DAXX (death-associated protein 6)

2009-01-01 Eunhee Kim Affiliation

School of Bioscience & Biotechnology, Chungnam National University, 220 Goong-dong, Yusung-gu, Daejeon, 305-764, Korea (South)

Identity

HGNC

DAXX

LOCATION

6p21.32

IMAGE

LOCUSID

1616

ALIAS

BING2,DAP6,EAP1,SMIM40

FUSION GENES

Show Gene Fusions

DNA/RNA

Description

Daxx gene has 8 exons on chromosome 6. The sizes of the exons are 66, 256, 832, 212, 214, 475, 223 and 191 bps.

Transcription

2,477 bp mRNA.
Two alternative transcripts:
1. Isoform 1 has been chosen as the canonical sequence
2. Isoform 2 differs from the canonical sequence as follows:
696-740: SSLCIPSPARLSQTPHSQPPRPGTCKTSVATQCDPEEIIVLSDSDPAKNLGRRRSKQDQG

Proteins

Description

740 amino acids, 82.2 kDa; contains in 3 coiled coils (residues 180-217, 358-399 and 430-489), and 2 nuclear localisation signals (residues 391-395 and 628-634).

Expression

Ubiquitous.

Localisation

Nucleus and cytoplasm.
Note: Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli.
Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres.
Detected in the cytoplasmic punctate structures.
Translocated from the nucleus to the cytoplasm upon glucose deprivation or ischemic stress.

Function

Interaction with Fas death domain and induces Fas-mediated cell death.

Establishes Fas-Daxx-ASK1-JNK axis.

Implicated in ischemic cell death. Daxx translocates from the nucleus to the cytoplasm upon ischemic stress. Cytoplasmic Daxx interacts with NHE1 and stimulates the NHE1 transporter activity and suppresses the NHE1-ezrin-AKT1 pathway.

Associated with the PML body in the nucleus.

Interacts with SUMO1 and UBC9 and is sumorylated at K630 and 631. However, the sumoylation status does not determine its localization onto the PML body.

Mediates SUMO-dependent transcriptional control and subnuclear compartmentalization.

Suppresses cell death in the early embryo.

Daxx silencing sensitizes cells to Fas- and stress-induced cell death through caspase activation, cytochrome C release and JNK activation.

Homology

Holomogy with Pan troglodytes (99%); Canis lupus familiaris (89%); Bos taurus (83%); Mus musculus (70%), Rattus norvegicus (73%).

Mutations

Note

Substitutions (see the external links).

Implicated in

Entity name

Promyelocytic leukemia

Disease

Daxx is a component of the promyelocytic leukemia protein (PML) nuclear bodies (NBs).

Entity name

Alpha-thalassemia

Disease

Daxx complex is a novel ATP-dependent chromatin-remodeling complex, with alpha-thalassaemia syndrome protein (ATRX) being the core ATPase subunit and Daxx being the targeting subunit.

Entity name

Leukemia

Disease

Daxx protein was expressed in 38.0% of 50 children with acute leukemia, which was significantly higher than that of the control group (5.0%) (P < 0.05). Daxx expression is abnormal in children with acute leukemia and associated with some clinical features of acute leukemia, suggesting that it may play an important role in the genesis and development of acute leukemia.

