TCL1A (T-cell leukemia/lymphoma 1A)

Identity

Other names	TCL1 (T Cell Leukemia/Lymphoma 1)
Hugo	TCL1A
Location	14q32.1

DNA/RNA

Description	4 exons; telomere - exon 1 to 4 - centromere orientation
Transcription	1.3 kb transcripts

Protein

Description	114 amino acids; one domain with a b-barrel topology
Expression	immature T and B lymphoid cells
Localisation	cytoplasm
Function	unknown
Homology	MTCP1 (38 % identity, similar tridimentional structure)

Implicated in

Entity	t(14;14)(q12;q32.1) or inv(14)(q12q32.1) /T-cell malignancies --> TCRA/D - TCL1
Disease	mainly T-cell prolymphocytic leukemia (T-PLL); T- cell NHL; T-cell ALL
Cytogenetics	associated with i(8q) in T-PLL
Hybrid/Mutated Gene	none
Abnormal Protein	none
Oncogenesis	over expression of TCL1 is considered as critical in the oncogenetic mechanism
Entity	t(7;14)(q35;q32.1)/T-cell malignancies --> TCRB - TCL1
Disease	mainly T-cell prolymphocytic leukemia
Cytogenetics	associated with i(8q)
Hybrid/Mutated Gene	none
Abnormal Protein	none
Oncogenesis	over expression of TCL1

External links

	Nomenclature
Hugo	TCL1A
GDB	TCL1A
Entrez_Gene	TCL1A  8115  T-cell leukemia/lymphoma 1A
	Cards
Atlas	TCL1ID66
GeneCards	TCL1A
Ensembl	TCL1A [Search_View]   ENSG00000100721 [Gene_View]
Genatlas	TCL1A
GeneLynx	TCL1A
eGenome	TCL1A
euGene	8115
	Genomic and cartography
GoldenPath	TCL1A  -  14q32.1   chr14:95246057-95250286 -  14q32.1   [Description]    (hg18-Mar_2006)
Ensembl	TCL1A - 14q32.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TCL1A
	Gene and transcription
Genbank	BC003574 [ ENTREZ ]
Genbank	BC005831 [ ENTREZ ]
Genbank	BC009502 [ ENTREZ ]
Genbank	BC009891 [ ENTREZ ]
Genbank	BC014024 [ ENTREZ ]
RefSeq	NM_001098725 [ SRS ]    NM_001098725 [ ENTREZ ]
RefSeq	NM_021966 [ SRS ]    NM_021966 [ ENTREZ ]
RefSeq	AC_000057 [ SRS ]    AC_000057 [ ENTREZ ]
RefSeq	AC_000146 [ SRS ]    AC_000146 [ ENTREZ ]
RefSeq	NC_000014 [ SRS ]    NC_000014 [ ENTREZ ]
RefSeq	NT_026437 [ SRS ]    NT_026437 [ ENTREZ ]
RefSeq	NW_001838115 [ SRS ]    NW_001838115 [ ENTREZ ]
RefSeq	NW_925561 [ SRS ]    NW_925561 [ ENTREZ ]
AceView	TCL1A AceView - NCBI
Unigene	Hs.2484 [ SRS ]    Hs.2484 [ NCBI ]     HS2484 [ spliceNest ]
Fast-db	5451 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P56279 [ SRS]    P56279 [ EXPASY ]     P56279 [ INTERPRO ]
Interpro	IPR004832 TCL1_MTCP1 [ SRS ]    IPR004832 TCL1_MTCP1 [ EBI ]
CluSTr	P56279
Pfam	PF01840 TCL1_MTCP1 [ SRS ]    PF01840 TCL1_MTCP1 [ Sanger ]    pfam01840 [ NCBI-CDD ]
Prodom	PD015575 TCL1_MTCP1[INRA-Toulouse]
Prodom	P56279 TCL1A_HUMAN [ Domain structure ]   P56279 TCL1A_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P56279
PDB	TCL1A [ SRS ]    TCL1A [ PdbSum ],   TCL1A [ IMB ]   TCL1A [ RSDB ]
HPRD	01744
	Protein Interaction databases
DIP	P56279
IntAct	P56279
	Polymorphism : SNP, mutations, diseases
OMIM	186960    [ map ]
GENECLINICS	186960
SNP	TCL1A [dbSNP-NCBI]
SNP	NM_001098725 [SNP-NCI]
SNP	NM_021966 [SNP-NCI]
SNP	TCL1A [GeneSNPs - Utah]  TCL1A] [HGBASE - SRS]
HAPMAP	TCL1A [HAPMAP]
COSMIC	TCL1A [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TCL1A
	General knowledge
Family Browser	TCL1A [UCSC Family Browser]
SOURCE	NM_001098725
SOURCE	NM_021966
SMD	Hs.2484
SAGE	Hs.2484
GO	cytoplasm [Amigo]  cytoplasm
GO	endoplasmic reticulum [Amigo]  endoplasmic reticulum
GO	microsome [Amigo]  microsome
GO	cell cortex [Amigo]  cell cortex
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	pronucleus [Amigo]  pronucleus
PubGene	TCL1A
TreeFam	TCL1A
CTD	8115 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TCL1A Related clones (RZPD - Berlin)
	PubMed
PubMed	29 Pubmed reference(s) in LocusLink

