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TRIM24 24 (tripartite motif-containing 24)

Identity

Other namesTRIM 24 (tripartite motif-containing 24)
PTC6
TF1A
TIF1
RNF82
TIF1A
hTIF1
TIF1ALPHA
HGNC (Hugo) TRIM24
LocusID (NCBI) 8805
Location 7q34
Location_base_pair Starts at 138145079 and ends at 138270332 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Description The TRIM24 gene is organized in 19 exons. There are 2 corresponding transcripts, which give rise to 2 different isoforms (alternative splicing), the first one being shorter.
transcript = 3905 bp; protein = 1016 amino acids; transcript = 4007 bp; protein = 1050 amino acids.

Protein

 
Description TRIM24 encodes a nuclear protein, transcription intermediary factor 1a displaying an RBCC motif (RING finger, B-BOX, and coiled-coil domains, also called tripartite motif, TRIM) in its N-terminus and PHD and bromo domains at the C-terminus. The following is a scheme (not drawn to scale) of the protein and its domains.
Expression ubiquitously and early in development, but also in many adult tissues
Localisation The protein localizes to the nucleus (nuclear bodies).
Function Transcriptional regulator of nuclear receptors, including retinoic acid, thyroid, vitamin D3, and estrogen receptors; participates in multiprotein complexes; interacts with numerous proteins involved in chromatin structure; recruitment of TRIM24 to specific sites in the genome would ensure the localization of initiating RNA polII, and of chromatin remodeling complexes; may function through modulation of chromatin states (regulator of higher order chromatin structures, in order to promote silencing on euchromatic genes); TRIM24 has been demonstrated to possess an intrinsic transcriptional silencing activity which requires histone deacetylation; interacts directly with members of the heterochromatin protein 1 family. May be a key regulator of developmental and physiological processes.
Homology TRIM28/TIF1B, TRIM33/TIF1G, TRIM66/TIF1D

Implicated in

Entity t(7;8)(q34;p11) in leukemia --> TRIM24 - FGFR1
Disease acute myeloid leukemia (AML), 8p11 myeloproliferative syndrome (EMS).
Cytogenetics t(7;8)(q34;p11)
Hybrid/Mutated Gene TRIM24-FGFR1; FGFR1-TRIM24
Abnormal Protein The 2 predicted fusion proteins are organized as follows: TRIM24-FGFR1 contains the RING, BBOX and BBC domains from TRIM24 and the TK domain from FGFR1; FGFR1-TRIM24 contains the signal peptide along with the 3 IG-LIKE and transmembrane domains from FGFR1 and the PHD with the BROMO domains from TRIM24.
  
Entity t(7;10)(q34;q11) in papillary thyroid carcinoma: --> TRIM24- RET
Disease Found in one case of papillary thyroid carcinoma, in a child (a boy aged 4 yrs) exposed to radioactive fallout after the Chernobyl reactor accident (note: children exposed to Chernobyl radioactive fallout frequently developped papillary thyroid carcinoma (PTC), and a very high prevalence of RET rearrangements was found in these childhood PTC, compared to PTC of adults).
Abnormal Protein Fusion of the 5' end of TRIM24 including the RBCC (RING finger, B-BOX, and coiled-coil domains) motif to the 3' end of RET including the tyrosine kinase domain (and loosing the ligand binding and transmembrane domains of RET).
Oncogenesis The fusion protein could form dimers (via the coiled coil domain) and show constitutive tyrosine phosphorylation?
  

Breakpoints

 