Article Bibliography

Pubmed ID	Last Year	Title	Authors
15929099	2005	Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition.	Alkan S et al
11703323	2001	Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of daxx in acute promyelocytic leukaemia with t(15;17).	Amin HM et al
18456001	2008	Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death.	Awasthi YC et al
15302935	2004	Large-scale characterization of HeLa cell nuclear phosphoproteins.	Beausoleil SA et al
14722267	2004	Nuclear localization but not PML protein is required for incorporation of the papillomavirus minor capsid protein L2 into virus-like particles.	Becker KA et al
15359646	2004	In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis.	Boehrer S et al
15683751	2005	Expression of Daxx sensitizes Jurkat T-cells to the apoptosis-inducing effect of chemotherapeutic agents.	Boehrer S et al
15183120	2004	In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors.	Brieger A et al
16731959	2006	Human cytomegalovirus (HCMV) UL82 gene product (pp71) relieves hDaxx-mediated repression of HCMV replication.	Cantrell SR et al
11773067	2002	Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules.	Cermák L et al
15637079	2005	Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4.	Chang CC et al
9743501	1998	Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.	Chang HY et al
9990010	1999	Dissecting Fas signaling with an altered-specificity death-domain mutant: requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation.	Chang HY et al
11493600	2001	A kinase-independent function of Ask1 in caspase-independent cell death.	Charette SJ et al
16475184	2006	SUMO regulates the cytoplasmonuclear transport of its target protein Daxx.	Chen A et al
17098929	2006	DAXX interacts with phage PhiC31 integrase and inhibits recombination.	Chen JZ et al
14517282	2003	Daxx silencing sensitizes cells to multiple apoptotic pathways.	Chen LY et al
16638211	2006	[Expression of apoptosis-related proteins in the human bone marrow hematopoietic cells treated by Panax Notoginosides].	Chen XH et al
18480407	2008	Live cell dynamics of promyelocytic leukemia nuclear bodies upon entry into and exit from mitosis.	Chen YC et al
14761963	2004	Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1.	Cho S et al
12948851	2003	Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation.	Chow KU et al
16982744	2006	Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB.	Croxton R et al
12529400	2003	Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.	Ecsedy JA et al
11799127	2002	The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells.	Emelyanov AV et al
11716541	2001	Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies.	Engelhardt OG et al
17670833	2007	Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts.	Everett RD et al
12033769	2002	Reorganization of nuclear domain 10 induced by papillomavirus capsid protein l2.	Florin L et al
11099484	2001	HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism.	Genini D et al
15489334	2004	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).	Gerhard DS et al
11420043	2001	An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons.	Gongora R et al
15339933	2004	The transcriptional repressor hDaxx potentiates p53-dependent apoptosis.	Gostissa M et al
15795247	2005	The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription.	Greger JG et al
17947514	2007	Knockdown of hDaxx in normally non-permissive undifferentiated cells does not permit human cytomegalovirus immediate-early gene expression.	Groves IJ et al
16955392	2006	Gene expression profiling of human synovial sarcoma cell line (Hs701.T) in response to IL-1beta stimulation.	Ha WY et al
9521053	1998	Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC.	Herberg JA et al
11992005	2002	Functional interaction between the pp71 protein of human cytomegalovirus and the PML-interacting protein human Daxx.	Hofmann H et al
14678985	2003	HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells.	Hofmann TG et al
12140263	2002	Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.	Hollenbach AD et al
17590404	2007	Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells.	Hwang J et al
16038411	2005	C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis.	Hwang JR et al
15781341	2005	Differential effects of a novel IFN-zeta/limitin and IFN-alpha on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes.	Ishida N et al
10525530	1999	PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1.	Ishov AM et al
15252119	2004	Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX.	Ishov AM et al
12150977	2002	Modification of Daxx by small ubiquitin-related modifier-1.	Jang MS et al
18196534	2008	Critical roles for JNK, c-Jun, and Fas/FasL-Signaling in vitamin E analog-induced apoptosis in human prostate cancer cells.	Jia L et al
18003619	2008	Physical interactions and functional coupling between Daxx and sodium hydrogen exchanger 1 in ischemic cell death.	Jung YS et al
15983381	2005	Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.	Junn E et al
9740801	1998	Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade.	Juo P et al
18242185	2008	Proteasome inhibitor MG132 blocks viral DNA replication and assembly of human cytomegalovirus.	Kaspari M et al
12917339	2003	ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.	Kawai T et al
15861194	2005	Daxx is required for stress-induced cell death and JNK activation.	Khelifi AF et al
12954772	2003	Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML.	Kim EJ et al
16088932	2005	Upregulation of Daxx mediates apoptosis in response to oxidative stress.	Kim KS et al
14637155	2003	Long form of cellular FLICE-inhibitory protein interacts with Daxx and prevents Fas-induced JNK activation.	Kim YY et al
9407001	1997	Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region.	Kiriakidou M et al
16810318	2006	Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.	Kitagawa D et al
11495919	2001	Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm.	Ko YG et al
16287980	2005	SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx.	Kuo HY et al
16524876	2006	BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.	Kwon JE et al
15240113	2004	Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP.	La M et al
11842083	2002	The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1.	Lalioti VS et al