Bibliography

Chromosome walking on the TCL1 locus involved in T-cell neoplasia.

Virgilio L, Isobe M, Narducci MG, Carotenuto P, Camerini B, Kurosawa N, Abbas-ar-Rushdi, Croce CM, Russo G

Proceedings of the National Academy of Sciences of the United States of America. 1993 ; 90 (20) : 9275-9279.

PMID 8415691

Characterization and localization of the TCL-1 oncogene product.

Fu TB, Virgilio L, Narducci MG, Facchiano A, Russo G, Croce CM

Cancer research. 1994 ; 54 (24) : 6297-6301.

PMID 7987816

Identification of the TCL1 gene involved in T-cell malignancies.

Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G

Proceedings of the National Academy of Sciences of the United States of America. 1994 ; 91 (26) : 12530-12534.

PMID 7809072

TCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia.

Narducci MG, Virgilio L, Isobe M, Stoppacciaro A, Elli R, Fiorilli M, Carbonari M, Antonelli A, Chessa L, Croce CM, Russo G

Blood. 1995 ; 86 (6) : 2358-2364.

PMID 7662982

Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients.

Thick J, Metcalfe JA, Mak YF, Beatty D, Minegishi M, Dyer MJ, Lucas G, Taylor AM

Oncogene. 1996 ; 12 (2) : 379-386.

PMID 8570215

TCL1 is overexpressed in patients affected by adult T-cell leukemias.

Narducci MG, Stoppacciaro A, Imada K, Uchiyama T, Virgilio L, Lazzeri C, Croce CM, Russo G

Cancer research. 1997 ; 57 (24) : 5452-5456.

PMID 9407948

The murine Tcl1 oncogene: embryonic and lymphoid cell expression.

Narducci MG, Virgilio L, Engiles JB, Buchberg AM, Billips L, Facchiano A, Croce CM, Russo G, Rothstein JL

Oncogene. 1997 ; 15 (8) : 919-926.

PMID 9285687

Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology.

Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H

Structure (London, England : 1993). 1998 ; 6 (2) : 147-155.

PMID 9519406

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	03-1998	Marc-Henri Stern

Citation

This paper should be referenced as such :

Stern MH . TCL1A (T-cell leukemia/lymphoma 1A). Atlas Genet Cytogenet Oncol Haematol. March 1998 . URL : http://AtlasGeneticsOncology.org/Genes/TCL1ID66.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Jul 14 17:50:54 2008