External links

Nomenclature
HGNC (Hugo)TRIM24   11812
Entrez_Gene (NCBI)TRIM24  8805  tripartite motif containing 24
Cards
AtlasTRIM24ID504ch7q34
GeneCards (Weizmann)TRIM24
Ensembl (Hinxton)ENSG00000122779 [Gene_View]  chr7:138145079-138270332 [Contig_View]  TRIM24 [Vega]
AceView (NCBI)TRIM24
Genatlas (Paris)TRIM24
euGene (Indiana)8805
SOURCE (Stanford)NM_003852 NM_015905
Genomic and cartography
GoldenPath (UCSC)TRIM24  -  7q34   chr7:138145079-138270332 +  7q32-q34   [Description]    (hg19-Feb_2009)
EnsemblTRIM24 - 7q32-q34 [CytoView]
Mapping of homologs : NCBITRIM24 [Mapview]
OMIM188550   603406   
Gene and transcription
Genbank (Entrez)AA844662 AF009353 AF119042 AK075306 AK127592
RefSeq transcript (SRS)NM_003852 NM_015905
RefSeq transcript (Entrez)NM_003852 NM_015905
RefSeq genomic (SRS)AC_000068 AC_000139 NC_000007 NG_023286 NT_007933 NT_079596 NW_001839072
RefSeq genomic (Entrez)AC_000068 AC_000139 NC_000007 NG_023286 NT_007933 NT_079596 NW_001839072
Consensus coding sequences : CCDS (NCBI)TRIM24
Cluster EST : UnigeneHs.490287 [ SRS ] Hs.490287 [ NCBI ]
Alternative Splicing : Fast-db (Paris)12160
Alternative Splicing GalleryENSG00000122779
Gene ExpressionTRIM24 [ NCBI-GEO ]   TRIM24 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15164 (SRS) O15164 (Uniprot)
With graphics : InterProO15164
Splice isoforms : SwissVarO15164(Swissvar)
Domaine pattern : Prosite (SRS)BROMODOMAIN_1 (PS00633)    BROMODOMAIN_2 (PS50014)    ZF_BBOX (PS50119)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domaine pattern : Prosite (Expaxy)BROMODOMAIN_1 (PS00633)    BROMODOMAIN_2 (PS50014)    ZF_BBOX (PS50119)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (SRS)Bbox_C    Bromodomain    Bromodomain_CS    Zinc_finger_PHD-type_CS    Znf_B-box    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domains : Interpro (EBI)Bbox_C    Bromodomain    Bromodomain_CS    Zinc_finger_PHD-type_CS    Znf_B-box    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Related proteins : CluSTrO15164
Domain families : Pfam (SRS)Bromodomain (PF00439)    PHD (PF00628)    zf-B_box (PF00643)   
Domain families : Pfam (Sanger)Bromodomain (PF00439)    PHD (PF00628)    zf-B_box (PF00643)   
Domain families : Pfam (NCBI)pfam00439    pfam00628    pfam00643   
Domain families : Smart (EMBL)BBC (SM00502)  BBOX (SM00336)  BROMO (SM00297)  PHD (SM00249)  RING (SM00184)  
Blocks (Seattle)O15164
PDB (SRS)2YYN    3O33    3O34    3O35    3O36    3O37   
PDB (PDBSum)2YYN    3O33    3O34    3O35    3O36    3O37   
PDB (IMB)2YYN    3O33    3O34    3O35    3O36    3O37   
PDB (RSDB)2YYN    3O33    3O34    3O35    3O36    3O37   
Human Protein AtlasENSG00000122779
HPRD04556
IPIIPI00005184   IPI00184317   IPI01012915   IPI00444332   IPI00925852   IPI00926068   
Protein Interaction databases
DIP (DOE-UCLA)O15164
IntAct (EBI)O15164
FunCoupENSG00000122779
REACTOMETRIM24
BioGRIDTRIM24
InParanoidO15164
Interologous Interaction database O15164
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TRIM24
SNP (GeneSNP Utah)TRIM24
SNP : HGBaseTRIM24
Genetic variants : HAPMAPTRIM24
Somatic Mutations in Cancer : COSMICTRIM24 
CONAN: Copy Number AnalysisTRIM24 
Translocation Breakpoints in Cancer : TICdbTRIM24 
Mutations and Diseases : HGMDTRIM24
OMIM188550    603406   
GENETests188550    603406   
Disease Genetic AssociationTRIM24
Huge Navigator TRIM24 [HugePedia]  TRIM24 [HugeCancerGEM]
Genomic VariantsTRIM24
snp3D : Map Gene to Disease8805
General knowledge
Homologs : HomoloGeneTRIM24
Homology/Alignments : Family Browser (UCSC)TRIM24
Phylogenetic Trees/Animal Genes : TreeFamTRIM24
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.- [ Enzyme-SRS ]   6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
Chemical/Protein Interactions : CTD8805
Chemical/Pharm GKB GenePA36519
Clinical trialTRIM24
Cancer Resource (Charite)ENSG00000122779
Ontology : AmiGOp53 binding  chromatin binding  transcription coactivator activity  protein kinase activity  ubiquitin-protein ligase activity  receptor binding  protein binding  intracellular  nucleus  nuclear euchromatin  perichromatin fibrils  cytoplasm  transcription from RNA polymerase II promoter  zinc ion binding  negative regulation of cell proliferation  protein ubiquitination  ligase activity  ligand-dependent nuclear receptor binding  protein catabolic process  regulation of protein stability  estrogen response element binding  methylated histone residue binding  regulation of apoptotic process  sequence-specific DNA binding  negative regulation of transcription, DNA-dependent  positive regulation of transcription, DNA-dependent  protein autophosphorylation  metal ion binding  calcium ion homeostasis  regulation of vitamin D receptor signaling pathway  histone acetyl-lysine binding  cellular response to estrogen stimulus  
Ontology : EGO-EBIp53 binding  chromatin binding  transcription coactivator activity  protein kinase activity  ubiquitin-protein ligase activity  receptor binding  protein binding  intracellular  nucleus  nuclear euchromatin  perichromatin fibrils  cytoplasm  transcription from RNA polymerase II promoter  zinc ion binding  negative regulation of cell proliferation  protein ubiquitination  ligase activity  ligand-dependent nuclear receptor binding  protein catabolic process  regulation of protein stability  estrogen response element binding  methylated histone residue binding  regulation of apoptotic process  sequence-specific DNA binding  negative regulation of transcription, DNA-dependent  positive regulation of transcription, DNA-dependent  protein autophosphorylation  metal ion binding  calcium ion homeostasis  regulation of vitamin D receptor signaling pathway  histone acetyl-lysine binding  cellular response to estrogen stimulus  
Other databases
Probes
Probes : ImagenesTRIM24 Related clones (RZPD - Berlin)
Litterature
PubMed43 Pubmed reference(s) in Entrez
PubGeneTRIM24
iHOPTRIM24

