Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TBX2 (T-box 2)

Written2005-07Ayse Elif Erson, Elizabeth M. Petty
Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA (EMP)

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)FLJ10169
HGNC (Hugo) TBX2
HGNC Previous nameT-box 2
LocusID (NCBI) 6909
Atlas_Id 42485
Location 17q23.2  [Link to chromosome band 17q23]
Location_base_pair Starts at 61399843 and ends at 61409466 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping TBX2.png]
Local_order Genes flanking TBX2 in centromere to telomere direction on 17q23 are:
APPBP2, 17q21-q23, amyloid beta precursor protein (cytoplasmic tail) binding protein 2
TBX2, 17q23, T-box2
PPM1D, 17q23, protein phosphatase 1D magnesium-dependent, delta isoform
LOC440450, 17q23.2 LOC440450
LOC388407, 17q23.2, hypothetical gene supported by BC046200
LOC388406, 17q23.2, hypothetical LOC388406
MGC71999, 17q23.2, alpha-NAC protein
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CPD (17q11.2) / TBX2 (17q23.2)
Note T-box proteins contain a T-domain that has roles in dimerization and DNA binding. TBX2 belongs to the Tbx2 subfamily of T-box transcription factors. Other subfamilies of T-box genes are Brachyury, T-brain1, Tbx1 and Tbx6. TBX2, TBX3, TBX4 and TBX5 belong to the Tbx2 subfamily. TBX2 and TBX3 are the only mammalian T-box factors with reported transcriptional repressor functions.

DNA/RNA

Note Genes of the same T-box subfamily are thought to have arisen from duplication and recombination of a single ancestor gene. TBX2 is most closely related to TBX3 (12q24), whereas the other members of the subfamily, TBX4 and TBX5, are more closely related to one another. It is postulated that genes of the same subfamily may have redundant expression patterns and thus potential functional redundancy.
 
  The alignment of TBX2 mRNA (3396 bp) to its genomic sequence.
Description TBX2 gene spans 9,5kb. TBX2 gene has 7 exons and the sizes of the exons 1 to 7 are 676, 268, 147, 77, 164, 635, 1413 bps. Exon/intron boundaries of TBX2 and a polymorphism within intron 2 of the gene have also been reported.
Transcription TBX2 mRNA is 3396 bp. TBX2 mRNA is expressed in a wide variety of tissues including fetal kidney and fetal lung as well as multiple adult tissues, kidney, lung, placenta, ovary, prostate, spleen, testis and breast. Relatively reduced expression of TBX2 can be detected in heart, white blood cells, small intestine and thymus. Transcript size heterogeneity has been detected for TBX2, possibly due to alternative polyadenylation.
Increased TBX2 mRNA is observed within 2 hours after addition of retinoic acid in B16 mouse melanoma cells due to the presence of a degenerate retinoic acid response element (RARE) between -186 and -163 in the promoter region of the TBX2 gene.

Transcript localisation: Human and mouse TBX2, TBX3, and TBX5 transcripts detected by riboprobes are found asymmetrically across the embryonic neural retina, with highest levels of transcripts within dorsal and peripheral retina. The dorsoventral gradient of TBX2 expression cannot be detected before the ganglion cell layer (GCL) forms and expression is found to be restricted to the inner neuroblastic retina and later to the GCL and inner nuclear layer.
TBX2 transcript is also detected in the optic and otic vesicles at 9.5 dpc, and in the naso-facial mesenchyme, and later in the developing limbs and other internal organ primordia (of lungs and genitalia).
Later at around 8 and 10 dpc, TBX2 is detected in allantois, inflow tract (IFT), outflow tract (OFT) and atrio-ventricular canal (AVC) of the developing mouse heart. Chick heart development is also consistent in terms of similar TBX2 expression patterns.
During mammary development, TBX2 expression is detected at 11.5 dpc in the mesodermal milk lines.

Pseudogene No pseudogenes have been reported for TBX2.

