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TCL1A (T-cell leukemia/lymphoma 1A)

Written1998-03Marc-Henri Stern
Unité INSERM U462, Centre Hayem, Hopital Saint Louis, 75475 Paris Cedex 10, France

(Note : for Links provided by Atlas : click)


Other namesTCL1 (T Cell Leukemia/Lymphoma 1)
LocusID (NCBI) 8115
Atlas_Id 66
Location 14q32.13  [Link to chromosome band 14q32]
Location_base_pair Starts at 96176304 and ends at 96180533 bp from pter ( according to hg19-Feb_2009)  [Mapping TCL1A.png]
Fusion genes
(updated 2016)
TCL1A (14q32.13) / TCL1A (14q32.13)TCL1A (14q32.13) / TRA ()TCL1A (14q32.13) / VPS8 (3q27.2)
TRA () / TCL1A (14q32.13)TRG () / TCL1A (14q32.13)


Description 4 exons; telomere - exon 1 to 4 - centromere orientation
Transcription 1.3 kb transcripts


Description 114 amino acids; one domain with a b-barrel topology
Expression immature T and B lymphoid cells
Localisation cytoplasm
Function unknown
Homology MTCP1 (38 % identity, similar tridimentional structure)

Implicated in

Entity t(14;14)(q12;q32.1) or inv(14)(q12q32.1) /T-cell malignancies --> TCRA/D - TCL1
Disease mainly T-cell prolymphocytic leukemia (T-PLL); T- cell NHL; T-cell ALL
Cytogenetics associated with i(8q) in T-PLL
Hybrid/Mutated Gene none
Abnormal Protein none
Oncogenesis over expression of TCL1 is considered as critical in the oncogenetic mechanism
Entity t(7;14)(q35;q32.1)/T-cell malignancies --> TCRB - TCL1
Disease mainly T-cell prolymphocytic leukemia
Cytogenetics associated with i(8q)
Hybrid/Mutated Gene none
Abnormal Protein none
Oncogenesis over expression of TCL1


Chromosome walking on the TCL1 locus involved in T-cell neoplasia.
Virgilio L, Isobe M, Narducci MG, Carotenuto P, Camerini B, Kurosawa N, Abbas-ar-Rushdi, Croce CM, Russo G
Proceedings of the National Academy of Sciences of the United States of America. 1993 ; 90 (20) : 9275-9279.
PMID 8415691
Characterization and localization of the TCL-1 oncogene product.
Fu TB, Virgilio L, Narducci MG, Facchiano A, Russo G, Croce CM
Cancer research. 1994 ; 54 (24) : 6297-6301.
PMID 7987816
Identification of the TCL1 gene involved in T-cell malignancies.
Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G
Proceedings of the National Academy of Sciences of the United States of America. 1994 ; 91 (26) : 12530-12534.
PMID 7809072
TCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia.
Narducci MG, Virgilio L, Isobe M, Stoppacciaro A, Elli R, Fiorilli M, Carbonari M, Antonelli A, Chessa L, Croce CM, Russo G
Blood. 1995 ; 86 (6) : 2358-2364.
PMID 7662982
Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients.
Thick J, Metcalfe JA, Mak YF, Beatty D, Minegishi M, Dyer MJ, Lucas G, Taylor AM
Oncogene. 1996 ; 12 (2) : 379-386.
PMID 8570215
TCL1 is overexpressed in patients affected by adult T-cell leukemias.
Narducci MG, Stoppacciaro A, Imada K, Uchiyama T, Virgilio L, Lazzeri C, Croce CM, Russo G
Cancer research. 1997 ; 57 (24) : 5452-5456.
PMID 9407948
The murine Tcl1 oncogene: embryonic and lymphoid cell expression.
Narducci MG, Virgilio L, Engiles JB, Buchberg AM, Billips L, Facchiano A, Croce CM, Russo G, Rothstein JL
Oncogene. 1997 ; 15 (8) : 919-926.
PMID 9285687
Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology.
Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H
Structure (London, England : 1993). 1998 ; 6 (2) : 147-155.
PMID 9519406


This paper should be referenced as such :
Stern, MH
TCL1A (T-cell leukemia/lymphoma 1A)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(2):49-50.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 7 ]
  t(7;14)(q35;q32.1) TRB/TCL1A;inv(14)(q11q32.1) TRA-TRD/TCL1A;t(14;14)(q11;q32.1) TRA-TRD/TCL1A
t(3;7)(q27;q32) MIR29A/BCL6
t(14;14)(q11;q32) CEBPE/IGH;inv(14)(q11q32) CEBPE/IGH
T-lineage acute lymphoblastic leukemia (T-ALL)
Classification of T-Cell disorders
T-cell prolymphocytic leukemia (T-PLL)
t(X;14)(q28;q11.2) TRA-TRD/MTCP1;t(X;7)(q28;q34) TRB/MTCP1

