SARNP (cytokine induced protein 29 kDa)

2005-08-01   Jean-Loup Huret  , Sylvie Senon  

Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
12q13.2
LOCUSID
ALIAS
CIP29,HCC1,HSPC316,THO1
FUSION GENES

Proteins

Description

210 amino acids, 29 kDa;contains from N term to C term a SAP domain and 2 nuclear localization domains, and also 3 possible N-glycosylation sites and 9 potential phosphorylation sites. A SAP domain is a putative DNA binding motif involved in chromosomal organization and may regulate transcription, DNA repair, RNA processing.

Expression

Widely expressed in fetal and adult tissues, as well as cancer cell lines; upregulated by EPO (erythropoietin), TPO (thrombopoietin), FL (FLT3 Ligand), and SCF (stem cell factor). Associated with cell cycle progression

Localisation

Nucleus but some staining was also found in the cytoplasm.

Implicated in

Entity name
M4 acute myeloid leukemia (AML) with t(11;12)(q23;q13) --> KMT2A/SARNP
Note
only one case to date
Prognosis
unknown
Hybrid gene
5 MLL - 3 CIP29 including the 9 first exons of MLL, and nearly the entire CIP29
Fusion protein
The fusion protein includes from N term to C term the AT hooks and the methyltransferase domain of MLL and the SAP domain and the C term nuclear localization domains of CIP29.

Article Bibliography

Pubmed IDLast YearTitleAuthors
159242602005Growth inhibitory effect of Hcc-1/CIP29 is associated with induction of apoptosis, not just with G2/M arrest.Fukuda S et al
119226082002Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29.Fukuda S et al
152848552004A novel partner gene CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic leukemia.Hashii Y et al

Other Information

Locus ID:

NCBI: 84324
MIM: 610049
HGNC: 24432
Ensembl: ENSG00000205323

Variants:

dbSNP: 84324
ClinVar: 84324
TCGA: ENSG00000205323
COSMIC: SARNP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205323ENST00000336133P82979
ENSG00000205323ENST00000546604P82979
ENSG00000205323ENST00000552080F8VZQ9
ENSG00000205323ENST00000552884F8VS12

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375788632023Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly.3
375788632023Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly.3
313138372020SARNP, a participant in mRNA splicing and export, negatively regulates E-cadherin expression via interaction with pinin.11
313138372020SARNP, a participant in mRNA splicing and export, negatively regulates E-cadherin expression via interaction with pinin.11
271897102016Interactions between KSHV ORF57 and the novel human TREX proteins, CHTOP and CIP29.4
271897102016Interactions between KSHV ORF57 and the novel human TREX proteins, CHTOP and CIP29.4
171969632007Intracellular characterization of DDX39, a novel growth-associated RNA helicase.33
171969632007Intracellular characterization of DDX39, a novel growth-associated RNA helicase.33
153380562004Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function.14
153380562004Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function.14
119226082002Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29.15
119226082002Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29.15

Citation

Jean-Loup Huret ; Sylvie Senon

SARNP (cytokine induced protein 29 kDa)

Atlas Genet Cytogenet Oncol Haematol. 2005-08-01

Online version: http://atlasgeneticsoncology.org/gene/42967/haematological-explorer/haematological-explorer/