Protein

Description Protein consists of 702 amino acids and is 74.2 kDa. Protein has the T-box DNA binding domain (corresponds to amino acids 96-279) of the T-box family of transcriptional regulators.
Function In an evolutionarily diverse group of organisms including chick, Xenopus, mouse, and human, TBX2 is involved during development of widely diverse organs and tissues including limbs, kidneys, lungs, mammary glands, heart and craniofacial structures.
In order to identify genes that may be regulated by Tbx2, mouse cDNA microarrays were used to analyze differential gene expression profiles, comparing stably transfected NIH3T3 cells overexpressing Tbx2 with vector-transfected controls. 107 genes were up-regulated (more than or equal to 2-fold) and 66 genes were down-regulated (more than or equal to 2-fold). Among the upregulated genes in the Tbx2-overexpressing cells were: Caveolin, Pleiotrophin, Osteoblast-specific factor-2 and Collagen Type I alpha. Cadherin 3, Tenascin C, and Insulin-like Growth Factor Binding Protein 10/CYR61 (IBP10) were among the genes that are downregulated.
In vitro reporter assays and transgenic mice studies suggest that TBX2 represses the transcription of certain cardiac genes (e.g. Connexin 40, Connexin 43, and Natriuretic Peptide Precursor A) during heart development. TBX2 and TBX3 are also thought to be regulating one another in Hedgehog related signaling pathways during chick limb development.
In addition to developmental functions, evidence suggest that TBX2 also has important roles in cell cycle regulation through repressing the expression of CDKN1A (p21, cyclin-dependent kinase inhibitor) and CDKN2A (p19ARF). In BMI oncogene deficient murine embryonic fibroblasts, TBX2 is shown to repress the CDKN2A promoter and also attenuate the induction of CDKN2A by E2F1, MYC, and HRAS, providing senescence bypass and suggesting TBX2 as a potent immortalizing gene.
Homology C.familiaris: Tbx2, T-box 2 transcription factor
M.musculus: Tbx2, T-box 2
R.norvegicus: Tbx2_predicted, T-box 2 (predicted)
D.melanogaster: bi, bifid
A.gambiae: 1280927, Anopheles gambiae str. PEST ENSANGG00000011542 gene.
C.elegans: tbx-2, T-box family member (47.0 kD)

Mutations

Germinal Despite the high frequency T-box family gene mutations identified as causes of congenital developmental disorders, there have been no mutations reported for TBX2 that cause congenital anomalies. Germline segregation of TBX2 mutations with human diseases has not been identified.
Somatic CGH (comparative genomic hybridization), Southern blot, FISH, PCR based techniques and microarray analyses suggest amplification and overexpression of TBX2 in certain cancer cells.

Implicated in

Note
  
  
Entity Breast cancer
Note TBX2 has been found to be amplified and overexpressed in breast cancer cell lines and primary tumors. TBX2 resides on the chromosomal band 17q23 that is frequently amplified in breast cancer cells. Evidence suggests presence of distinct proximal and distal amplicons on 17q23 with defined boundaries. TBX2 seems to be at the center of the distal amplicon. In addition to breast cancer cell line data, a study of tissue microarray of 372 primary tumors found TBX2 amplification in 8.6% of the cases. Moreover, preferential amplification and overexpression of TBX2 have been detected in BRCA1 and BRCA2 mutated breast tumors compared to sporadic controls.
  
  
Entity Pancreatic Cancer
Note TBX2 amplification has been detected in 50% of 20 pancreatic cancer cell lines detected by interphase FISH.
  
  
Entity Melanomas
Note TBX2 overexpression in melanoma cell lines is thought to target histone deacetylase 1 to the CDKN1A initiator. Expression of a dominant-negative Tbx2 leads to displacement of histone deacetylase 1 with up-regulation of CDKN1A expression, and the induction of replicative senescence in CDKN2A-null B16 melanoma cells. In human melanoma cells, expression of the same dominant negative TBX2 results with reduced growth and induction of senescence-associated heterochromatin foci.
  
Note Analysis of TBX2 in other tumor types has not been widely reported.
  

Bibliography

Multiple genes at 17q23 undergo amplification and overexpression in breast cancer.
Bärlund M, Monni O, Kononen J, Cornelison R, Torhorst J, Sauter G, Kallioniemi OLLI-P, Kallioniemi A
Cancer research. 2000 ; 60 (19) : 5340-5344.
PMID 11034067
 
Tension-induced reduction in connexin 43 expression in cranial sutures is linked to transcriptional regulation by TBX2.
Borke JL, Yu JC, Isales CM, Wagle N, Do NN, Chen JR, Bollag RJ
Annals of plastic surgery. 2003 ; 51 (5) : 499-504.
PMID 14595187
 