Bibliography

A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.
Le Douarin B, Nielsen AL, Garnier JM, Ichinose H, Jeanmougin F, Losson R, Chambon P
The EMBO journal. 1996 ; 15 (23) : 6701-6715.
PMID 8978696
 
Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.
Thˆ©not S, Henriquet C, Rochefort H, Cavaillˆ®s V
The Journal of biological chemistry. 1997 ; 272 (18) : 12062-12068.
PMID 9115274
 
The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas.
Klugbauer S, Rabes HM
Oncogene. 1999 ; 18 (30) : 4388-4393.
PMID 10439047
 
TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids.
Khetchoumian K, Teletin M, Mark M, Lerouge T, Cerviˆ±o M, Oulad-Abdelghani M, Chambon P, Losson R
The Journal of biological chemistry. 2004 ; 279 (46) : 48329-48341.
PMID 15322135
 
8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes.
Belloni E, Trubia M, Gasparini P, Micucci C, Tapinassi C, Confalonieri S, Nuciforo P, Martino B, Lo-Coco F, Pelicci PG, Di Fiore PP
Genes, chromosomes & cancer. 2005 ; 42 (3) : 320-325.
PMID 15609342
 
Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote.
Torres-Padilla ME, Zernicka-Goetz M
The Journal of cell biology. 2006 ; 174 (3) : 329-338.
PMID 16880268
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written02-2006Elena Belloni, Pier Giuseppe Pelicci, Pier Paolo Di Fiore
Updated12-2006Jean Loup Huret

Citation

This paper should be referenced as such :
Belloni E, Pelicci PG, Di Fiore PP . TRIM24 24 (tripartite motif-containing 24). Atlas Genet Cytogenet Oncol Haematol. February 2006 .
URL : http://AtlasGeneticsOncology.org/Genes/TRIM24ID504ch7q34.html
Huret JL . TRIM24 24 (tripartite motif-containing 24). Atlas Genet Cytogenet Oncol Haematol. December 2006 .
URL : http://AtlasGeneticsOncology.org/Genes/TRIM24ID504ch7q34.html

This paper is referenced by INIST as such :
   [ Bibliographic record ]
http://documents.irevues.inist.fr/bitstream/2042/38410/1/12-2006-TRIM24ID504ch7q34.pdf   [ Bibliographic record ]

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indexed on : Sat Apr 28 15:07:28 CEST 2012

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