LCP1 (lymphocyte cytosolic protein1)

1998-03-01   Sylvie Galiègue-Zouitina 

U.124 INSERM, I.R.C.L., Place de Verdun, 59045 LILLE Cedex, France

Identity

HGNC
LCP1
LOCATION
13q14.13
LOCUSID
3936
ALIAS
CP64,HEL-S-37,L-PLASTIN,LC64P,LPL,PLS2
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

spans on a 90 kb genomic fragment; 16 exons, large first intron (20kb)

Transcription

3.7 kb mRNA; coding sequence from exon 2 to exon 16: 3500 bp

Proteins

Description

570 amino acids

Expression

restricted to the hematopoietic cells (leukocytes); expression induced in all tumor cells of all tissues

Localisation

membrane

Homology

belongs to an actin-binding protein family (T-Plastin, Fimbrin, I-Plastin)

Implicated in

Entity name
t(3;13)(q27;q14)/ NHL --> LCP1 - BCL6
Disease
non Hodgkin follicular as well as Burkitt lymphomas
Cytogenetics
t(3;13) is observed as a secondary anomaly
Hybrid gene
both 5 L-Plastin- 3 BCL6 and 5 BCL6 - 3 L-Plastin, leading to two fusion transcripts
Fusion protein
no fusion protein, but promoter exchange between both partner genes

Bibliography

Pubmed IDLast YearTitleAuthors

Other Information

Locus ID:

NCBI: 3936
MIM: 153430
HGNC: 6528
Ensembl: ENSG00000136167

Variants:

dbSNP: 3936
ClinVar: 3936
TCGA: ENSG00000136167
COSMIC: LCP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136167ENST00000323076P13796
ENSG00000136167ENST00000323076A0A024RDT4
ENSG00000136167ENST00000398576P13796
ENSG00000136167ENST00000398576A0A024RDT4
ENSG00000136167ENST00000416500Q5TBN3
ENSG00000136167ENST00000442275Q5TBN5

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
129636942003Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D.53
166360792006Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells.44
162870742006The leukocyte protein L-plastin induces proliferation, invasion and loss of E-cadherin expression in colon cancer cells.31
206838992010Sustained LFA-1 cluster formation in the immune synapse requires the combined activities of L-plastin and calmodulin.31
172944032007Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25.30
225818622012L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes.30
232130742013Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.25
172903932007Phosphorylation of ectopically expressed L-plastin enhances invasiveness of human melanoma cells.21
201691552010Quantitative kinetic study of the actin-bundling protein L-plastin and of its impact on actin turn-over.17
215253902011Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin.17

Citation

Sylvie Galiègue-Zouitina

LCP1 (lymphocyte cytosolic protein1)

Atlas Genet Cytogenet Oncol Haematol. 1998-03-01

Online version: http://atlasgeneticsoncology.org/gene/95/cancer-prone-explorer/favicon/js/lib/popper.js