T-box binding protein type two (TBX2) is an immediate early gene target in retinoic-acid-treated B16 murine melanoma cells.
Boskovic G, Niles RM
Experimental cell research. 2004 ; 295 (2) : 281-289.
PMID 15093729
 
Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene.
Campbell C, Goodrich K, Casey G, Beatty B
Genomics. 1995 ; 28 (2) : 255-260.
PMID 8530034
 
Genomic structure of TBX2 indicates conservation with distantly related T-box genes.
Campbell CE, Casey G, Goodrich K
Mammalian genome : official journal of the International Mammalian Genome Society. 1998 ; 9 (1) : 70-73.
PMID 9434949
 
Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development.
Chapman DL, Garvey N, Hancock S, Alexiou M, Agulnik SI, Gibson-Brown JJ, Cebra-Thomas J, Bollag RJ, Silver LM, Papaioannou VE
Developmental dynamics : an official publication of the American Association of Anatomists. 1996 ; 206 (4) : 379-390.
PMID 8853987
 
Microarray analysis of Tbx2-directed gene expression: a possible role in osteogenesis.
Chen J, Zhong Q, Wang J, Cameron RS, Borke JL, Isales CM, Bollag RJ
Molecular and cellular endocrinology. 2001 ; 177 (1-2) : 43-54.
PMID 11377819
 
Tbx2 represses expression of Connexin43 in osteoblastic-like cells.
Chen JR, Chatterjee B, Meyer R, Yu JC, Borke JL, Isales CM, Kirby ML, Lo CW, Bollag RJ
Calcified tissue international. 2004 ; 74 (6) : 561-573.
PMID 15354864
 
T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers.
Christoffels VM, Hoogaars WM, Tessari A, Clout DE, Moorman AF, Campione M
Developmental dynamics : an official publication of the American Association of Anatomists. 2004 ; 229 (4) : 763-770.
PMID 15042700
 
Overexpressed genes/ESTs and characterization of distinct amplicons on 17q23 in breast cancer cells.
Erson AE, Niell BL, DeMers SK, Rouillard JM, Hanash SM, Petty EM
Neoplasia (New York, N.Y.). 2001 ; 3 (6) : 521-526.
PMID 11774034
 
Expression of T-box genes Tbx2-Tbx5 during chick organogenesis.
Gibson-Brown JJ, I Agulnik S, Silver LM, Papaioannou VE
Mechanisms of development. 1998 ; 74 (1-2) : 165-169.
PMID 9651516
 
Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation.
Habets PE, Moorman AF, Clout DE, van Roon MA, Lingbeek M, van Lohuizen M, Campione M, Christoffels VM
Genes & development. 2002 ; 16 (10) : 1234-1246.
PMID 12023302
 
Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family.
Law DJ, Gebuhr T, Garvey N, Agulnik SI, Silver LM
Mammalian genome : official journal of the International Mammalian Genome Society. 1995 ; 6 (11) : 793-797.
PMID 8597636
 
Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer.
Mahlamäki EH, Bärlund M, Tanner M, Gorunova L, Höglund M, Karhu R, Kallioniemi A
Genes, chromosomes & cancer. 2002 ; 35 (4) : 353-358.
PMID 12378529
 
T-box genes in human disorders.
Packham EA, Brook JD
Human molecular genetics. 2003 ; 12 Spec No 1 : R37-R44.
PMID 12668595
 
T-box genes and heart development: putting the T in heart.
Plageman TF Jr, Yutzey KE
Developmental dynamics : an official publication of the American Association of Anatomists. 2005 ; 232 (1) : 11-20.
PMID 15580613
 
Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor.
Prince S, Carreira S, Vance KW, Abrahams A, Goding CR
Cancer research. 2004 ; 64 (5) : 1669-1674.
PMID 14996726
 
Virtual genome scan: a tool for restriction landmark-based scanning of the human genome.
Rouillard JM, Erson AE, Kuick R, Asakawa J, Wimmer K, Muleris M, Petty EM, Hanash S
Genome research. 2001 ; 11 (8) : 1453-1459.
PMID 11483587
 
The role of Tbx2 and Tbx3 in mammary development and tumorigenesis.
Rowley M, Grothey E, Couch FJ
Journal of mammary gland biology and neoplasia. 2004 ; 9 (2) : 109-118.
PMID 15300007
 
