

The percent identity below represents identity of RBBP7 over an aligned region in UniGene.
- M. musculus : 100 (percentage identity)
- C. lupus familiaris : 100
- B. taurus : 100
- R. norvegicus : 100
- G.gallus : 96.2
- D. rerio : 94.4

Two types of mutation have been detected in the RBBP7 gene. A827G is a silent mutation and the other one is a missense type of mutation that changes N276S.