11244500	2001	Regulation of Pax3 transcriptional activity by SUMO-1-modified PML.	Lehembre F et al
16679534	2006	CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus.	Lemos TA et al
17384262	2006	HGF/SF regulates expression of apoptotic genes in MCF-10A human mammary epithelial cells.	Leroy C et al
10669754	2000	Sequestration and inhibition of Daxx-mediated transcriptional repression by PML.	Li H et al
10698492	2000	EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.	Li R et al
11907324	2002	Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx.	Li XD et al
16566946	2006	Effect of sinomenine on gene expression of the IL-1 beta-activated human synovial sarcoma.	Li XJ et al
17707345	2007	Sensitization to Fas-mediated apoptosis by dengue virus capsid protein.	Limjindaporn T et al
15572661	2004	Negative modulation of androgen receptor transcriptional activity by Daxx.	Lin DY et al
17081986	2006	Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors.	Lin DY et al
12595526	2003	Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential.	Lin DY et al
11948183	2002	Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration.	Lin DY et al
17404597	2007	Axin bridges Daxx to p53.	Lin SC et al
17471023	2007	Daxx shortens mitotic arrest caused by paclitaxel.	Lindsay CR et al
17306074	2007	[Expression of Daxx in children with acute leukemia].	Liu J et al
12186918	2002	Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins.	Lopez P et al
11971979	2002	Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell.	Lopez P et al
8125298	1994	Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.	Maruyama K et al
18264718	2008	Differences between mouse and human cytomegalovirus interactions with their respective hosts at immediate early times of the replication cycle.	Maul GG et al
17360386	2007	Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts.	Meinecke I et al
12482920	2003	RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX.	Michaelson JS et al
15087395	2004	Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs.	Mo YY et al
14574404	2003	The DNA sequence and analysis of human chromosome 6.	Mungall AJ et al
16861237	2006	Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx.	Murakami Y et al
16331268	2006	Physical and functional interactions between Daxx and STAT3.	Muromoto R et al
16455055	2006	Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins.	Nery FC et al
17891170	2008	Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy.	Nieto-Miguel T et al
12482984	2003	Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53.	Ohiro Y et al
17081983	2006	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.	Olsen JV et al
17362989	2007	Inhibition of NF-kappaB acetylation and its transcriptional activity by Daxx.	Park J et al
11483955	2001	TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.	Perlman R et al
9645950	1998	Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death.	Pluta AF et al
18094192	2008	Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response.	Poleshko A et al
16603511	2006	Role of the cellular protein hDaxx in human cytomegalovirus immediate-early gene expression.	Preston CM et al
18413714	2008	Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation.	Puto LA et al
14499622	2003	Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.	Reuter TY et al
11034606	2000	FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.	Rochat-Steiner V et al
17938171	2007	A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx.	Ryo A et al
11112409	2000	Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9.	Ryu SW et al
17596307	2007	Human cytomegalovirus gene expression is silenced by Daxx-mediated intrinsic immune defense in model latent infections established in vitro.	Saffert RT et al
16406523	2006	Daxx: death or survival protein?	Salomoni P et al
18069800	2008	4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas.	Sharma R et al
18031230	2007	Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization.	Shih HM et al
15998799	2005	Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop.	Song JJ et al
11881150	2001	[Monoclonal antibodies against protein Daxx and its localization in nuclear domains 10].	Sotnikov AG et al
12477932	2002	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL et al
17370120	2007	Anti-apoptotic effects of probucol are associated with downregulation of Daxx expression in THP-1 macrophage.	Su B et al
9373149	1997	Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.	Suzuki Y et al
15077145	2004	PML nuclear bodies and apoptosis.	Takahashi Y et al
15878163	2005	The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62.	Tang J et al
14990586	2004	A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein.	Tang J et al
17942542	2008	Nuclear domain 10 components promyelocytic leukemia protein and hDaxx independently contribute to an intrinsic antiviral defense against human cytomegalovirus infection.	Tavalai N et al
10545115	1999	Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs).	Torii S et al
18200667	2008	Effect of Daxx on cholesterol accumulation in hepatic cells.	Tuo QH et al
16569639	2006	Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells.	Tzeng SL et al
10903735	2000	Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD.	Villunger A et al
17035242	2006	Human Daxx-mediated repression of human cytomegalovirus gene expression correlates with a repressive chromatin structure around the major immediate early promoter.	Woodhall DL et al
12407442	2002	Ultraviolet radiation-induced apoptosis is mediated by Daxx.	Wu S et al
12953102	2003	The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies.	Xue Y et al
9215629	1997	Daxx, a novel Fas-binding protein that activates JNK and apoptosis.	Yang X et al
12086872	2002	Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.	Yeoh EJ et al
17661348	2008	Daxx contains two nuclear localization signals and interacts with importin alpha3.	Yeung PL et al
14557665	2003	Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx.	Zhao LY et al
10684855	2000	Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis.	Zhong S et al
17389020	2007	Sequence variation within the major histocompatibility complex subregion centromeric of HLA class II in type 1 diabetes.	van der Slik AR et al