TBX2 is preferentially amplified in BRCA1- and BRCA2-related breast tumors.
Sinclair CS, Adem C, Naderi A, Soderberg CL, Johnson M, Wu K, Wadum L, Couch VL, Sellers TA, Schaid D, Slezak J, Fredericksen Z, Ingle JN, Hartmann L, Jenkins RB, Couch FJ
Cancer research. 2002 ; 62 (13) : 3587-3591.
PMID 12097257
 
Expression of Drosophila omb-related T-box genes in the developing human and mouse neural retina.
Sowden JC, Holt JK, Meins M, Smith HK, Bhattacharya SS
Investigative ophthalmology & visual science. 2001 ; 42 (13) : 3095-3102.
PMID 11726608
 
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.
Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP
Development (Cambridge, England). 2005 ; 132 (10) : 2451-2462.
PMID 15843414
 
Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling.
Suzuki T, Takeuchi J, Koshiba-Takeuchi K, Ogura T
Developmental cell. 2004 ; 6 (1) : 43-53.
PMID 14723846
 
Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas.
Vance KW, Carreira S, Brosch G, Goding CR
Cancer research. 2005 ; 65 (6) : 2260-2268.
PMID 15781639
 
The T-box family.
Wilson V, Conlon FL
Genome biology. 2002 ; 3 (6) : page REVIEWS3008.
PMID 12093383
 
Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2.
Yamada M, Revelli JP, Eichele G, Barron M, Schwartz RJ
Developmental biology. 2000 ; 228 (1) : 95-105.
PMID 11087629
 

Citation

This paper should be referenced as such :
Erson, AE ; Petty, EM
TBX2 (T-box 2)
Atlas Genet Cytogenet Oncol Haematol. 2005;9(4):300-302.
Free journal version : [ pdf ]   [ DOI ]