External links

HGNC (Hugo)TCL1A   11648
Entrez_Gene (NCBI)TCL1A  8115  T-cell leukemia/lymphoma 1A
GeneCards (Weizmann)TCL1A
Ensembl hg19 (Hinxton)ENSG00000100721 [Gene_View]  chr14:96176304-96180533 [Contig_View]  TCL1A [Vega]
Ensembl hg38 (Hinxton)ENSG00000100721 [Gene_View]  chr14:96176304-96180533 [Contig_View]  TCL1A [Vega]
ICGC DataPortalENSG00000100721
TCGA cBioPortalTCL1A
Genatlas (Paris)TCL1A
SOURCE (Princeton)TCL1A
Genomic and cartography
GoldenPath hg19 (UCSC)TCL1A  -     chr14:96176304-96180533 -  14q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TCL1A  -     14q32.1   [Description]    (hg38-Dec_2013)
EnsemblTCL1A - 14q32.1 [CytoView hg19]  TCL1A - 14q32.1 [CytoView hg38]
Mapping of homologs : NCBITCL1A [Mapview hg19]  TCL1A [Mapview hg38]
Gene and transcription
Genbank (Entrez)BC003574 BC005831 BC009502 BC009891 BC014024
RefSeq transcript (Entrez)NM_001098725 NM_021966
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)TCL1A
Cluster EST : UnigeneHs.2484 [ NCBI ]
CGAP (NCI)Hs.2484
Alternative Splicing GalleryENSG00000100721
Gene ExpressionTCL1A [ NCBI-GEO ]   TCL1A [ EBI - ARRAY_EXPRESS ]   TCL1A [ SEEK ]   TCL1A [ MEM ]
Gene Expression Viewer (FireBrowse)TCL1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8115
GTEX Portal (Tissue expression)TCL1A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56279 (Uniprot)
NextProtP56279  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56279
Splice isoforms : SwissVarP56279 (Swissvar)
Domains : Interpro (EBI)TCL1_MTCP1   
Domain families : Pfam (Sanger)TCL1_MTCP1 (PF01840)   
Domain families : Pfam (NCBI)pfam01840   
Domain structure : Prodom (Prabi Lyon)TCL1_MTCP1 (PD015575)   
DMDM Disease mutations8115
Blocks (Seattle)TCL1A
Structural Biology KnowledgeBase1JSG   
SCOP (Structural Classification of Proteins)1JSG   
CATH (Classification of proteins structures)1JSG   
Human Protein AtlasENSG00000100721
Peptide AtlasP56279
IPIIPI00178749   IPI01025291   IPI01024968   
Protein Interaction databases
IntAct (EBI)P56279
Ontologies - Pathways
Ontology : AmiGOprotein binding  nucleus  endoplasmic reticulum  multicellular organism development  
Ontology : EGO-EBIprotein binding  nucleus  endoplasmic reticulum  multicellular organism development  
Pathways : KEGGPI3K-Akt signaling pathway   
NDEx Network
Atlas of Cancer Signalling NetworkTCL1A
Wikipedia pathwaysTCL1A
Orthology - Evolution
GeneTree (enSembl)ENSG00000100721
Phylogenetic Trees/Animal Genes : TreeFamTCL1A
Homologs : HomoloGeneTCL1A
Homology/Alignments : Family Browser (UCSC)TCL1A
Gene fusions - Rearrangements
Fusion : MitelmanTRA/TCL1A [-/14q32.13]  [t(14;14)(q11;q32)]  
Fusion : MitelmanTRG/TCL1A [-/14q32.13]  [t(7;14)(p14;q32)]  
Polymorphisms : SNP, variants
NCBI Variation ViewerTCL1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCL1A
Exome Variant ServerTCL1A
ExAC (Exome Aggregation Consortium)TCL1A (select the gene name)
Genetic variants : HAPMAP8115
Genomic Variants (DGV)TCL1A [DGVbeta]
ICGC Data PortalTCL1A 
TCGA Data PortalTCL1A 
Broad Tumor PortalTCL1A
OASIS PortalTCL1A [ Somatic mutations - Copy number]
Cancer Gene: CensusTCL1A 
Somatic Mutations in Cancer : COSMICTCL1A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TCL1A
DgiDB (Drug Gene Interaction Database)TCL1A
DoCM (Curated mutations)TCL1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TCL1A (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
DECIPHER (Syndromes)14:96176304-96180533  ENSG00000100721
CONAN: Copy Number AnalysisTCL1A 
Mutations and Diseases : HGMDTCL1A
Genetic Testing Registry TCL1A
NextProtP56279 [Medical]
Huge Navigator TCL1A [HugePedia]
snp3D : Map Gene to Disease8115
BioCentury BCIQTCL1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8115
Chemical/Pharm GKB GenePA36400
Clinical trialTCL1A
canSAR (ICR)TCL1A (select the gene name)
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jun 11 13:04:22 CEST 2016

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