Other Information

Locus ID:

NCBI: 1616
MIM: 603186
HGNC: 2681
Ensembl: ENSG00000204209

Variants:

dbSNP: 1616
ClinVar: 1616
TCGA: ENSG00000204209
COSMIC: DAXX

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204209	ENST00000266000	Q9UER7
ENSG00000204209	ENST00000266000	A0A024RCS3
ENSG00000204209	ENST00000374542	Q9UER7
ENSG00000204209	ENST00000374542	A0A024RCS3
ENSG00000204209	ENST00000414083	Q9UER7
ENSG00000204209	ENST00000446403	Q4VX54
ENSG00000204209	ENST00000446511	A2AB94
ENSG00000204209	ENST00000620164	Q9UER7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Apoptosis	KEGG	ko04210
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
MAPK signaling pathway	KEGG	hsa04010
Apoptosis	KEGG	hsa04210
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Expression and Degradation	REACTOME	R-HSA-6806003
Regulation of TP53 Degradation	REACTOME	R-HSA-6804757

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38038252	2024	DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks.	0
38038252	2024	DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks.	0
35691289	2023	DAXX, ATRX, and MSI in PanNET and Their Metastases: Correlation with Histopathological Data and Prognosis.	0
36868228	2023	DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network.	18
37396746	2023	The Impact of Human Mammary Tumor Virus (HMTV) on the Expression of Epidermal Growth Factor Receptor (EGFR) and Death-Domain Associated Protein (DAXX) in Breast Carcinoma Tissues.	0
37871853	2023	HPV16 E7 protein antagonizes TNF-α-induced apoptosis of cervical cancer cells via Daxx/JNK pathway.	1
35691289	2023	DAXX, ATRX, and MSI in PanNET and Their Metastases: Correlation with Histopathological Data and Prognosis.	0
36868228	2023	DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network.	18
37396746	2023	The Impact of Human Mammary Tumor Virus (HMTV) on the Expression of Epidermal Growth Factor Receptor (EGFR) and Death-Domain Associated Protein (DAXX) in Breast Carcinoma Tissues.	0
37871853	2023	HPV16 E7 protein antagonizes TNF-α-induced apoptosis of cervical cancer cells via Daxx/JNK pathway.	1
35718818	2022	Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth.	5
36162510	2022	Death domain-associated protein DAXX regulates noncoding RNA transcription at the centromere through the transcription regulator ZFAT.	1
35718818	2022	Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth.	5
36162510	2022	Death domain-associated protein DAXX regulates noncoding RNA transcription at the centromere through the transcription regulator ZFAT.	1
32694250	2021	Direct Interaction of Daxx and Androgen Receptor Is Required for Their Regulatory Activity in Cholesterol Biosynthesis.	3

Citation

Eunhee Kim

DAXX (death-associated protein 6)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/40265/meetings/css/lib/gene-fusions/?id=40265