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(17;17)(q11;q23) CPD/TBX2

External links

Nomenclature
HGNC (Hugo)TBX2   11597
Cards
AtlasTBX2ID42485ch17q23
Entrez_Gene (NCBI)TBX2    T-box transcription factor 2
AliasesVETD
GeneCards (Weizmann)TBX2
Ensembl hg19 (Hinxton)ENSG00000121068 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121068 [Gene_View]  ENSG00000121068 [Sequence]  chr17:61399843-61409466 [Contig_View]  TBX2 [Vega]
ICGC DataPortalENSG00000121068
TCGA cBioPortalTBX2
AceView (NCBI)TBX2
Genatlas (Paris)TBX2
SOURCE (Princeton)TBX2
Genetics Home Reference (NIH)TBX2
Genomic and cartography
GoldenPath hg38 (UCSC)TBX2  -     chr17:61399843-61409466 +  17q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBX2  -     17q23.2   [Description]    (hg19-Feb_2009)
GoldenPathTBX2 - 17q23.2 [CytoView hg19]  TBX2 - 17q23.2 [CytoView hg38]
ImmunoBaseENSG00000121068
genome Data Viewer NCBITBX2 [Mapview hg19]  
OMIM600747   618223   
Gene and transcription
Genbank (Entrez)AB209378 AK001031 AK127429 AL832900 AW006595
RefSeq transcript (Entrez)NM_005994
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TBX2
Alternative Splicing GalleryENSG00000121068
Gene ExpressionTBX2 [ NCBI-GEO ]   TBX2 [ EBI - ARRAY_EXPRESS ]   TBX2 [ SEEK ]   TBX2 [ MEM ]
Gene Expression Viewer (FireBrowse)TBX2 [ Firebrowse - Broad ]
GenevisibleExpression of TBX2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6909
GTEX Portal (Tissue expression)TBX2
Human Protein AtlasENSG00000121068-TBX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13207   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13207  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13207
Splice isoforms : SwissVarQ13207
PhosPhoSitePlusQ13207
Domaine pattern : Prosite (Expaxy)TBOX_1 (PS01283)    TBOX_2 (PS01264)    TBOX_3 (PS50252)   
Domains : Interpro (EBI)p53-like_TF_DNA-bd    T-box_sf    TBX    TF_Brachyury    TF_T-box    TF_T-box_CS   
Domain families : Pfam (Sanger)T-box (PF00907)    TBX (PF12598)   
Domain families : Pfam (NCBI)pfam00907    pfam12598   
Domain families : Smart (EMBL)TBOX (SM00425)  
Conserved Domain (NCBI)TBX2
Blocks (Seattle)TBX2
SuperfamilyQ13207
Human Protein Atlas [tissue]ENSG00000121068-TBX2 [tissue]
Peptide AtlasQ13207
HPRD02850
IPIIPI00940256   IPI00555938   IPI00956369   IPI00925935   
Protein Interaction databases
DIP (DOE-UCLA)Q13207
IntAct (EBI)Q13207
BioGRIDTBX2
STRING (EMBL)TBX2
ZODIACTBX2
Ontologies - Pathways
QuickGOQ13207
Ontology : AmiGO"negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II activating transcription factor binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  cell fate specification  heart looping  outflow tract septum morphogenesis  outflow tract morphogenesis  endocardial cushion morphogenesis  regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  DNA binding  protein binding  nucleus  nucleus  transcription factor complex  Notch signaling pathway  muscle cell fate determination  cell aging  regulation of heart contraction  positive regulation of cell proliferation  embryonic heart tube development  aorta morphogenesis  atrioventricular canal development  embryonic digit morphogenesis  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  embryonic camera-type eye morphogenesis  cardiac muscle tissue development  roof of mouth development  positive regulation of cardiac muscle cell proliferation  pharynx development  developmental growth involved in morphogenesis  mammary placode formation  cellular senescence  negative regulation of heart looping  negative regulation of cardiac chamber formation"  
Ontology : EGO-EBI"negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II activating transcription factor binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  cell fate specification  heart looping  outflow tract septum morphogenesis  outflow tract morphogenesis  endocardial cushion morphogenesis  regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  DNA binding  protein binding  nucleus  nucleus  transcription factor complex  Notch signaling pathway  muscle cell fate determination  cell aging  regulation of heart contraction  positive regulation of cell proliferation  embryonic heart tube development  aorta morphogenesis  atrioventricular canal development  embryonic digit morphogenesis  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  embryonic camera-type eye morphogenesis  cardiac muscle tissue development  roof of mouth development  positive regulation of cardiac muscle cell proliferation  pharynx development  developmental growth involved in morphogenesis  mammary placode formation  cellular senescence  negative regulation of heart looping  negative regulation of cardiac chamber formation"  
NDEx NetworkTBX2
Atlas of Cancer Signalling NetworkTBX2
Wikipedia pathwaysTBX2
Orthology - Evolution
OrthoDB6909
GeneTree (enSembl)ENSG00000121068
Phylogenetic Trees/Animal Genes : TreeFamTBX2
HOGENOMQ13207
Homologs : HomoloGeneTBX2
Homology/Alignments : Family Browser (UCSC)TBX2
Gene fusions - Rearrangements
Fusion : MitelmanCPD/TBX2 [17q11.2/17q23.2]  
Fusion PortalCPD 17q11.2 TBX2 17q23.2 BRCA
Fusion : Fusion_HubCPD--TBX2    NAMPT--TBX2    TBX2--MYH11    TBX2--UBE2V1   
Fusion : QuiverTBX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBX2 [hg38]
dbVarTBX2
ClinVarTBX2
MonarchTBX2
1000_GenomesTBX2 
Exome Variant ServerTBX2
GNOMAD BrowserENSG00000121068
Varsome BrowserTBX2
Genomic Variants (DGV)TBX2 [DGVbeta]
DECIPHERTBX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBX2 
Mutations
ICGC Data PortalTBX2 
TCGA Data PortalTBX2 
Broad Tumor PortalTBX2
OASIS PortalTBX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBX2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTBX2
Mutations and Diseases : HGMDTBX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TBX2
DgiDB (Drug Gene Interaction Database)TBX2
DoCM (Curated mutations)TBX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TBX2 (select a term)
intoGenTBX2
NCG6 (London) select TBX2
Cancer3DTBX2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600747    618223   
Orphanet19868   
DisGeNETTBX2
MedgenTBX2
Genetic Testing Registry TBX2
NextProtQ13207 [Medical]
GENETestsTBX2
Target ValidationTBX2
Huge Navigator TBX2 [HugePedia]
ClinGenTBX2
Clinical trials, drugs, therapy
MyCancerGenomeTBX2
Protein Interactions : CTD
Pharm GKB GenePA36360
PharosQ13207
Clinical trialTBX2
Miscellaneous
canSAR (ICR)TBX2 (select the gene name)
HarmonizomeTBX2
DataMed IndexTBX2
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTBX2
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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