The TRIM24 gene is organized in 19 exons. There are 2 corresponding transcripts, which give rise to 2 different isoforms (alternative splicing), the first one being shorter.
transcript = 3905 bp; protein = 1016 amino acids; transcript = 4007 bp; protein = 1050 amino acids.

TRIM24 encodes a nuclear protein, transcription intermediary factor 1a displaying an RBCC motif (RING finger, B-BOX, and coiled-coil domains, also called tripartite motif, TRIM) in its N-terminus and PHD and bromo domains at the C-terminus. The following is a scheme (not drawn to scale) of the protein and its domains.

ubiquitously and early in development, but also in many adult tissues

The protein localizes to the nucleus (nuclear bodies).

Transcriptional regulator of nuclear receptors, including retinoic acid, thyroid, vitamin D3, and estrogen receptors; participates in multiprotein complexes; interacts with numerous proteins involved in chromatin structure; recruitment of TRIM24 to specific sites in the genome would ensure the localization of initiating RNA polII, and of chromatin remodeling complexes; may function through modulation of chromatin states (regulator of higher order chromatin structures, in order to promote silencing on euchromatic genes); TRIM24 has been demonstrated to possess an intrinsic transcriptional silencing activity which requires histone deacetylation; interacts directly with members of the heterochromatin protein 1 family. May be a key regulator of developmental and physiological processes.

TRIM28/TIF1B, TRIM33/TIF1G, TRIM66/TIF1D