TCL1A (T-cell leukemia/lymphoma 1A)
1998-03-01 Marc-Henri Stern AffiliationUnité INSERM U462, Centre Hayem, Hopital Saint Louis, 75475 Paris Cedex 10, France
DNA/RNA
Description
4 exons; telomere - exon 1 to 4 - centromere orientation
Transcription
1.3 kb transcripts
Proteins
Description
114 amino acids; one domain with a b-barrel topology
Expression
immature T and B lymphoid cells
Localisation
cytoplasm
Function
unknown
Homology
MTCP1 (38 % identity, similar tridimentional structure)
Implicated in
Entity name
Disease
mainly T-cell prolymphocytic leukemia (T-PLL); T- cell NHL; T-cell ALL
Cytogenetics
associated with i(8q) in T-PLL
Hybrid gene
none
Fusion protein
none
Oncogenesis
over expression of TCL1 is considered as critical in the
oncogenetic mechanism
Entity name
Disease
Cytogenetics
associated with i(8q)
Hybrid gene
none
Fusion protein
none
Oncogenesis
over expression of TCL1
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7987816 | 1994 | Characterization and localization of the TCL-1 oncogene product. | Fu TB et al |
| 9519406 | 1998 | Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. | Hoh F et al |
| 9285687 | 1997 | The murine Tcl1 oncogene: embryonic and lymphoid cell expression. | Narducci MG et al |
| 8570215 | 1996 | Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients. | Thick J et al |
| 7809072 | 1994 | Identification of the TCL1 gene involved in T-cell malignancies. | Virgilio L et al |
Other Information
Locus ID:
NCBI: 8115
MIM: 186960
HGNC: 11648
Ensembl: ENSG00000100721
Variants:
dbSNP: 8115
ClinVar: 8115
TCGA: ENSG00000100721
COSMIC: TCL1A
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| PI3K-Akt signaling pathway | KEGG | hsa04151 |
| PI3K-Akt signaling pathway | KEGG | ko04151 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36317339 | 2023 | TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop. | 3 |
| 37023372 | 2023 | Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia. | 2 |
| 37046083 | 2023 | Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis. | 16 |
| 36317339 | 2023 | TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop. | 3 |
| 37023372 | 2023 | Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia. | 2 |
| 37046083 | 2023 | Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis. | 16 |
| 33760860 | 2021 | Polymorphisms of T- cell leukemia 1A gene loci are not related to the development of adjuvant letrozole-induced adverse events in breast cancer. | 2 |
| 34206047 | 2021 | TCL1A, B Cell Regulation and Tolerance in Renal Transplantation. | 7 |
| 33760860 | 2021 | Polymorphisms of T- cell leukemia 1A gene loci are not related to the development of adjuvant letrozole-induced adverse events in breast cancer. | 2 |
| 34206047 | 2021 | TCL1A, B Cell Regulation and Tolerance in Renal Transplantation. | 7 |
| 33301031 | 2020 | Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling. | 13 |
| 33301031 | 2020 | Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling. | 13 |
| 29048125 | 2018 | TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line. | 4 |
| 29449575 | 2018 | Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL. | 40 |
| 29592948 | 2018 | TCL1A, a Novel Transcription Factor and a Coregulator of Nuclear Factor κB p65: Single Nucleotide Polymorphism and Estrogen Dependence. | 6 |
Citation
Marc-Henri Stern
TCL1A (T-cell leukemia/lymphoma 1A)
Atlas Genet Cytogenet Oncol Haematol. 1998-03-01
Online version: http://atlasgeneticsoncology.org/gene/66/tcl1a
