PAX5 (paired box gene 5)

9p13.2

Lineage-specific transcription factor; recognizes the concensus recognition sequence GNCCANTGAAGCGTGAC, where N is any nucleotide. Involved in B-cell differentiation. Entry of common lymphoid progenitors into the B cell lineage depends on E2A, EBF1, and PAX5; activates B-cell specific genes and repress genes involved in other lineage commitments. Activates the surface cell receptor CD19 and repress FLT3. Pax5 physically interacts with the RAG1/RAG2 complex, and removes the inhibitory signal of the lysine-9-methylated histone H3, and induces V-to-DJ rearrangements. Genes repressed by PAX5 expression in early B cells are restored in their function in mature B cells and plasma cells, and PAX5 repressed (Fuxa et al., 2004; Johnson et al., 2004; Zhang et al., 2006; Cobaleda et al., 2007).

SLCO1B3 (solute carrier organic anion transporter family member 1B3)

12p12.2

Multi-pass membrane protein. Organic anion transporting polypeptide. Mediates the transport for various molecules such as bile acids, steroids, thyroid hormones, and exogenous drugs. Normally expressed in the basolateral membrane of hepatocytes around the central vein (Hagenbuch and Meier, 2003; Briz et al., 2006).