TCL1A (T-cell leukemia/lymphoma 1A)

1998-03-01 Marc-Henri Stern Affiliation

Unité INSERM U462, Centre Hayem, Hopital Saint Louis, 75475 Paris Cedex 10, France

Identity

HGNC

TCL1A

LOCATION

14q32.13

LOCUSID

8115

ALIAS

TCL1

FUSION GENES

Show Gene Fusions

DNA/RNA

Description

4 exons; telomere - exon 1 to 4 - centromere orientation

Transcription

1.3 kb transcripts

Proteins

Description

114 amino acids; one domain with a b-barrel topology

Expression

immature T and B lymphoid cells

Localisation

cytoplasm

Function

unknown

Homology

MTCP1 (38 % identity, similar tridimentional structure)

Implicated in

Entity name

t(14;14)(q12;q32.1) or inv(14)(q12q32.1) /T-cell malignancies --> TCRA/D - TCL1A

Disease

mainly T-cell prolymphocytic leukemia (T-PLL); T- cell NHL; T-cell ALL

Cytogenetics

associated with i(8q) in T-PLL

Hybrid gene

none

Fusion protein

none

Oncogenesis

over expression of TCL1 is considered as critical in the oncogenetic mechanism

Entity name

t(7;14)(q35;q32.1)/T-cell malignancies --> TCRB - TCL1A

Disease

mainly T-cell prolymphocytic leukemia

Cytogenetics

associated with i(8q)

Hybrid gene

none

Fusion protein

none

Oncogenesis

over expression of TCL1

Bibliography

Pubmed ID	Last Year	Title	Authors
7987816	1994	Characterization and localization of the TCL-1 oncogene product.	Fu TB et al
9519406	1998	Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology.	Hoh F et al
9285687	1997	The murine Tcl1 oncogene: embryonic and lymphoid cell expression.	Narducci MG et al
8570215	1996	Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients.	Thick J et al
7809072	1994	Identification of the TCL1 gene involved in T-cell malignancies.	Virgilio L et al

Other Information

Locus ID:

NCBI: 8115
MIM: 186960
HGNC: 11648
Ensembl: ENSG00000100721

Variants:

dbSNP: 8115
ClinVar: 8115
TCGA: ENSG00000100721
COSMIC: TCL1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100721	ENST00000402399	P56279
ENSG00000100721	ENST00000402399	A0A024R6G5
ENSG00000100721	ENST00000554012	P56279
ENSG00000100721	ENST00000554012	A0A024R6G5
ENSG00000100721	ENST00000554119	G3V4T4
ENSG00000100721	ENST00000555202	P56279
ENSG00000100721	ENST00000555202	A0A024R6G5
ENSG00000100721	ENST00000555886	G3V4T4
ENSG00000100721	ENST00000556156	G3V4T4
ENSG00000100721	ENST00000556450	P56279
ENSG00000100721	ENST00000556450	A0A024R6G5
ENSG00000100721	ENST00000557043	H0YJR9

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36317339	2023	TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop.	3
37023372	2023	Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.	2
37046083	2023	Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.	16
36317339	2023	TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop.	3
37023372	2023	Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.	2
37046083	2023	Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.	16
33760860	2021	Polymorphisms of T- cell leukemia 1A gene loci are not related to the development of adjuvant letrozole-induced adverse events in breast cancer.	2
34206047	2021	TCL1A, B Cell Regulation and Tolerance in Renal Transplantation.	7
33760860	2021	Polymorphisms of T- cell leukemia 1A gene loci are not related to the development of adjuvant letrozole-induced adverse events in breast cancer.	2
34206047	2021	TCL1A, B Cell Regulation and Tolerance in Renal Transplantation.	7
33301031	2020	Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.	13
33301031	2020	Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.	13
29048125	2018	TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line.	4
29449575	2018	Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.	40
29592948	2018	TCL1A, a Novel Transcription Factor and a Coregulator of Nuclear Factor κB p65: Single Nucleotide Polymorphism and Estrogen Dependence.	6

Citation

Marc-Henri Stern

TCL1A (T-cell leukemia/lymphoma 1A)

Atlas Genet Cytogenet Oncol Haematol. 1998-03-01

Online version: http://atlasgeneticsoncology.org/gene/66/img/teaching-explorer/deep-insight-explorer/