LCP1 (lymphocyte cytosolic protein1)

1998-03-01   Sylvie Galiègue-Zouitina 

U.124 INSERM, I.R.C.L., Place de Verdun, 59045 LILLE Cedex, France

Identity

HGNC
LOCATION
13q14.13
LOCUSID
ALIAS
CP64,HEL-S-37,L-PLASTIN,LC64P,LPL,PLS2
FUSION GENES

DNA/RNA

Description

spans on a 90 kb genomic fragment; 16 exons, large first intron (20kb)

Transcription

3.7 kb mRNA; coding sequence from exon 2 to exon 16: 3500 bp

Proteins

Description

570 amino acids

Expression

restricted to the hematopoietic cells (leukocytes); expression induced in all tumor cells of all tissues

Localisation

membrane

Homology

belongs to an actin-binding protein family (T-Plastin, Fimbrin, I-Plastin)

Implicated in

Entity name
Disease
non Hodgkin follicular as well as Burkitt lymphomas
Cytogenetics
t(3;13) is observed as a secondary anomaly
Hybrid gene
both 5 L-Plastin- 3 BCL6 and 5 BCL6 - 3 L-Plastin, leading to two fusion transcripts
Fusion protein
no fusion protein, but promoter exchange between both partner genes

Bibliography

Pubmed IDLast YearTitleAuthors

Other Information

Locus ID:

NCBI: 3936
MIM: 153430
HGNC: 6528
Ensembl: ENSG00000136167

Variants:

dbSNP: 3936
ClinVar: 3936
TCGA: ENSG00000136167
COSMIC: LCP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136167ENST00000323076P13796
ENSG00000136167ENST00000323076A0A024RDT4
ENSG00000136167ENST00000398576P13796
ENSG00000136167ENST00000398576A0A024RDT4
ENSG00000136167ENST00000416500Q5TBN3
ENSG00000136167ENST00000442275Q5TBN5

Expression (GTEx)

0
500
1000
1500

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129636942003Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D.53
166360792006Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells.44
162870742006The leukocyte protein L-plastin induces proliferation, invasion and loss of E-cadherin expression in colon cancer cells.31
206838992010Sustained LFA-1 cluster formation in the immune synapse requires the combined activities of L-plastin and calmodulin.31
172944032007Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25.30
225818622012L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes.30
232130742013Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.25
172903932007Phosphorylation of ectopically expressed L-plastin enhances invasiveness of human melanoma cells.21
201691552010Quantitative kinetic study of the actin-bundling protein L-plastin and of its impact on actin turn-over.17
215253902011Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin.17

Citation

Sylvie Galiègue-Zouitina

LCP1 (lymphocyte cytosolic protein1)

Atlas Genet Cytogenet Oncol Haematol. 1998-03-01

Online version: http://atlasgeneticsoncology.org/gene/95/lcp1-(lymphocyte-cytosolic-protein1)