MLLT11 (ALL1 fused gene from chromosome 1q)
1998-04-01 Olivier Bernard AffiliationUnite Inserm U434, CNRS, Institut de Genetique Moleculaire, Paris, France
Identity
HGNC
LOCATION
1q21.3
IMAGE
LEGEND
AF1q (1q21) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
ALIAS
AF1Q
FUSION GENES
DNA/RNA
Transcription
1.8 kb mRNA; coding sequence CDS 401... 673
Proteins
Description
90 amino acids; 9 kDa
Expression
detected in various tissues (small intestine, colon, thymus
mainly), but not in (normal) mature blood cells; expressed in all leukemic
cell lines tested
Function
unknown
Homology
no known homology
Implicated in
Entity name
Disease
AML
Prognosis
yet unknown
Hybrid gene
breakpoints: between exons 6 and 7 in MLL and within the 5
untranslated region in AF1q
Fusion protein
N-term -- AT hook and DNA methyltransferase from MLL fused to the
entire AF1q on the der(11); the reciprocal on der(1) is out of frame
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7542910 | 1995 | Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. | Bernard OA et al |
| 8558942 | 1996 | 11q23 rearrangements in acute leukemia. | Rubnitz JE et al |
| 7833468 | 1995 | A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells. | Tse W et al |
| 8977038 | 1996 | Chromosome abnormalities in leukaemia: the 11q23 paradigm. | Young BD et al |
Other Information
Locus ID:
NCBI: 10962
MIM: 604684
HGNC: 16997
Ensembl: ENSG00000213190
Variants:
dbSNP: 10962
ClinVar: 10962
TCGA: ENSG00000213190
COSMIC: MLLT11
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000213190 | ENST00000368921 | Q13015 |
| ENSG00000213190 | ENST00000368921 | Q6FGF7 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38075552 | 2023 | MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells. | 0 |
| 38203610 | 2023 | MLLT11 Regulates Endometrial Stroma Cell Adhesion, Proliferation and Survival in Ectopic Lesions of Women with Advanced Endometriosis. | 0 |
| 38075552 | 2023 | MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells. | 0 |
| 38203610 | 2023 | MLLT11 Regulates Endometrial Stroma Cell Adhesion, Proliferation and Survival in Ectopic Lesions of Women with Advanced Endometriosis. | 0 |
| 34828371 | 2021 | A Monoallelic Variant in REST Is Associated with Non-Syndromic Autosomal Dominant Hearing Impairment in a South African Family. | 4 |
| 34828371 | 2021 | A Monoallelic Variant in REST Is Associated with Non-Syndromic Autosomal Dominant Hearing Impairment in a South African Family. | 4 |
| 31273546 | 2020 | AF1q Expression Associates with CD44 and STAT3 and Impairs Overall Survival in Adenoid Cystic Carcinoma of the Head and Neck. | 3 |
| 32964980 | 2020 | LPAR5 stimulates the malignant progression of non-small-cell lung carcinoma by upregulating MLLT11. | 7 |
| 31273546 | 2020 | AF1q Expression Associates with CD44 and STAT3 and Impairs Overall Survival in Adenoid Cystic Carcinoma of the Head and Neck. | 3 |
| 32964980 | 2020 | LPAR5 stimulates the malignant progression of non-small-cell lung carcinoma by upregulating MLLT11. | 7 |
| 31671695 | 2019 | The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer. | 7 |
| 31671695 | 2019 | The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer. | 7 |
| 30154435 | 2018 | Novel AF1q/MLLT11 favorably affects imatinib resistance and cell survival in chronic myeloid leukemia. | 5 |
| 30154435 | 2018 | Novel AF1q/MLLT11 favorably affects imatinib resistance and cell survival in chronic myeloid leukemia. | 5 |
| 27510506 | 2017 | The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia. | 5 |
Citation
Olivier Bernard
MLLT11 (ALL1 fused gene from chromosome 1q)
Atlas Genet Cytogenet Oncol Haematol. 1998-04-01
Online version: http://atlasgeneticsoncology.org/gene/12/case-report-explorer/gene-explorer/cookies-notice
